The Effect of 8 Weeks High Intensity Interval Training on GLP-1 Expression in Pancreatic Tissue and Beta Cell Function in Obese Rats with Type 2 Diabetes
Subject Areas : Physical Activity and Healthداود خورشیدی 1 , Mehrdad Noorikhah 2
1 -
2 - Department of Physical Education and Sport Sciences, Sav.C., Islamic Azad University, Saveh, Iran
Keywords: Interval Training, Type 2 Diabetes, Beta Cell Function, Incretin ,
Abstract :
Aim: Glucagon-like peptide-1 (GLP-1) is an incretin hormone that plays a role in the pathogenesis and treatment of type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on GLP-1 expression in pancreatic tissue in T2DM rats.
Method: In this experimental study, fourteen males Wistar rats with T2DM induced by streptozotocin-nicotinamide injection were randomly divided into exercise (n=7) and control (n=7). The exercise group performed the HIIT protocol on a treadmill for 8 weeks and 5 days per week. GLP1 expression in pancreatic tissue, blood glucose level, insulin and beta cell function were measured 48 hours after the last training session. Data were analyzed by independent T test at P< 0.05.
Results: After the exercise intervention, GLP-1 expression in pancreatic tissue, serum insulin and beta cell function were significantly higher in the exercise group compared to the control group (P˂0.05). Blood glucose levels were significantly lower in the exercise group than in the control group (P˂0.05).
Conclusion: Based on these findings, it appears that the improvement in blood glucose and beta cell function in response to HIIT are partially dependent on increased GLP-1 expression in the pancreatic tissue.
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