The Impact of Resveratrol Supplementation on Oxidative, Inflammatory, and Cellular Damage Markers Following of High-Intensity Resistance Exercise in Non-Athletic Women
Subject Areas : Sports Science and Healthy
somayeh fatahi
1
,
Akram Jafari
2
1 - Department of Physical Education and Sports Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2 - Assistant professor
Keywords: inflammation, resistance exercise, oxidative stress, resveratrol,
Abstract :
A diet high in polyphenols can improve the antioxidant status of the body and reduce the oxidative damage caused by exercise and the release of pro-inflammatory cytokines so the aim of this study was to investigate the effect of resveratrol supplementation on certain oxidative, inflammatory, and cellular damage markers resulting from high-intensity resistance exercise in non-athletic women. 24 healthy non-athletic women (body mass index 20-25 kg/m2, age 20-30 years) voluntarily participated in the present study. These people were randomly divided into two groups: placebo and resveratrol supplement (12 people in each group). The subjects of two groups took a supplement or a placebo for one week (supplement group 400 mg resveratrol daily and placebo group the same amount daily in the form of essential oil capsules) and then participated in a resistance activity session with 85% of a maximum repetition. In 3 stages (before Yari supplementation, before resistance training and immediately after resistance training) blood was taken and the levels of malondialdehyde, total antioxidant capacity, creatine kinase, c-reactive protein and uric acid were analyzed. The results of the present study showed that seven days of resveratrol consumption in the supplement group led to an increase in total antioxidant capacity and a decrease in malondialdehyde levels compared to pre-supplementation (p ≤ 0.01). Additionally, resveratrol supplementation was able to prevent a significant increase in creatine kinase and a significant decrease in total antioxidant capacity after the resistance exercise (p < 0.05). The findings of the present research showed that resveratrol supplementation has protective effects against oxidative damage caused by intense resistance exercise in young women by reducing malondialdehyde and creatine kinase and increasing total antioxidant capacity. These beneficial effects are probably attributed to the inherent antioxidant activities of resveratrol. In the present study, limitations such as the small number of subjects and the use of a specific age and gender range reduce the ability to generalize the results. On the other hand, the inability to precisely control the subjects' diet is another limitation of this study. It is suggested that future studies use larger groups or groups of different ages to examine the effects of resveratrol supplementation in other individuals. Another limitation of the study was the inability to examine other oxidative stress factors, and it is suggested that future studies examine the effects of this supplement on other physiological variables to gain a deeper and more complete understanding of this supplement on exercise-induced oxidative stress factors.
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