Global population growth is the main driver of an unsustainable food system with the increased problem of Food Loss and Waste (FLW) as the most severe consequence. Based on data from Indonesia Statistics (BPS), in 2024, Indonesia's population reached more than 281 people. The pile of FLW in Indonesia reaches 48 million tons/year and efforts to overcome it are still challenging. This research aims to determine the drivers, pressures, impacts, and responses of FLW globally as a sustainable intervention model for FLW mitigation in Indonesia. Economic, political, cultural, and socio-demographic drivers of FLW are explained, highlighting global variations. The method used in this research is a systematic literature review of 54 FLW studies at the global level. Pareto is used to analyze the components of findings that need to be prioritized based on 80 percent cumulative contribution. The literature is in English, taken from reputable journals on the Scopus database within the last 5 years, distributed from 2019-2024. The research results reveal 12 drivers, 12 pressures, 10 impacts, and 11 global FLW responses based on sustainable aspects, namely environmental, social, and economic. Moreover, it was found that all 18 FLW drivers in Indonesia were recorded in the global FLW drivers and pressures findings in this study. So, the response findings in this study can be considered for adoption in Indonesia. This approach may be very useful for scientists, local governments, and policymakers to identify global variations and focus on their future implications. Manuscript profile