The effect of endurance and resistance training on the expression of myostatin and follistatin genes in the biceps muscle of aged male rats.
Subject Areas : Effect of Physical Activity on Diseases
Mahtab Moazzami
1
,
Nasrin Nobahari
2
1 - Sports Physiology, Faculty of Physical Education, Ferdowsi University, Mashhad, Iran
2 - Department of Physical Education and Sports Sciences, Bojnoord Islamic Azad University, Bojnoord, Iran
Keywords: aging, sarcopenia, myokines, endurance training, strength trainin,
Abstract :
Background and purpose: Aging is a natural process in human life. Sarcopenia is a gradual decrease in muscle mass and function that occurs with age. Materials and methods: In the present study, 30 male Wistar rats at the age of 18 weeks were randomly divided into three groups, endurance training, resistance training and control (each group contains 10 rats). became Then, endurance and strength training groups participated in their own training for 8 weeks and 5 sessions per week. Results: The results of analysis of variance showed that there is a significant difference between the values of myostatin gene and follistatin gene in endurance, resistance and control groups. Also, the results of Tukey's post hoc test showed that endurance and resistance exercises had a significant effect on reducing myostatin gene expression. Also, the results of this test showed the increase of folstatin gene in both endurance and resistance groups compared to the control group. Conclusion: The results of statistical tests showed a significant decrease in the expression of the myostatin gene and a significant increase in the expression of the follistatin gene in the endurance and strength training groups compared to the control group. Finally, the findings of this study showed that strength and endurance training can change the expression of genes involved in hypertrophy of the quadriceps muscle of aged male rats. And it seems that these types of exercises can be useful to reduce the complications of sarcopenia caused by aging.
