The effect of colchicin on pain and function of patients with primary knee osteoarthritis

Subject Areas : علوم پزشکی

Mohammad Mahdi Nejad Kashani ¹ , Atefeh Gilan Varnosfaderani ²

1 - استادیار، دانشکده پزشکی، دانشگاه آزاد اسلامی مشهد، مشهد، ایران.
2 - دانشجوی رشته پزشکی، دانشکده پزشکی، دانشگاه ازاد اسلامی مشهد، مشهد، ایران.

Received: 2017-06-05 Accepted : 2017-06-05 Published : 2013-11-22

Keywords: Colchicine, pain, Osteoarthritis, Knee function,

Abstract :

Background and objective:As crystals may contribute to inflammation in osteoarthritis (OA), it is hypothesized that colchicines may affect on symptoms of patients with primary knee OA. Our objective was to evaluate the symptomatic benefits of colchicines on pain and function of patients with primary knee OA. Methods:  There were 180 patients in two groups (90 in colchicines and 90 in control group), enrolled in this study. Those patients with chronic hepatitis, gastrointestinal or hematologic diseases were excluded. At the first, age, sex, pain and knee function were registered. Using visual analogue scale (VAS) for pain and koos ps criteria for knee function. The Case group received 0.5mg colchicines twice a day and both groups received diclophenac in order to use if they had pain. Pain and knee function was measured again after 3 months. For analyzes SPSS v.20 and Statistica v.10 has been used. Results:  Mean age of patients was 60±5.4 years (50-70), and 53.9% were women. There was no significant difference between two groups considering percentage of pain relief (P>0.05). Also there was no significant correlation between pain relief percentage and age, sex, or affected side. But function of knee was significantly higher in case group after 3months (P=0.019).  The patients function recovery percentage was statically significant in case group (P=0.001). The relation of function with age (less than 60) P=0.001, sex (women) P=0.004 and affected side (Bilateral) P=0.003 was significant. Conclusion:More studies are needed in order to routine usage of colchicines in osteoarthritis.  

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