Activation and Inhibition Comparing of GABAB Receptor on Memory in the Basolateral Amygdala (BLA)

Subject Areas : Journal of Animal Biology

M. Khakpoor ¹ , M.R. Zarrindast ² , A. Vahdati ³ , M. Nasehi ⁴ , S.E. Hoseyni ⁵

1 - گروه زیست شناسی، واحد علوم و تحقیقات فارس، دانشگاه آزاد اسلامی، فارس، ایران گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
2 - مرکز علوم و اعصاب شناخت، واحد تهران پزشکی دانشگاه آزاد اسلامی، تهران، ایران
3 - گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
4 - مرکز علوم و اعصاب شناخت، واحد تهران پزشکی دانشگاه آزاد اسلامی، تهران، ایران
5 - گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران

Received: 2016-10-15 Accepted : 2017-05-21 Published : 2016-11-21

Keywords: BLA, Baclofen, Phaclofen, GABA, Step-through,

Abstract :

Studies have shown that γ-aminobutyric acid (GABA) neurotransmitter can effect in the modulation of learning and memory in the basolateral amygdala (BLA). The aim of this study was to investigate, the effect of GABAB receptor agonist and antagonist in the BLA on memory, in male Wistar rats in a step-through type passive avoidance.  In this study, male Wistar rats weighing 240–270 g were used. After guide cannulae were bilaterally placed in the BLA, animals were trained in a step-through type passive avoidance task and then tested 24 h after training to measure memory retrieval and locomotor activity. Post-training intra-BLA microinjection of GABAB receptor agonists baclofen (0.01 μg/rat) or GABAB receptor antagonists phaclofen (0.01 μg/rat) decreased step-through latency during retrieval but did not alter locomotor activity. In conclusion, baclofen and phaclofen decreased consolidation of memory formation in the BLA, and GABAB receptors in the BLA may be involved in the memory consolidation deficits.