Investigating the Destructive Effects of the Energizing Drug Oxymetholone on the Liver Tissue of NMRI Female Mice

Subject Areas : Journal of Animal Biology

Naeimeh  Dehghani ¹ (Department of biology, Payame Noor University, Tehran, Iran)
Hamed  Danesh Pajooh ² (Department of biology, Payame Noor University, Tehran, Iran)

Received: 2023-09-08 Accepted : 2023-11-26 Published : 2024-06-01

Keywords: Energizing Drug, Oxymetholone, Steroid, Liver, Mice,

Abstract :

Oxymetholone is an oral active anabolic-androgenic steroid. This drug was obtained in 1959 by methylating the 17α carbon and saturating the 5α carbon of testosterone. This drug in low doses are used to treat diseases such as; Anemia, lack of growth in children, reducing the spread of the AIDS virus in the body and heart failure are used. Unfortunately; some athletes use this drug as an energy-boosting drug in high doses due to its anabolic properties and its effect on muscle growth. In this study, the effect of Oxymetholone in a dose much higher than the physiological limit of the body was investigated on the liver of NMRI female mice. For this purpose, 12 mg/kg/day of the drug was injected intraperitoneally to adult mice (45 days old) for ten days. The results obtained from intraperitoneal (IP) injection of oxymetholone on the number of Kupffer cells in the liver in adult rats (NMRI) show that the number of Kupffer cells increased, which is significant at P<0.001. Also, according to the histograms related to The number of liver hepatocyte cells, the diameter of liver hepatocyte cells and the number of double nuclei in the liver and the results obtained, it can be seen that there is no significant difference in the comparison between the sham, control and experimental groups at P<0.05. The results of the present study show that the consumption of oxymetholone steroids can cause harmful effects on the liver tissue of athletes.

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