In this research, the silver nanoparticle (AgNP) was rapidly prepared by simple solution method within 1 hour at room temperature and 80 °C in the present and the absent poly ethylene glycol (PEG). The curcumin-silver nanoparticle was synthesized from silver nitrate as precursor and sodium bore hydrate as reduction in two conditions included water solvent and poly ethylene glycol in water solvent at room temperature as solution method and 80 °C as hydrothermal method. The samples were characterized by Fourier transforms infrared spectroscopy (FTIR) for determination of functional groups, x-ray diffraction (XRD) for investigation of crystalline structure, scanning electron microscopy (SEM) for definition of morphology and size, and thermogravimetric analysis (TGA) for measuring of loading. The antibacterial activity of the samples was measured by agar diffusion method against Escherichia coli (E. coli) that affected silver nanoparticle and curcumin. Based on the results, curcumin-AgNP nanoparticle was developed potential for antibacterial application. Manuscript profile

In this research, the silver nanoparticle (AgNP) was rapidly prepared by simple solution method within 1 hour at 25 and 80 °C in the present and the absent polyethylene glycol (PEG). The curcumin-silver nanoparticle was synthesized from silver nitrate as precursor and sodium bore hydrate as a reduction in two conditions included water solvent and polyethylene glycol in water solvent at 25 °C as solution method and 80 °C as thermal method. The agar diffusion method was used for determination of the antibacterial activity of the samples against Escherichia coli (E. coli). The antibacterial properties against E.coli were observed because of the presence of AgNP. Based on the results, the curcumin loading and release was affected by temperature and PEG. The curcumin-AgNP nanoparticle can have a good potential for antibacterial activity and loading and release of the drug. Manuscript profile