Phytochemical investigation of the extract of Astragalus tragacantha collected from the vegetative areas of Meshkin Shahr and its antimicrobial effects on some common oral and dental bacteria

Subject Areas : The Application of Chemistry in Environment

Hojjat Eghbal ¹ , Mehdi Ahmadi Sabegh ²

1 - Department of Phytochemistry, Basic Sciences Research Center, Tabriz University, Iran.
2 - Department of Chemistry, Faculty of Basic Sciences, Islamic Azad University, Ahar Branch.

Received: 2022-08-22 Accepted : 2022-09-14 Published : 2020-09-22

Keywords: Antimicrobial, Phytochemical, phenolic compounds, Astragalus tragacantha,

Abstract :

Introduction and purpose: Recently, due to the increasing resistance of microorganisms to common antibiotics, the use of phenolic and antimicrobial compounds in medicinal plants has received special attention.Materials and methods: Gon extract was extracted by maceration method and their phenolic compounds were identified by HPLC, the antimicrobial effect of the extract was investigated in concentrations (25, 50 and 100 µg/ml). These bacteria included common microbes and fungi, including Streptococcus mutans, Streptococcus sanguinis, Streptococcus salivaris, Streptococcus subrinus, Escherichia coli, Icnella cordens, Pseudomonas aeruginosa and Klebsiella pneumoniae. Disc diffusion and MIC methods were used to investigate the antimicrobial activity of the extracts.Findings: In the investigation of the effect of the desired extract on bacteria, it was found that the medicinal plant Gon has the least inhibitory effect against Streptococcus sanguinis bacteria and the most inhibitory effect on Candida glabrata fungus. The results of the MIC test also confirm these effectsConclusion: According to the phytochemical results obtained from the extract of this research, it can be stated that the studied medicinal plant has antibacterial phenolic compounds. Therefore, the results of the research showed that the extract of the medicinal plant Goon has a suitable anti-microbial effect against the bacteria causing oral and dental infections, and it was expressed as an alternative to the standard drugs chlorhexidine and nystatin.