Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography

Subject Areas :

فرشته  شیری ¹ (استادیار گروه شیمی، دانشکده علوم، دانشگاه زابل، زابل، ایران)
به‌شاره  هاشمی ² (دکترای شیمی تجزیه دانشکده شیمی، دانشگاه رازی، کرمانشاه، ایران)
ایمان  فضلی‌پور ³ (کارشناس ارشد شیمی، دانشکده علوم، دانشگاه زابل، زابل، ایران)
مسعود  نجاتی یزدی نژاد ⁴ (استادیار گروه شیمی، دانشکده علوم، دانشگاه زابل، زابل، ایران)

Received: 2017-04-22 Accepted : 2017-08-24 Published : 2018-11-22

Keywords: Experimental design, Atorvastatin, dispersive liquid- liquid microextraction,

Abstract :

A simple, rapid, and inexpensive dispersive liquid-liquid microextraction based on solidification of organic drop (DLLME-SFO) combined with high-performance liquid chromatography was developed for the extraction and determination of trace levels of atorvastatin (ATV) in tablet. Effect of variables such as extracting and dispersive solvent volume and pH were investigated simultaneously using experimental design. Under the optimum conditions, the calibration graph was linear in the range of 1-200 μg L-1 with the detection limit of 0.3 μg L-1. The optimized method revealed a good precision with relative standard deviation (RSD) of2.2 %.The performance of the method was evaluated for extraction and determination of ATV in tablet sample. The results of this study revealed that the proposed method gives high extraction efficiency and low LOD. The most important advantage of this technique is that the use of large sample volumes and toxic organic solvents have been omitted.

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