This paper proposes a sub-optimal Extended State-Dependent Differential Riccati Equation (ESDDRE) controller for nonlinear Reaction-Advection-Diffusion (R-A-D) Partial Differential Equation (PDE) systems with multiple delays. A State-Dependent Riccati Equation (SDRE) is a nonlinear version of Linear Quadratic Regulator (LQR) in optimal control and it is used to analyze nonlinear optimal control problems. Instead of the linearization or the Jacobin procedure, the ESDDRE technique applies a State-Dependent Coefficients (SDC) for parameterization to construct an Extended Pseudo-Linearization (EPL) representation. All of the multiple delays sections in this presentation can be located in the system matrices and input vectors. The control effort of ESDDRE method is derived based on the Hamiltonian equation and also cost function according to the PDE systems. In addition, the L_2 stability is guaranteed by Poincaré inequality and as well as Lyapunov function regarded on the ESDDRE control strategy for the closed-loop system. The simulation results for the nonlinear R-A-D partial differential equation with one and two constant delays indicate that the proposed ESDDRE controller technique is efficient. Manuscript profile