Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity
الموضوعات : Iranian Journal of Catalysis
Leila Youseftabar-Miri
1
,
Maryam Rafieirad
2
1 - Department of Chemistry, Izeh Branch, Islamic Azad University, Izeh, Iran
2 - Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
الکلمات المفتاحية: Ionic Liquid, Isatin, Henry reaction, Oxindole,
ملخص المقالة :
The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity, i try to submit paper)
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