Etiology of Trichotillomania in Monozygotic and Dizygotic Twins (An integrated Genetic, Environmental and Behavioral Model)
Subject Areas : Psychologykazem khorramdel 1 , Usha Brahmand 2 , Abbas Abolghasemi 3 , soode dashtiane 4 , shiva zare 5
1 - Assistant Professor, Department of psychology. Fatemiyeh Shiraz, Institute of Higher Education. Shiraz.
2 - Associate Professor, Department of psychology, CUNY Queens College, Washington, USA.
3 - Professor, Department of psychology, University of Guilan, Rasht, Iran.
4 - Psychology. Department of psychology. Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
5 - Psychology, Department of psychology, Fatemiyeh Shiraz, Institute of Higher Education, Shiraz.
Keywords: Monozygotic Twins, Dizygotic Twins, Obsessive Compulsive Disorders, Hair-Pulling Disorder, Environmental and Behavioral.,
Abstract :
Trichotillomania is a clinical psychiatric manifestation involving significant hair loss in association with recurrent hair-pulling behavior, the etiology of which is still unknown. The aim of this study was to investigate the genetic and environmental and behavioral contribution to trichotillomania (hair-pulling disorder) and to relate the findings to contemporary theories about the etiology. This was a descriptive correlational and twins study design. 672 twins (MZ=474; DZ=202) were selected from Iranian twins associations in 2018. The Massachusetts General Hospital Hair-pulling Scale(1995) and the Self-Report of Zygosity were used as research instrument. Twin modeling methods were employed to decompose the variance in the liability trichotillomania (hair-pulling disorder) into additive genetic and shared and non-shared environmental factors. The data was analyzed by SPSS, STATA and M-plus. Univariate model-fitting analyses showed that genetic factors accounted for approximately 64% of the variance in TTM. The best extracted model for TTM was the DE model. The correlation coefficient results indicated that the correlation rate was 0/61 and 0/31 in MZ and DZ group respectively. It can be concluded that TTM phenotype is the results of a polygenetic. There is no intermediate despite of the dominance effect and it results from a gene-gene interaction or a dominant gene.
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