Effect of oral tramadol on rat Spleen tissue in male Wistar rats

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

sahar  molzemi ¹ (Department of Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Shahroud Branch, Shahroud, Iran)
mohsen  aminian ² (Assistant Professor, Department of Internal Medicine, School of Medicine, Army University of Medical Sciences, Tehran, Iran)
Mohammad  Afshar Ardalan ³ (Assistant Professor, Department of Internal Medicine, School of Medicine, Army University of Medical Sciences, Tehran, Iran)
Amir Hossein  Ashnaei ⁴ (Department of Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Shahroud Branch, Shahroud, Iran)

Received: 2020-11-30 Accepted : 2021-06-17 Published : 2021-05-22

Keywords: Rats, spleen, Mouse, : tramadol, Wistar,

Abstract :

Introduction : Tramadol the right drugs are synthetic opioid analgesics or Epoxied. The aim of this study was to evaluate the effect of oral tramadol on Spleen in rats Wistar male rats.Methods: In this study, 60 male Wistar rats randomized into 3 groups (1 control group, and experimental groups of 1, 2). In control group adequate serum physiology and in experimental groups a dose of mercuric chloride infused into peritoneal cavity, for 30 days. The amount of gavage tramadol were, 50ml /kg group 2, 100 ml /kg , every other day for 30 days. After the end of the day appointed for Histological analysis Some blood parameters of Spleen samples, were tested.Results :And & two experimental groups a very high density and exposure area is full of blood and lymphoid cells. Particles of hemosiderin in both groups showed a significant increase..Conclusion: This study showed that long-term oral administration of Tramadol causes histological changes in the SpleenKeywords: tramadol, Spleen, mouse, rats, Wistar