The effect of diabetes on reserpine-induced catalepsy in rats model of Parkinson's disease
Subject Areas : zoology
1 - دانشجو/دانشگاه ازاد اسلامی واحد قم
2 - هیئت علمی دانشگاه أزاد اسلامی واحد قم
Keywords: Diabetes, Parkinson', s disease, reserpine, bar-test, Rat,
Abstract :
Aim and Background: Parkinson's disease is a neurodegenerative disease in the central nervous system, characterized by dopaminergic neuronal loss in the nigrostriatal system with clinical symptoms such as resting tremor, rigidity, akinesia, and disturbances of postural reflex.The aim of this study was to investigate the effect of diabetes on reserpine-induced catalepsy in male rats model of Parkinson's diseaseMaterial and Methods: In this study, 24 Wistar rats were divided in 4 groups (control, diabetes, Parkinson's disease, Parkinson's disease + diabetes).Each of animals in the diabetic groups was given a single injection of streptozotocin (60 mg/kg, i.p). Parkinson's disease was induced by administration of Reserpine (1 mg/kg, i.p)The bar- test was used to measure cataleptic symptoms. Catalepsy was evaluated by placing both forepaws of the rat on a horizontal bar.SPSS software was used for analyzing data by using of analysis of variance that it was performed at a significance level of p<0.05.Results: catalepsy was significantly higher in the group of diabetes + Parkinson's disease.Conclusion: Diabetes can be effective on reserpine-induced catalepsy in male rats model of Parkinson's disease.
