Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis. Manuscript profile

SBA-15 was prepared and then functionalized with N-methyl-N’-propyltrimethoxysilyl imidazolium chloride as ionic liquid moiety. The ionic liquid functionalized SBA-15 (SBA-IL) was characterized by different analytical techniques including FT-IR, N2 adsorption-desorption, TGA and SEM image. According to the obtained results it was found that the organic groups were grafted onto the pores of SBA-15 because its pore size and BET surface dropped after modification step. Then, it was used as an efficient nanoreactor in the synthesis of biologically active henna based benzochromene derivatives under solvent‐free conditions. Consequently, the catalyst acted efficiently under solvent free system and gave the products in high yields and short reaction times. Some of the obtained products exhibited antibacterial activities as well as tetracycline. Manuscript profile

A Simple and efficient method for synthesis of tetrahydropyrimido[4,5-b]quinoline derivatives via three component reaction of aromatic aldehydes, dimedone and 6-amino uracil derivatives using a catalytic amount of sulfonic acid functionalized nanoporous silica (SBA-15-Pr-SO3H) is described. The advantages of this method are easy and clean work-up, high yield, mild reaction condition, reusable catalyst and environmentally benign solvents. Antibacterial and antifungal activities of synthesized compounds were measured against gram positive, gram negative bacteriaand fungus. Only compounds 4c and 4g showed activity against Staphylococcus aureus. Manuscript profile

Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free condition. This new protocol for Biginelli reaction has important advantages such as green synthesis, short reaction time, easy isolation and high yields of products and reusability of the catalyst. SBA-Pr-SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst which could be easily handled and removed from the reaction mixture by simple filtration and can be recovered and reused for several times without any loss of activity. Manuscript profile

The acidic agent (SO3H) was stabilized on the silica coated Fe3O4 magnetic nanoparticles to produce Fe3O4@SiO2@Pr-SO3H, as a heterogeneous acidic catalyst, was designed, and then fully studied and characterized by FT-IR, XRD, TGA, DTA, TEM, and SEM analysis. Subsequently, the catalytic activity of Fe3O4@SiO2@PrSO3H was investigated by the one-pot four- component condensation reaction between 1,3-indandione, aromatic aldehydes, acetophenone or propiophenone and ammonium acetate under the solvent-free condition at 80 ℃. The main advantages of this magnetic and heterogeneous acidic catalyst are high product yields, being environmentally benign, short reaction times, and easily separated from the reaction mixture using an external magnet. Manuscript profile

In this study, Bis (2-hydroxyethyl)amine functionalized mesoporous SBA-15 was synthesized for utilization in amoxicillin drug-delivery. Amoxicillin could absorb on the prepared functionalized SBA-15. A solution of amoxicillin in a suitable solvent was used for this purpose. Amoxicillin molecules release from the matrix into a simulated body fluid (SBF) solution, and phosphate buffers were studied. UV-Vis spectrophotometric method was chosen for amoxicillin determination. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), nitrogen adsorption–desorption, and powder X-ray diffraction (XRD) technique were applied for characterization of the synthesized materials. The best loading of amoxicillin was done at pH 8.5 after stirring for 30 minutes. The results showed that, at lower pH, releasing of the drug was done faster than it at higher pH. Also, the average release rate of amoxicillin in the body fluid samples that were simulated was about 7 µg h-1. A highly slow release pattern was observed. The proposed material can be used for enhancing the medical impact of amoxicillin and carrying amoxicillin. Manuscript profile