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حرية الوصول المقاله
1 - بررسی واکنشهای چند جزئی مرتبه بالا و کاربردهای بیولوژیکی محصولات آنها
جواد صفایی قمی سیما کلهر زهرا کلهرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این أکثرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این واکنشها که باعث تغییر و تحول اساسی در سنتز همه محصولات طبیعی شده؛ با سرعت زیادی در طول چند دهه گذشته گسترشیافته است. تا امروز بسیاری از واکنشهای جدید سه و چهارجزئی معرفیشدهاند؛ درصورتیکه نمونههایی از واکنشهای "مرتبه بالاتر" که در آن پنج یا حتی تعداد اجزاء بیشتری در ظرف واکنش باهم ترکیب میشوند، به شکل قابلملاحظهای کمتر بررسی شده است. در پایان قرن بیستم با افزایش مزیتهای "مولکولهای بیولوژیک فعال" ، بررسی کاربرد این واکنشها برای تهیهی "مولکولهای کوچک شبه دارویی" در صنایع و دانشگاهها افزایش یافته است. از مزیتهای این روش نسبت به روشهای دیگر، استفاده از مواد اولیه در دسترس، کمهزینه بودن، روش کار ساده، طیف گسترده کالا، ایجاد تنوع بالا در چند مرحله، سهولت اتوماسیون و... میباشد. هدف از این بررسی، توصیف تحولات ایجادشده در سالهای اخیر، ایدهها، چالشها و ارائه پیشنهادهایی برای پیشرفت در این زمینه میباشد. تفاصيل المقالة -
حرية الوصول المقاله
2 - Green Synthesis and Investigation of Antioxidant Activity of New Quinoline Derivatives
Seyyed Ali Moghaddas Zinatossadat Hossaini Daryoush ZareyeeNew derivatives of furo[2,3-f]quinoline derivatives in high yields using multicomponent reaction ofthe 2-amino-4-hydroxyacetophenone, isopropenylacetylene, aldehydes and malononitrile or ethylcyanoacetate in the presence of catalytic amounts of Fe3O4/KF/Clinoptilolite@M أکثرNew derivatives of furo[2,3-f]quinoline derivatives in high yields using multicomponent reaction ofthe 2-amino-4-hydroxyacetophenone, isopropenylacetylene, aldehydes and malononitrile or ethylcyanoacetate in the presence of catalytic amounts of Fe3O4/KF/Clinoptilolite@MWCNTs magneticnanocomposites using ionic liquid as green solvent at room temperature were synthesized. Thiscatalyst could be employed several times in these reactions and have the main role in the yield ofthe product. The synthesized compounds have NH group in their structure and for this reason, havegood antioxidant activity. Our procedure for preparation of furo[2,3-f]quinoline derivatives hassome advantages such as low reaction time, the product with high yields, and simple separation ofcatalyst and products. تفاصيل المقالة -
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3 - One-pot Synthesis of 2-amino-4H-chromene Derivatives as Potential Antimicrobial Agents using DABCO-CuCl Complex as an Effective Catalyst
Bita Baghernejad Samaneh KooshaA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuC أکثرA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an effective catalyst at room temperature. The structures of synthesized compounds were characterized by techniques of IR,1H-NMR, Mass and elemental analysis. This method provides an efficient improved pathway for the synthesis of chromenes in the terms of excellent yields, short reaction times and reusability catalyst. تفاصيل المقالة -
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4 - One-pot Synthesis of Amidoalkyl Naphthol Derivatives as Potential Nucleoside Antibiotics and HIV Protease Inhibitors using Nano-SnO2 as an Efficient Catalyst
Bita Baghernejad Elham AshooriAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were character أکثرAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were characterized by IR, 1HNMR, 13C-NMR, and Mass spectra and by elemental analysis. The advantages of the effective method were good yields, short reaction times, simple work-up, eco-friendly solvent, and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without much loss in its activity. تفاصيل المقالة -
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5 - One-pot Four-component Reaction for Convenient Synthesis of New Quinoxaline Derivatives in the Presence of K2CO3
Sama Taherjoo Anvar MirzaeiConvenient and simple procedures for the synthesis of functionalized Quinoxaline derivatives were developed via one-pot four-component reaction of o-aminoanilin, acetylenic ester, and malonyl dichloride in the presence of K2 CO3 as effective base catalyst. These compoun أکثرConvenient and simple procedures for the synthesis of functionalized Quinoxaline derivatives were developed via one-pot four-component reaction of o-aminoanilin, acetylenic ester, and malonyl dichloride in the presence of K2 CO3 as effective base catalyst. These compounds widely are used in various industries like paint, pharmaceutical and medicine. Quinoxaline derivatives are also part of antibiotics structure such as Actinomycin, Lomacin. In other hand, using of K2 CO3 as economically catalyst and the simplicity of the present procedure for synthesis of Quinoxaline derivatives makes it an interesting alternative to complex multistep approaches.. The structures of the newly synthesized compounds were confirmed by their elemental analysis and spectral data. تفاصيل المقالة -
