A review of the role of perilipin in fatty liver with an exercise approach
Subject Areas : Physical Activity and Health
Nafiseh Sadeghi
1
,
Saleh Rahmati
2
1 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
Keywords: energy consumption, Triglycerides, Fat, lipolysis, Exercise,
Abstract :
The benefits of physical activity in individuals with fatty liver disease are widely acknowledged. Fatty liver disease occurs when an excessive amount of fat builds up in liver cells, resulting in inflammation and potential long-term liver damage. Perilipin, a protein present in fat cells, plays a crucial role in regulating lipid metabolism, including the storage and breakdown of triglycerides. It has been scientifically proven that regular physical exercise has a positive impact on the connection between perilipin and fatty liver, creating a healthier environment for the liver. Physical activity enhances the expression and activity of perilipin, aiding in the release of stored triglycerides from liver cells. This allows for their metabolism and utilization as fuel during physical activity. Furthermore, physical activity stimulates lipolysis, the process of breaking down stored fat into free fatty acids, which can then be utilized for energy production. By increasing the activity of perilipin, this process is facilitated, preventing excessive accumulation of triglycerides in liver cells. Regular physical activity also increases energy expenditure and assists with weight management, as overweight and obesity are significant risk factors for the development and progression of fatty liver disease. The present study aims to investigate the relationships between perilipin, fatty liver, and the positive effects of physical activity on these interactions.
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