-
حرية الوصول المقاله
1 - Electrocatalytic Synthesis of Spirooxindole-Chromene Derivatives in Ethanol/DMSO Media using a Fe-Mn-O Composite as an Efficient Working Electrode
Mohaddeseh Taheri Behrooz Mirza Mohsen ZeebAn efficient and sustainable method was developed for electrocatalytic multicomponent synthesis of spirooxindole-chromene derivatives via a green one-pot, three component condensations of cyclic-1,3-diones, malononitrile and isatins inside an undivided cell where potass أکثرAn efficient and sustainable method was developed for electrocatalytic multicomponent synthesis of spirooxindole-chromene derivatives via a green one-pot, three component condensations of cyclic-1,3-diones, malononitrile and isatins inside an undivided cell where potassium bromide was applied as electrolyte in ethanol/DMSO (95/5 v/v) media, and a practical Fe-Mn-O composite was used as cathode electrode. The presented electrosynthesis approach proved to be reliable and cost-effective for the synthesis of target compounds in 83-91% yields. In this method, we highlight the utility of electrosynthesis method for the preparation of diverse spirooxindole-chromen derivatives that can be a breakthrough for production of vital drugs. تفاصيل المقالة -
حرية الوصول المقاله
2 - H6P2W18O62: A Green and Reusable Catalyst for the One-pot Three-Component Synthesis of Spirooxindoles in Water
Zahra Lasemi Ebrahim MehrasbiWells–Dawson tungsten heteropolyacid (H6P2W18O62) has been applied as an effective heterogeneous catalyst for one-pot synthesis of spiro[4H-pyran-3,3’-oxindoles] via reaction of various isatins, malonitrile and 1,3-dicarbonyl compound in water. The corresp أکثرWells–Dawson tungsten heteropolyacid (H6P2W18O62) has been applied as an effective heterogeneous catalyst for one-pot synthesis of spiro[4H-pyran-3,3’-oxindoles] via reaction of various isatins, malonitrile and 1,3-dicarbonyl compound in water. The corresponding products were obtained in high yields. The catalysts were easily recycled and reused without loss of their catalytic activity. تفاصيل المقالة -
حرية الوصول المقاله
3 - Synthesis and characterization of Nanoparticles Poly Ethylene Imine-Functionalized MCM-41by Covalent Anchoring as a Solid Catalyst for Multi-Component Reactions
Hosein Hamadi Maryam Gholami Mehdi KhoobiA novel magnetically immobilized polyethyleneimine (PEI) fabricated by covalently anchoring on MCM-41 (MCM-41@PEI) was prepared. The synthesized catalyst was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), X-ray powder diffraction أکثرA novel magnetically immobilized polyethyleneimine (PEI) fabricated by covalently anchoring on MCM-41 (MCM-41@PEI) was prepared. The synthesized catalyst was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The immobilized PEI was shown to be an efficient heterogeneous catalyst for the synthesis of spiro-oxindole and benzopyranes derivatives via multi-component reaction (MCR), in ethylene glycol as a green solvent. No leaching problem was observed after several runs, while the catalyst can be recovered and reused without loss of reactivity under the described reaction conditions. تفاصيل المقالة -
حرية الوصول المقاله
4 - Fabrication of HPA-ZSM-5 and their successful application to the recyclable heterogeneous catalyst for the smooth synthesis of spiro-pyrido-pyrimidine indoline derivatives
Javad SafaeiGhomi Mohammaed Mutashar Raheleh TeymuriA beneficial and efficient one-pot three-component approach for the synthesis of spiro cyclic 2-oxindole derivatives has been described by the reaction of isatins, cyclic-1,3-diketones and 6-amino-1,3-dimethyluracil in presence of highly active HPA-ZSM-5 microporous cat أکثرA beneficial and efficient one-pot three-component approach for the synthesis of spiro cyclic 2-oxindole derivatives has been described by the reaction of isatins, cyclic-1,3-diketones and 6-amino-1,3-dimethyluracil in presence of highly active HPA-ZSM-5 microporous catalyst. The zeolite catalyst has been synthesized and the catalyst has been thoroughly characterized by X-ray diffraction (XRD), field emission scanning electronic microscopy (FE-SEM), Fourier transform infrared (FT-IR), energy dispersive spectroscopy (EDS) and