The Lamiacae family is one of the largest herbal familiesWhich has about 200 genera and two to five thousand species. This family contains important medicinal herbs. Thymus migricus and Origanum vulgar are two important species of this family that have anti-oxidant and anti-radical properties. In this study, total phenol content and anti-CAD activity of absolute ethanol extract, absolute methanol, ethanol 50%, and methanol 50% were studied in two species of Origanum.vulgar and Thymus.migricus in West Azarbaijan province.The most phenolic, flavonoid, regenerative, inhibitory power of fat peroxidation, radical accumulation power and total antioxidation were found in methanolic extract of Origanum.vulgar species.The results showed that the antioxidant activity, the free radical control, and the fracture velocity of the chain, in addition to the total phenol, depend on the nature of the compounds.Generally, Origanum.vulgar can be used as a natural antioxidant in the food and pharmaceutical industry.aaaa.aa.aaaa aa aa aa aa aa aa . Manuscript profile