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6 - Application of H2O as the Green Solvent for the Synthesis of Phosphonates via Multicomponent Reactions
Fatemeh Sheikholeslami-FarahaniPhosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields.Phosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields. تفاصيل المقالة -
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7 - Application of Green Chemistry in the Synthesis of Thiopyran Derivatives
Fatemeh Sheikholeslami-FarahaniAn efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. Th أکثرAn efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. The method offers several advantages including high yields of products and an easy work-up procedure. تفاصيل المقالة -
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8 - Caro’sacid-silicagel: An Efficient and Reusable Catalyst for the Synthesis of 2, 4, 5- Trisubstituted Imidazoles under Solvent-free Conditions
Khalil Pourshamsian Naser Montazeri Sadegh AsadyanCaro’s acid-silicagel was found to be a mild and effective catalyst for the one –pot multicomponent condensation of benzyl, aldehydes and ammonium acetate used for synthesis of 2, 4, 5-trisubstituted imidazole derivatives under solvent–free conditions. أکثرCaro’s acid-silicagel was found to be a mild and effective catalyst for the one –pot multicomponent condensation of benzyl, aldehydes and ammonium acetate used for synthesis of 2, 4, 5-trisubstituted imidazole derivatives under solvent–free conditions. This catalyst has several advantages such as simple work-up, low cost and reusability. تفاصيل المقالة -
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9 - Deep Eutectic Solvent Based on Choline Chloride/Urea as an Efficient Catalytic System for the One-Pot Synthesis of Highly Functionalized 1,4-Dihydropyridines and Polysubstituted 4H-Chromenes
Haleh Nouri Masoud MokhtaryOne-pot four-component synthesis of polyfunctionalized 1,4-dihydropyridine derivatives was developed by a condensation of aldehydes, malononitrile, diethylacetylenedicarboxylate and aniline in the presence of choline chloride/urea as a deep eutectic solvent (DES)at room أکثرOne-pot four-component synthesis of polyfunctionalized 1,4-dihydropyridine derivatives was developed by a condensation of aldehydes, malononitrile, diethylacetylenedicarboxylate and aniline in the presence of choline chloride/urea as a deep eutectic solvent (DES)at room temperature.Moreover, an efficient method was reported for the synthesis of highly substituted 4H-chromenes through one-pot, three-component reactions of cyclohexane-1,3-dione or dimedone, malononitrile and diethylacetylenedicarboxylate, in the presence of the deep eutectic solvent at 60 °C. This method develops by using an environmentally benign synthetic method along with the use of a costeffective catalyst. تفاصيل المقالة -
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10 - One-pot synthesis of 1,2,4,5-tetrasubstituted Imidazoles using BiFeO3
Roya Nazarpour Behnam AmiriThe BiFeO3 perovskite-type oxide was synthesized using the citrate gel method and the catalytic activity of the BiFeO3 was assessed in a multicomponent reaction of benzil, an aromatic aldehyde, and an amine in the presence of ammonium acetate under solvent-free conditio أکثرThe BiFeO3 perovskite-type oxide was synthesized using the citrate gel method and the catalytic activity of the BiFeO3 was assessed in a multicomponent reaction of benzil, an aromatic aldehyde, and an amine in the presence of ammonium acetate under solvent-free conditions. The physical and chemical properties of the catalyst were determined using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and Energy dispersive X-ray spectroscopy and Imidazole products were identified by comparing their melting points with already reported papers. SEM illustrated a smooth surface with a uniform morphology for the catalyst. Meanwhile, XRD indicates two phases of BiFeO3 and Bi2Fe4O9 at the same time. Moreover, IR and EDS both showed the absence of any impurities in the mentioned catalyst. The experimental data revealed excellent catalytic performance for BiFeO3 in absence of any solvents. Therefore, BiFeO3 can be used as an efficient and green catalyst for the synthesis of 1,2,4,5-tetrasubstituted Imidazoles. تفاصيل المقالة -
