The effects of Oleoreupien on prostate and seminal vesicle tissues in streptozotocin induced diabetic rats
Subject Areas :
Veterinary Clinical Pathology
Farzin Javid
1
,
Esmaeil Safavi
2
,
Esmaeil Safavi
3
,
Yoosef Doustar
4
1 - graduated of veterinary medicine,facultyof veterinary medicine,islamic azad university ofTabriz,Tabriz,Iran
2 - Assistant Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Tabriz
Branch, Islamic Azad University, Tabriz, Iran.
3 - Assistant Professor, Department of Basic Sciences, Biotechnology research center, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
4 - Associate Professor, Department of Pathobiology, Tabriz Branch, Islamic Azad
University, Tabriz, Iran.
Received: 2017-08-08
Accepted : 2019-03-10
Published : 2019-04-21
Keywords:
Rat,
Diabetes,
Prostate,
Oleoreupien,
Seminal vesicle,
Abstract :
Diabetes impairs the normal reproductive system function by disrupting spermatogenesis and decreasing sperm count, serum testosterone level and seminal fluid volume. This study aimed to investigate the effects of oleoreupien on tissue changes of prostate and seminal vesicles in diabetic rats. Thirty male Wistar rats were randomly divided into 3 groups (n=10) including control, diabetic and treatment groups. Rats in the treatment group received Oleoreupien (500mg/kg) for 28 days by oral gavage after induction of diabetes by streptozotocin. At the end of the experimental period, samples of prostate and seminal vesicle were obtained and then slides were prepared and stained by H&E method for histological study. Morphological findings indicated increased secretion of prostate and seminal vesicles, significant increase in diameter of secretory units and significant decrease of interstitial connective tissue in the treatment group compared with the diabetic group. Histomorphometric results also indicated that epithelium height of the prostate and seminal vesicles and diameter of the tubules of the prostate significantly increased in the treatment group compared with the diabetic group (p < /em>˂0.05). The study also revealed that gland weight to body weight in the treatment group increased significantly compared with that of the diabetic group (p < /em>˂0.05). According to current findings, oral administration of Oleoreupien prevented diabetic induced tissue changes in prostate and seminal vesicle in rats.
References:
Abdolahnejad, A., Gol, A., Dabiri, S. and Javadi, A. (2011). Preventive and protective effects of garlic juice on histologic alternation in the prostate of Streptozotocin induced diabetic rats. Iranian Journal of Biology, 24(6): 904-914. [In Persian]
Ahmadvand, H., Noori, A., Dehnoo, M., Bagheri, S. and. Cheraghi, R. (2014). Hypoglycemic,hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced type 1 diabetic rats. Asian Pacific Journal of Tropical Disease, 4(2): 421-42.
Alirezaei, M., Kheradmand, A., Heydari, R.,Tanideh, N. and Neamati, S. (2012). Oleuropein protects against ethanol-induced oxidative stress and modulates sperm quality in the rat testis. Mediterranean Journal of Nutrition and Metabolism, 5(3): 205-211.
Andrikopoulos, N., Kaliora, A., Assimopolou, A. and Papaqeorqiou, V. (2002). Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. Journal of Medicinal Food, 5(1): 1-7.
Acquaviva, R., Digiacomo, C., Sorrenti, V.,Galvano, F. and Santangelo, R. (2012). Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology, 41(1): 31-38.
Baynes, J. and Thorpe, S. (1999). Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes, 48(1): 19-26.
Bendini, A., Cerretani, L., Carrasco, A., Gomez, A. and Sequara, A. (2007). Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. Molecules, 12(8): 167-171.
Carvalho, C., Camargo, A., Cagnon, V. and Padovani, C. (2006). Effects of experimental diabetes on the structure and ultrastructure of the coagulating gland of C57BL/6J and NOD mice. The Anatomical Record, 38(1): 142-151.
Cheng, J., Hsieh-Chen, S. and Tasi, C. (1989). L-ascorbic acid produces hypoglycemia and hyperinsulinemia in anaesthetized rats. Journal of Pharmacy and Pharmacology, 413(2): 45-53.
El-Kholy, T., AL-abbadi, H., Qahwaji, D. and AL-gamdi, A. (2015). Ameliorating effect of olive oil on fertility of male rats fed on genetically modified soya bean. Food and Nutrition Research, 59(1): 267-280.
Hamdi, H. and Castellon, R. (2005). Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochemical and Biophysical Research Communications, 334(3): 769-778.
Jemai, H., El feki, A. and Sayadi, S. (2009). Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. Journal of Agricultural and Food Chemistry, 57(19): 8798-8804.
Keys, A. (1995). Mediterranean diet and public health: personal reflections. The American Journal of Clinical Nutrition, 61(6): 1321-1323.
Lavignera, S., Acondorelli, R., Vicari, E., Agata, R. and Ecalogero, A. (2011). Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control. Asian Journal of Andrology, 13(6): 872-883.
Oi-Kano, Y., Kavada, T., Watanabe, T., Koyama, F. and Senbongi, R. (2010). Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet. Journal of Nutritional Biochemistry, 24(5): 887-893.
Oi-Kano, Y., Kavada, T., Watanabe, T., Koyama, F. and Senbongi, R. (2008). Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. Journal of Nutritional Science and Vitaminology, 54(5): 363-370.
