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حرية الوصول المقاله
1 - One-pot Synthesis of 2-amino-4H-chromene Derivatives as Potential Antimicrobial Agents using DABCO-CuCl Complex as an Effective Catalyst
Bita Baghernejad Samaneh KooshaA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuC أکثرA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an effective catalyst at room temperature. The structures of synthesized compounds were characterized by techniques of IR,1H-NMR, Mass and elemental analysis. This method provides an efficient improved pathway for the synthesis of chromenes in the terms of excellent yields, short reaction times and reusability catalyst. تفاصيل المقالة -
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2 - One-pot Synthesis of Amidoalkyl Naphthol Derivatives as Potential Nucleoside Antibiotics and HIV Protease Inhibitors using Nano-SnO2 as an Efficient Catalyst
Bita Baghernejad Elham AshooriAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were character أکثرAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were characterized by IR, 1HNMR, 13C-NMR, and Mass spectra and by elemental analysis. The advantages of the effective method were good yields, short reaction times, simple work-up, eco-friendly solvent, and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without much loss in its activity. تفاصيل المقالة -
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3 - A simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide
Farzaneh MohamadpourAn eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, arom أکثرAn eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) under solvent-free conditions in high yields. The advantages of this one-pot procedure is environmentally friendly, efficient and economic availability of the catalyst, short reaction times, solvent-free conditions and clean reaction profiles. تفاصيل المقالة -
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4 - One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Mohsen Sargordan Arani Behrooz Mirza Mohammad MoghanlouThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been c أکثرThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy تفاصيل المقالة -
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5 - A Novel, Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine Derivatives Under Solvent-Free Conditions
Tayebeh Sanaeishoar Mitra SaremiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
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6 - Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine
Haleh Sanaeishoar Mitra SeramiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
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7 - Cellulose nanocrystal functionalized palladium nanoparticles as an efficient heterogeneous catalyst for the synthesis of α-amino nitriles via Strecker reaction
Atieh Mirosanloo Daryoush Zareyee Mohammad KhalilzadehAn efficient route reported to the application of palladium nanoparticles dispersed on 2-aminopyrimidine functionalized cellulose nanocrystal (CNC-AMPD-Pd) as a novel, suitable and reusable catalyst in the one-pot, three component synthesis of different α-aminonit أکثرAn efficient route reported to the application of palladium nanoparticles dispersed on 2-aminopyrimidine functionalized cellulose nanocrystal (CNC-AMPD-Pd) as a novel, suitable and reusable catalyst in the one-pot, three component synthesis of different α-aminonitriles at ambient temperature under solvent free reaction conditions. The heterogeneous catalyst could be easily separated from the reaction mixture and reused at least 6 times with no significant loss of catalytic activity. تفاصيل المقالة -
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8 - One-pot synthesis of tri- and tetrasubstituted imidazoles using nano-LaMnO3 perovskite-type oxide as reusable heterogeneous catalyst in solvent-free condition
Haleh Sanaeishoar Haman Tavakkoli Mahsa Asareh Fouad MohaveA convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacte أکثرA convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method. تفاصيل المقالة -
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9 - One-pot pseudo-five-component synthesis of dihydropyrano[2,3-g] chromenes using sodium phthalimide/[BMIM]BF4 as high efficient catalytic system
Leila Moradi Maryam Aghamohammad SadeghAn efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium pht أکثرAn efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium phthalimide and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) ionic liquid (SPI/IL) was studied. The reaction products were characterized using 1H NMR, 13C NMR, FTIR, Mass spectroscopy and elemental analysis. Environmentally eco-friendly catalyst, clean reaction with easy work-up (through simple filtration) and high yield products with no more purification are the main merits of this protocol. Presented method can be used for the synthesis of mentioned products (with pharmacology and Biologic properties) in large scales. تفاصيل المقالة -
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10 - Employing a hydrophobic-bentonite as a highly efficient and versatile catalyst for a green one-pot and rapid synthesis of 4H-benzo-[b]-pyran derivatives