N2-adsorption analysis. HPA-ZSM-5 catalyst exhibited exceptional recyclability at least for 6 times and the surface acidity was not significantly changed. The best results were gained in H2O and we found the convincing results for the synthesis of spiro-pyrido-pyrimidine in the presence of HPA-ZSM-5 (10 mg) under ultrasound irradiation (40W). Experimental simplicity, wide range of products, excellent yields in short reaction times and low catalyst loading are some of the substantial features of this procedure. The present catalytic method is extensible to a wide diversity of substrates for the synthesis of a variety-oriented library of spiro-pyrido-pyrimidine indoline derivatives. تفاصيل المقالة -
حرية الوصول المقاله
5 - Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst for the synthesis of oxindoles
Hossein Shahbazi-Alavi Javad Safaei-GhomiCross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as an efficientheterogeneous solid acid catalyst has been used for the preparation of spiro[pyrazoloquinoline-oxindoles]and spiro[chromenopyrazolo-oxindoles] through a four-component reaction أکثرCross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as an efficientheterogeneous solid acid catalyst has been used for the preparation of spiro[pyrazoloquinoline-oxindoles]and spiro[chromenopyrazolo-oxindoles] through a four-component reactions of phenylhydrazineor hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux conditions inethanol. The remarkable advantages of this methodology are easy work-up, short reaction times, highto excellent product yields, operational simplicity, low catalyst loading and reusability of the catalyst. تفاصيل المقالة -
حرية الوصول المقاله
6 - Fabrication of HPA-ZSM-5 and their successful application to the recyclable heterogeneous catalyst for the smooth synthesis of spiro-pyrido-pyrimidine indoline derivatives
Javad SafaeiGhomi Mohammaed Abdulridha Mutashar Raheleh TeymuriA beneficial and efficient one-pot three-component approach for the synthesis ofspiro cyclic 2-oxindole derivatives have been described by the reaction of isatins,cyclic-1,3-diketones and 6-amino-1,3-dimethyluracil in the presence of highlyactive HPA-ZSM-5 microporous c أکثرA beneficial and efficient one-pot three-component approach for the synthesis ofspiro cyclic 2-oxindole derivatives have been described by the reaction of isatins,cyclic-1,3-diketones and 6-amino-1,3-dimethyluracil in the presence of highlyactive HPA-ZSM-5 microporous catalyst. The zeolite catalyst has been synthesizedand the catalyst has been thoroughly characterized by X-ray diffraction (XRD),field emission scanning electronic microscopy (FE-SEM), Fourier transforminfrared (FT-IR), energy dispersive spectroscopy (EDS) and N2-adsorption analysis.HPA-ZSM-5 catalyst exhibited exceptional recyclability at least for 6 times andthe surface acidity was not significantly changed. The best results were gainedin H2O and we found the convincing results in the synthesis of spiro-pyridopyrimidinein the presence of HPA-ZSM-5 (10 mg) under ultrasound irradiation(40W). Experimental simplicity, wide range of products, excellent yields in shortreaction times and low catalyst loading are some of the substantial features ofthis procedure. The present catalytic method is extensible to a wide diversity ofsubstrates for the synthesis of a variety-oriented library of spiro-pyrido-pyrimidineindoline derivatives. تفاصيل المقالة -
حرية الوصول المقاله
7 - Synthesis of spirooxindole derivatives catalyzed by Fe (III)@graphitic carbon nitride nanocomposite via one-pot multi-component reaction
Ali Allahresani Bahare Taheri Mohammad Ali NasseriFe (III) supported graphitic carbon nitride nanocomposite was synthesized by impregnation of FeCl3 with g- C3N4 (Fe (III)@g-C3N4). Then, the synthesis of spirooxindole derivatives was carried out in the presence of Fe (III) @ graphitic carbon nitride nanocompositevia th أکثرFe (III) supported graphitic carbon nitride nanocomposite was synthesized by impregnation of FeCl3 with g- C3N4 (Fe (III)@g-C3N4). Then, the synthesis of spirooxindole derivatives was carried out in the presence of Fe (III) @ graphitic carbon nitride nanocompositevia the multi-component reaction of malononitrile, isatins, and 1,3-dicarbonyl compounds in green media (ethanol/water (1:1)) under reflux conditions and the corresponding products were prepared in good to excellent yields (70-98 %). Also, the heterogeneous nanocatalyst was characterized by different techniques including the transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), atomic absorption spectroscopy (AAS) and X-ray diffraction (XRD). Furthermore, the nanocomposite is recoverable and reusable several times without a negligible decrease in its catalytic performance. تفاصيل المقالة -