Omar, S. (2010). Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica, 78(2 :( 133-154.
Stretch, A. and Hayball, P. (2000). Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine. The Journal of Nutrition, 130(12): 2996-3002.
Soler, R., Espín, J. and Wichers, H. (2000). Oleuropein and related compounds. Journal of the Science of Food and Agriculture, 80(7): 1013-1023.
Sudha, S., Sankar, B., Valli, G. and Govindarajvulu, P. (1990). Streptozotocin-diabetes impairs prolactin binding to Leydig cells in prepubertal and pubertal rats. Hormone and Metabolic Research, 31(11): 583-586.
Tesone, M., Oliviera-Filho, R., Biella de Souza, V., Calvo J., Baranao, J. and Foglia, V. (1980). Androgen receptors in the diabetic rat. Diabetologia, 18(3): 385-390.
Zahkok, S., Nehad, A., Amel, F. and Esraa, M. (2016). Studies on fertility of diabetic male rats treated with olive leaves extract. Journal of Biomedical and Pharmaceutical Research, 5(3): 18-27.
_||_
Abdolahnejad, A., Gol, A., Dabiri, S. and Javadi, A. (2011). Preventive and protective effects of garlic juice on histologic alternation in the prostate of Streptozotocin induced diabetic rats. Iranian Journal of Biology, 24(6): 904-914. [In Persian]
Ahmadvand, H., Noori, A., Dehnoo, M., Bagheri, S. and. Cheraghi, R. (2014). Hypoglycemic,hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced type 1 diabetic rats. Asian Pacific Journal of Tropical Disease, 4(2): 421-42.
Alirezaei, M., Kheradmand, A., Heydari, R.,Tanideh, N. and Neamati, S. (2012). Oleuropein protects against ethanol-induced oxidative stress and modulates sperm quality in the rat testis. Mediterranean Journal of Nutrition and Metabolism, 5(3): 205-211.
Andrikopoulos, N., Kaliora, A., Assimopolou, A. and Papaqeorqiou, V. (2002). Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. Journal of Medicinal Food, 5(1): 1-7.
Acquaviva, R., Digiacomo, C., Sorrenti, V.,Galvano, F. and Santangelo, R. (2012). Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology, 41(1): 31-38.
Baynes, J. and Thorpe, S. (1999). Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes, 48(1): 19-26.
Bendini, A., Cerretani, L., Carrasco, A., Gomez, A. and Sequara, A. (2007). Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. Molecules, 12(8): 167-171.
Carvalho, C., Camargo, A., Cagnon, V. and Padovani, C. (2006). Effects of experimental diabetes on the structure and ultrastructure of the coagulating gland of C57BL/6J and NOD mice. The Anatomical Record, 38(1): 142-151.
Cheng, J., Hsieh-Chen, S. and Tasi, C. (1989). L-ascorbic acid produces hypoglycemia and hyperinsulinemia in anaesthetized rats. Journal of Pharmacy and Pharmacology, 413(2): 45-53.
El-Kholy, T., AL-abbadi, H., Qahwaji, D. and AL-gamdi, A. (2015). Ameliorating effect of olive oil on fertility of male rats fed on genetically modified soya bean. Food and Nutrition Research, 59(1): 267-280.
Hamdi, H. and Castellon, R. (2005). Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochemical and Biophysical Research Communications, 334(3): 769-778.
Jemai, H., El feki, A. and Sayadi, S. (2009). Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. Journal of Agricultural and Food Chemistry, 57(19): 8798-8804.
Keys, A. (1995). Mediterranean diet and public health: personal reflections. The American Journal of Clinical Nutrition, 61(6): 1321-1323.
Lavignera, S., Acondorelli, R., Vicari, E., Agata, R. and Ecalogero, A. (2011). Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control. Asian Journal of Andrology, 13(6): 872-883.
Oi-Kano, Y., Kavada, T., Watanabe, T., Koyama, F. and Senbongi, R. (2010). Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet. Journal of Nutritional Biochemistry, 24(5): 887-893.
Oi-Kano, Y., Kavada, T., Watanabe, T., Koyama, F. and Senbongi, R. (2008). Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. Journal of Nutritional Science and Vitaminology, 54(5): 363-370.
Omar, S. (2010). Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica, 78(2 :( 133-154.
Stretch, A. and Hayball, P. (2000). Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine. The Journal of Nutrition, 130(12): 2996-3002.
Soler, R., Espín, J. and Wichers, H. (2000). Oleuropein and related compounds. Journal of the Science of Food and Agriculture, 80(7): 1013-1023.
Sudha, S., Sankar, B., Valli, G. and Govindarajvulu, P. (1990). Streptozotocin-diabetes impairs prolactin binding to Leydig cells in prepubertal and pubertal rats. Hormone and Metabolic Research, 31(11): 583-586.
Tesone, M., Oliviera-Filho, R., Biella de Souza, V., Calvo J., Baranao, J. and Foglia, V. (1980). Androgen receptors in the diabetic rat. Diabetologia, 18(3): 385-390.
Zahkok, S., Nehad, A., Amel, F. and Esraa, M. (2016). Studies on fertility of diabetic male rats treated with olive leaves extract. Journal of Biomedical and Pharmaceutical Research, 5(3): 18-27.