Mohammad Ebrahim Sedaghat Faranak Farhadi Mohammad Reza Nazarifar Rezvan Sheikhi KamarejiA hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na&nda أکثرA hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na–bentonite with cetyltrimethyl ammonium bromide (CTMAB) cations. The catalyst was characterized by XRD, BET and SEM. The BET data and XRD patterns showed that the surfactant ions enter the interlayer space of catalyst. In order to study the catalytic properties, we carried out a one-pot practical, efficient and green multicomponent synthesis of 4H-benzo-[b]-pyran derivatives in terms of high yield, simple experimental procedure, low reaction time and simple work-up. تفاصيل المقالة -
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11 - Highly efficient one-pot four-component synthesis of polyhydroquinoline derivatives catalyzed by stannous chloride under solvent-free conditions
Surekha Deshmukh Jitendra Gujar Ramrao Mane Murlidhar ShingareA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solv أکثرA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solvent free condition to synthesize a variety of polyhydroquinoline derivatives in good to excellent yields. Stannous chloride was proved to be an efficient heterogeneous Lewis acid catalyst, which could be relatively non-toxic, inexpensive, possess good thermal stability and easy to handle. The present method provides several advantages such as mild reaction conditions, green methodology, inexpensive catalyst, simple work-up procedure, short reaction time and high yields. تفاصيل المقالة -
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12 - Kaolin-SO3H as an efficient catalyst for one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Bi Bi Fatemeh Mirjalili Hamidreza AkramiKaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and bi أکثرKaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, antibacterial, antitumor and inhibitors of the p38 MAP kinase. A simple, highly versatile and efficient synthesis of 1,2,4,5-tetrasubstituted imidazoles is achieved using Kaolin-SO3H as a catalyst at moderate temperature under solvent free condition. The key advantages of this process are high yields with simple work-up using easy available inexpensive natural based catalyst. تفاصيل المقالة -
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13 - An efficient synthesis of 4-aryl-7-benzylidene-hexahydro-2H-cyclopenta[d] pyrimidin-2-ones/thiones catalyzed by p-dodecylbenzenesulfonic acid
Krishnamoorthy Aswin Majid Ghashang Sheik MansoorA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic أکثرA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic acid (DBSA) as a recyclable catalyst under solvent-free condition. The recovered catalyst was recycled for further runs. The product formation takes place via a cross-aldol condensation of benzaldehyde with cyclopentanone in the presence of DBSA to produce benzylidene intermediate and subsequent Michael addition. The present approach offers the advantages of short reaction time, mild reaction conditions, high yields and convenient operation. All the products were obtained in good to excellent yields and the structures of the synthesized compounds were established by advanced spectroscopic data. تفاصيل المقالة -
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14 - Bi(NO3)3.5H2O: An efficient acidic reagent for synthesis of azo dyes at room temperature
Bi Bi Fatemeh Mirjalili Abdolhamid Bamoniri Naimeh SalehiAn one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of Bi(NO3)3. 5H2O. Short reaction times, high yields, a clean process, simple أکثرAn one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of Bi(NO3)3. 5H2O. Short reaction times, high yields, a clean process, simple methodology, easy work-up and green ‎conditions are advantages of this protocol.‎ تفاصيل المقالة -
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15 - One-pot synthesis of 2,4,5-trisubstituted imidazoles catalyzed by dicationic magnetic room temperature ionic liquid
Bijan Mombani Godajdar Ali Reza KiasatRegarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperatu أکثرRegarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperature ionic liquid catalyst in the one-pot three-components condensation reaction of benzil, aromatic aldehyde, and ammonium acetatate are also described. Utilization of easy reaction conditions, catalyst with high catalytic activity and good reusability, and simple magnetically work-up, makes this methodology as an interesting option for the synthesis of 2,4,5-trisubstituted imidazoles. تفاصيل المقالة -
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16 - Green procedure for synthesis of 3, 4 dihydropyrimidinones using 12-molybdophosphoric acid, as a catalyst and solvent free condition under microwave irradiation
Hojjatollah SalehiSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions wer أکثرSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions were performed under solvent free conditions with microwave irradiation as the energy source. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (76–96%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and friendly preparation. Products were identified using physical and spectroscopic data. تفاصيل المقالة