حرية الوصول المقاله
8 - D-phenyl alanine-oxalic acid (D-Phe-Ox): A novel nano ionic liquid catalyzing the one-step green synthesis of functionalized spirolactones and dispirodihydro-furanyl oxindoles
Kobra Nikoofar Shiva KhaniIn this paper, a new nano-size ionic liquid (nIL) has been synthesized from D-phenylalanine and oxalic acid (D-Phe-OX) via a simple procedure. The obtained nIL has been characterized by the fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectro أکثرIn this paper, a new nano-size ionic liquid (nIL) has been synthesized from D-phenylalanine and oxalic acid (D-Phe-OX) via a simple procedure. The obtained nIL has been characterized by the fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDAX), thermogravimetric analysis (TGA), nuclear magnetic resonance spectroscopy (1H NMR), and field emission scanning electron microscopy (FESEM), techniques. The synthesized nanocatalyst has been used for the three-component one-step synthesis of functionalized spirolactones via the condensation reaction of arylamines, DMAD and isatins. The stereoselective preparation of dispirodihydrofuranyl oxindoles has also been examined successfully through the one-step pseudo-four component condensation of isatins, amines and DMAD, respectively. تفاصيل المقالة -
حرية الوصول المقاله
9 - Diethylenetriamine supported on cellulose as a biodegradable and recyclable basic heterogeneous catalyst for the synthesis of spirooxindole derivatives
Batol Zakerinasab Mohammad Ali Nasseri Ali AllahresaniIn the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. Then, the applicability of the synthesized catalyst cellulose bonded N-propyl diethylene triamine (CBPDETA) أکثرIn the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. Then, the applicability of the synthesized catalyst cellulose bonded N-propyl diethylene triamine (CBPDETA) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. A various series of tetrahydrospiro-[chromene-indoline]-carbonitrile and dihydro-spiro[pyrano quinoline--indoline]-carbonitrile are obtained in water, an excellent solvent in terms of environmental impact, in high yield (78- 98%) from one-pot reaction procedure involving dicarbonyl/ 4-hydroxycoumarine , malononitrile and isatin compounds. The catalyst has been reused several times, without observable loss of activity and selectivity. تفاصيل المقالة -
حرية الوصول المقاله
10 - Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity
Leila Youseftabar-Miri Maryam RafieiradThe ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenab أکثرThe ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity, i try to submit paper) تفاصيل المقالة -
حرية الوصول المقاله
11 - Synthesis, characterization and immobilization of cobalt (III) salen complex on CoFe2O4@SiO2 nanoparticle and their application in the synthesis of di-indolyloxindole
Kaveh Hemmat Mohammad Ali Nasseri Ali AllahresaniThe preparation, characterization, and immobilization of cobalt (III) salen complex on CoFe2O4@SiO2 nanoparticle (CoFe2O4@SiO2@ Co(III) salen complex) are described. Co(III) salen complex loaded on ferrite cobalt-silica nanoparticle is characterized by TEM, SEM-EDX, VSM أکثرThe preparation, characterization, and immobilization of cobalt (III) salen complex on CoFe2O4@SiO2 nanoparticle (CoFe2O4@SiO2@ Co(III) salen complex) are described. Co(III) salen complex loaded on ferrite cobalt-silica nanoparticle is characterized by TEM, SEM-EDX, VSM and FT-IR analyses. The efficiency of CoFe2O4@SiO2@Co(III) salen complex as a catalyst was carried out in the 3-indolylation reaction of indole with isatin derivatives in the water at 80 . Di-indolyloxindole was achieved with excellent yield (95%), using indole, isatin, and CoFe2O4@SiO2@Co(III) salen complex within 2 h in water as solvent at 80 . Moreover, the recoverability and reusability of CoFe2O4@SiO2@Co(III) salen complex were investigated. تفاصيل المقالة -
