Obesity is at epidemic proportions in the world. Evidence supports increased physical activity and exercise are efficacious in controlling obesity, in part due to altering select adipocytokine levels. The present study aimed to compare the effect of 12 weeks of three resistance training methods (traditional, circular and interval) on the levels of the adipocytokine asprosin and body composition in sedentary men with obesity. Forty-four sedentary men with obesity, who were randomly divided into the 4 equal groups: traditional, circular, and interval resistance training as well as a control group. Results showed that there was a significant interaction between the type of training used and time on asprosin levels (F (1,40)= 13353.03, P= 0.001, ES= 0.99). All types of resistance training decreased asprosin levels and improved body composition parameters in comparison to the control group (F (3, 40) = 34.60, P = 0.001, ES= 0.77). Interval resistance training had the greatest effect on reducing asprosin levels and improving body composition related outcomes (body mass: P=0.001, ES=0.633, body mass index: P=0.001, ES=0.632, percent body fat: P=0.001, ES=0.647, waist to hip ratio: P=0.001, ES=0.786). The results of the present study support the benefits of resistance training as a non-pharmacological approach in reducing asprosin levels and improving body composition in individuals with obesity. Manuscript profile

Infection with the COVID-19 virus has a wide range of adverse effects on the metabolic and endocrine systems, and in fact, one of the main ways of influencing this new virus has been through these systems. This is why people with chronic underlying diseases such as obesity, diabetes, metabolic syndrome, and hypertension show more severe symptoms and higher mortality rates. On the other hand, exercise can reduce the symptoms resulting from disease and reduce its lasting effects by improving metabolic health and modulating hormonal mechanisms. Due to the new and unknown nature of COVID-19, clinical trials and experimental studies have not been performed to investigate the effect of exercise on mortality or severity and persistence of symptoms in patients with COVID-19, but exercise with modifications can improve insulin resistance, reduce the amount of mass, improve fat and anti-inflammatory properties, and increase the expression of ACE2 receptors, intracellular metabolism and other pathways that all can play a positive role in combating the virus. Due to the unknown aspects of the mechanism of COVID-19 and exercise, more studies need to be done on the dose-response relationship of exercise before and after the infection in different age groups and specific groups. Manuscript profile