Antioxidant Effects of 6-gingerol on Serum Levels of Liver Enzymes and Oxidative Stress-induced Markers with Gold Nanoparticles in Rat Liver Tissue

Subject Areas : Journal of Animal Biology

BibiFatemeh Fatemi ¹ , Gholamhassan Vaezi ² , Shahram Sharafi ³ , Raheleh Rahbarian ⁴

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4 - Department of Biology, Payame-Noor University, Mashhad, Iran

Received: 2021-05-26 Accepted : 2021-08-11 Published : 2022-02-20

Keywords: liver, Oxidative stress, Rats, Gold nanoparticles, Gingerol,

Abstract :

Gold nanoparticles disturb the physiological processes of the liver tissue by affecting the body’s biological system. Given gingerol's antioxidant properties, researchers wanted to see how it affected the levels of liver enzymes and oxidative stress indices in the liver tissue of rats exposed to gold nanoparticles.This experimental research was conducted on 32 male Wistar rats, divided into four equal groups of control, gold nanoparticle (one administration of 0.5 ml gold nanoparticle, 200 ppm and 60 nanometers), gold nanoparticles + 50 mg/kg concentration of gingerol, and gold nanoparticles + 100 mg/kg gingerol. At the end of treatment period, the serum level of ALT, AST, GGT, ALP, and level of antioxidant enzymes of SOD < GST, and CAT, and levels of MDA and HOdG-8 in the liver tissue were measured using the ELISA method. In this study, rats receiving gold nanoparticles with concentrations of 50 and 100 mg/kg gingerol had significantly higher levels of SOD, GST, and CAT enzymes in their liver tissue than the dose-dependent group receiving gold nanoparticles. The serum levels of ALT, AST, GGT, and ALP, on the other hand, were reduced. Furthermore, the levels of MDA and HOdG-8 in rat liver tissue were found to be significantly lower (P <0.001).According to the results of study, gingerol improved the oxidative stress indices in liver tissue and decreased the serum level of liver enzymes. Therefore, this compound can be exploited to reduce DNA oxidative stress and lipid peroxidation in liver tissue.

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