حرية الوصول المقاله
12 - Fe3O4@SiO2@IL‐PVP magnetic nanoparticles: Effective synthesis of spirooxindoles
Shahla Veysipour Masoud Nasr-Esfahani Zahra Rafiee Behrouz Eftekhari farVarious magnetite heterogeneous catalysts for the organic reaction are increasingly recognized while their stability still is a critical challenge. In this regard, SiO2, ionic liquid (IL), and polyvinyl pyrrolidone (PVP) were applied as a three-layer stabilization syste أکثرVarious magnetite heterogeneous catalysts for the organic reaction are increasingly recognized while their stability still is a critical challenge. In this regard, SiO2, ionic liquid (IL), and polyvinyl pyrrolidone (PVP) were applied as a three-layer stabilization system for modifying magnetic Fe3O4 to produce Fe3O4@SiO2@IL‐PVP as a novel nanocatalyst. The Fe3O4@SiO2@IL‐PVP as stabilized heterogeneous catalysts were utilized in a robust, and environmentally friendly strategy for the preparation of the spirooxindole derivatives by the one-pot condensation of isatin, malononitrile, and 1,3-dicarbonyl in a water solvent. The proposed method revealed a high yield spirooxindole derivatives preparation (99%) at short reaction times (1.0 min), low catalyst mass (0.002 g), and satisfactory temperature (30 °C) which confirm the lack of any tedious challenge and promising applicability and reusability. This work introduces a rational core-shell nanosystem design with a facile and novel construction strategy to arrive at nonexquisite metal-based composite catalysts with superior catalytic proficiency and prominent long-term stability. تفاصيل المقالة -
حرية الوصول المقاله
13 - Selective and efficient synthesis of 3-indolyl-2-oxindoles under catalysis of LiClO4
Kurosh Rad-Moghadam Shaghayegh GholizadehAn efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. The syntheses were achieved selectively under catalysis of LiClO4 whereby the products were obtained purely.An efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. The syntheses were achieved selectively under catalysis of LiClO4 whereby the products were obtained purely. تفاصيل المقالة -
حرية الوصول المقاله
14 - Studies on Mechanism of Formation and Medicinal applications of structurally diverse Indole and Oxindole derivatives
Noor ud Din Zargar Khaliq Zaman KhanThe field of heterocyclic chemistry is vast and has played a significant role in synthetic organic chemistry. Heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal and pharmaceutical research. Indoles and Oxindoles are the most stud أکثرThe field of heterocyclic chemistry is vast and has played a significant role in synthetic organic chemistry. Heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal and pharmaceutical research. Indoles and Oxindoles are the most studied bicyclic nitrogen heterocycles. The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. A chemoselective N-acylation of indoles1 using thioesters 2 as a stable acyl source has been reported. Interaction of 1-acylindoles 10 with acetyl chloride in the presence of AlCl3 yields the corresponding 1- acyl-3-acetylindoles 11 which upon hydrolysis affords 3-acetylindole12.Addition of (1Hindol- 3-yl) magnesium iodide (16) to 2-(benzyloxy) acetyl chloride 17 in diethyl ether forms 3-benzyloxyacetylindole 18. Acylation of Oxindole 20 with chloroacetyl chloride affords 5- chloromethyl ketone derivatives31whichwhen treated with thioureas and thioamides leads to the formation of 5-thiazole oxindoles32.This article focuses on various synthetic methods and suggested mechanism of different indole and oxindole derivatives.Apart from this, applications of medicinal importance of these heteroatom compounds have also been discussed. تفاصيل المقالة
سند
Sanad is a platform for managing Azad University publications
الروابط
المراكز ذات الصلة
دعامة
الصفحات الرسمية
حقوق هذا الموقع الإلكتروني مملوكة لنظام SANAD Press Management. © 1442-1446