The effect of aerobic exercise on mitochondrial mitophagy

Subject Areas : microbiology

faranak amini ¹ , mohammadali Azarbayjani ² , shahin riyahi ³ , Lida Moradi ⁴

1 -
2 - 2- گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی
3 - Department of exercise physiology, East, Tehran Branch, Islamic Azad University, Tehran.Iran
4 - 1- Department of exercise physiology, North Tehran Branch, Islamic Azad University, Tehran.Iran

Received: 2024-06-08 Accepted : 2024-11-16 Published : 2024-11-16

Keywords: Mitophagy, aerobic exercise, oxidative stress, inflammation, apoptosis,

Abstract :

Mitochondria is one of the dynamic organelles in the cell, the dysfunction of which weakens the function of the cell and ultimately causes cell death. Mitophagy is the selective autophagy of damaged mitochondria, which improves cell biological functions by removing dysfunctional mitochondria. The PINK1-Parkin signaling pathway is one of the most important mitophagy regulation pathways. The PINK1-Parkin signaling pathway is one of the most important mitophagy regulation pathways. Disruption of mitophagy is the main cause of many metabolic, neurodegenerative diseases, cancers and aging. The evidence obtained from human and animal studies shows that aerobic exercise develops mitochondrial mitophagy by regulating and activating signaling pathways and maintains health at the cell level, thereby reducing the incidence of diseases. Although the exact molecular mechanism of the effect of aerobic exercise on the development of mitochondrial mitophagy is not known, the results of several studies show a reduction in oxidative stress, inflammation, apoptosis, and an increase in anti-inflammatory myokines along with regular aerobic exercise by activating mitophagic signaling pathways, especially the PINK1 signaling pathway. -Parkin regulates mitophagy in various tissues and in the conditions of old age, obesity, inactivity and metabolic disorders and prevents the development of many diseases. The regulatory role of aerobic exercises on mitophagy emphasizes the effectiveness of these exercises on tissue protection and health development.

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