The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes

Subject Areas : Journal of Animal Biology

Soosan Rostam Pur ¹ , Yadolah Edalat panah ² , Fariba Enayati parvar ³ , Reza Haghighi ⁴

1 - Department of Medical Biotechnology, Iran University of Medical Sciences, Tehran, Iran
2 - Cellular and Molecular Research Center, Yasouj University of Medical Sciences, Yasuj, Iran
3 - Cellular and Molecular Research Center, Yasouj University of Medical Sciences, Yasuj, Iran
4 - Veterinary, Karaj Branch, Islamic Azad University, Karaj, Iran

Received: 2018-10-26 Accepted : 2019-03-10 Published : 2019-05-22

Keywords: Stem cell transplantation, Amnion, Type-1 diabetic model, Diabetes treatment,

Abstract :

Diabetes mellitus can occur due to insulin deficiency or environmental tissues resistance to insulin with the reduction of insulin secretion. The present study aimed to investigate the therapeutic effect of amniotic mesenchymal stem cell transplantation in the treatment of type 1 diabetes.  This study was of experimental type and the animals were divided into four groups including the control or healthy, the diabetic control group, the group receiving cells with the medium, and the group receiving only supernatant soup. Glucose and blood insulin levels and animal weight were studied by ANOVA and t-test during the study. With the first stage of stem cell transplantation, a significant reduction was found in the animal blood glucose of both groups receiving cell and medium (p = 0.004) and the group receiving supernatant soup (p = 0.014) than the control group. Such results were not observed after the second stage. The insulin levels had no statistically significant difference. The present study indicated that the repeated transplantation of Amniotic Mesenchymal stem cells can decrease the blood glucose but increase the blood insulin level and the injection of supernatant soup alone be solely effective as much as the cell transplantation.

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