A review of the effects of exercise on improving memory, learning and reducing the risk factors for Alzheimer's disease

Subject Areas : Open Access

Omidreza Salehi ¹ , Mahboobeh Yousefian ² , Masoud Kiani ³ , Zahra Mosalanejad ⁴

1 - Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran
2 - Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Khorasgan Branch, Islamic Azad University, Isfahan, Iran
3 - Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, kermanshah Branch, Islamic Azad University, kermanshah , Iran
4 - Department of Physical Education, Zand Higher Education Institute, Shiraz, Shiraz, Iran.

Received: 2021-11-28 Accepted : 2021-12-10 Published : 2022-05-22

Keywords: exercise training, Learning, Memory, Alzheimer's Disease, Neurotrophins,

Abstract :

AbestractIntroduction: Alzheimer's disease is the most common age-related disease. ) is. Neurotrophic factors are widely expressed in the brain, but are significantly reduced in the brains of Alzheimer's patients. Therefore, the aim of this study was to evaluate exercise in the function of neurotrophins, psychological disorders and reduction of risk factors for Alzheimer's disease.Methods: For this purpose, in all databases, especially Web of Science, Pubmed, Google scholar, SID.IR, Mageiran, with the keywords Exercise training, Memory, Alzhimer risk factors, etc., a search was performed without year limit. The articles were then categorized based on exercise activity on memory and learning as well as risk factors for Alzheimer's disease.Results: Among the studies, studies on the effect of exercise on risk factors, neurotrophins, memory and learning were reviewed. Their results showed that exercise depending on the type and intensity with the improvement of neurotrophins, increasing the total antioxidant capacity leads to improved cognitive function in Alzheimer's disease.Conclusion: It seems that long-term and regular exercise has a beneficial effect on neurotrophin mechanisms, improving antioxidant capacity, memory and learning in Alzheimer's disease; However, these effects depend on the intensity and length of the training period, and the mechanism of exercise on oxidative stress in brain tissue is not yet well understood.