The Effect of a Short Period of Detraining Following the Six Weeks of High Intensity Interval Training on HIF-1α Levels and Bronchus and Bronchioles Apoptosis in Lung Tissue in Male Wistar Rats

Subject Areas : Journal of Animal Biology

Saber Niazi ¹ , Shadmehr Mirdar ² , Reza Bazzar ³ , Gholamreza Hamidian ⁴

1 - Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
2 - Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
3 - Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
4 - Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Received: 2021-04-14 Accepted : 2021-09-11 Published : 2022-02-20

Keywords: Apoptosis, High Intensity Interval Training, Hypoxia inducible factor-1α, Detraining, Lung tissue, Bronchus, Bronchioles,

Abstract :

This study aimed evaluate the effect of short-term detraining following 6 weeks of high-intensity interval training on HIF-1α, bronchus, and bronchioles apoptosis levels on lung tissue in male Wistar rats. For this purpose, 18 healthy Wistar male rats (4 weeks with a mean weight of 72±9.9 g) were divided into experimental (n=12) and control (n=6) groups. After 6 weeks of high-intensity interval training, 6 rats the experimental group was transferred to the detraining group (n=6) and kept in detrain condition for three weeks. To measure of HIF-1α and bronchus and bronchioles apoptosis, a lung tissue sample was taken and measured at the end of the ninth week. One-way analysis of variance at the significance level (P≤0.05) was used to analyze the data. The results showed that despite the significant increase in HIF-1α and bronchial apoptosis and pulmonary bronchioles (P≤0.05) during high-intensity training, there was a significant decrease (P ≤ 0.05) in HIF-1α, bronchial apoptosis and bronchioles of lung tissue were observed. It seems to be done by the increase of the amount of HIF-1α and apoptosis in multiple cell lung bronchi and bronchioles, but the detraining period will decrease..

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