Comparative Effects of Benzyl Ester and Propylene Glycol Administration on Quantitative Indices of Rat Seminiferous Tubules

Subject Areas : Journal of Animal Biology

Atarod Sadat  Mostafavinia ¹ (Department of Anatomical and Neurocognitive Sciences, Medical Sciences Branch, Islamic Azad University, Tehran, Iran )
Zahra Nadia  Sharifi ² (Department of Anatomical and Neurocognitive Sciences, Medical Sciences Branch, Islamic Azad University, Tehran, Iran )
Mahnaz  Nouri ³ (Department of Obstetrics and Gynecology, Shahrood Branch, Islamic Azad University, Shahrood, Iran )
Parsa  Nazari ⁴ (Department of Biology, Faculty of Science, Khorram Abad University, Lorestan, Iran )
Fatemeh  Mohammadi ⁵ (Department of Anatomical and Neurocognitive Sciences, Medical Sciences Branch, Islamic Azad University, Tehran, Iran )
Parmida  Seraj ⁶ (Department of Anatomical and Neurocognitive Sciences, Medical Sciences Branch, Islamic Azad University, Tehran, Iran )
Seyed Mohammad Hossein  Noori Mugahi ⁷ (Department of Anatomical and Neurocognitive Sciences, Medical Sciences Branch, Islamic Azad University, Tehran, Iran )

Received: 2023-08-05 Accepted : 2023-11-24 Published : 2024-03-05

Keywords: Benzyl Ester, Propylene glycol, Seminiferous tubules,

Abstract :

According to highlighted role of men in family planning, the use of reversible methods of contraception with no adverse effects on androgen-dependent metabolic reactions is very important. In order to achieve a conductor combination in the designing contraceptive drugs, in the study, the effect of two drugs: Propylene glycol and Benzyl Ester on histological parameters of seminiferous tubules was investigated. This study was conducted on the 33 rats Sprague-Dawley with weighing 250-300 gr and least 100 days. Then they were divided into a group containing 13 rats and two groups containing 10 rats and were Received respectively 15 mg/kg of Propylene glycol and Benzyl Ester and Normal Saline as subcutaneous injection daily for 60 days. Next, samples of testicular fixative were stained by the usual method (H&E) and Histological parameters of seminiferous tubules were measured through stereometry and morphometry methods. Reduce the Diameter and Perimeter of seminiferous tubules in the group of Benzyl Ester had significant difference with the two other groups while there was not noticeable difference among the three studied groups in terms of seminiferous tubules number. Benzyl ester was more effective on Histological parameters of seminiferous tubules. Thus, with eliminating the cardiovascular effects and Conservation the contraceptives properties, it can be used as a guide combination.

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