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11 - P2O5/Al2O3 as an effieientcatalystfor one-potsynthesis of polyhydroquinoline derivativesundersolvent-free conditions
Tayebeh Sanaeishoar Sara RoueenThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides sever أکثرThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including highyields, low reaction times, easy work up and little catalyst loading. تفاصيل المقالة -
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12 - Synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions via Phosphorus pentoxide supported on alumina (P2O5/Al2O3) catalyzed tandem reaction of Aldehyde with dimedone
Tayebeh Sanaeishoar Negar HormozinezhadPhosphorus pentoxide used on alumina (P2O5/Al2O3) as an inexpensive, eco-friendly and non-toxic acid catalyst for the one-pot synthesis of 1,8-dioxo-octahydroxanthenes via multi-component reactions under solvent-free conditions. The present approach offers several advan أکثرPhosphorus pentoxide used on alumina (P2O5/Al2O3) as an inexpensive, eco-friendly and non-toxic acid catalyst for the one-pot synthesis of 1,8-dioxo-octahydroxanthenes via multi-component reactions under solvent-free conditions. The present approach offers several advantages such as short reaction times, high yields, easy purification, recovery and reusability of the catalyst. تفاصيل المقالة -
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13 - P2O5/Al2O3 as an effieient catalyst for one-pot synthesis of polyhydroquinoline derivatives under solvent-free conditions
Tayebeh Sanaeishoar Sara RoueenThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides sever أکثرThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including high yields, low reaction times, easy work up and little catalyst loading. تفاصيل المقالة -
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14 - preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniIn this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly.In this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly. تفاصيل المقالة -
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15 - A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yieldsThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields تفاصيل المقالة -
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16 - A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniIn this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly.In this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly. تفاصيل المقالة -
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17 - One pot Solvent free Synthesis of Biginelli Type Derivatives using Ag2O/GO/TiO2 Composite Nanostructure and evaluation of biological activity
Fatemeh Samandizadeh Mohammad Mohammadi Ayeh Rayatzadeh Neda HasanzadehThe Biginelli Reaction is a one-pot acid catalysed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalised 3,4-dihydro-2(H)-pyrimidinones (DHPMs). This three-component reaction for the synthesis of dihydropyrimidinone أکثرThe Biginelli Reaction is a one-pot acid catalysed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalised 3,4-dihydro-2(H)-pyrimidinones (DHPMs). This three-component reaction for the synthesis of dihydropyrimidinone and corresponding dihydropyrimidinethiones has now been known for more than a century since first reported in 1893. The classical reaction has been modified in the recent past by using various catalysts and several structural variants in different solvents to synthesize large number of Biginelli type compounds. Also, these DHPMs (synthetic and natural) possess a wide range of pharmacological activities. تفاصيل المقالة -
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18 - Tungstophosphoric acid embedded magnetic chitosan as a green catalyst for the synthesis of N-cyclohexyl-3-aryl quinoxaline-2-amines
Ali Ayati Mansoureh Daraie Majid Heravi Bahareh TanhaeiIn the present study, a novel catalyst was well designed by incorporating the tungstophosphoric acid into the magnetic chitosan, as highly stable composite, in which the iron oxides were used the strong super-magnetic core. The prepared composite was characterized by se أکثرIn the present study, a novel catalyst was well designed by incorporating the tungstophosphoric acid into the magnetic chitosan, as highly stable composite, in which the iron oxides were used the strong super-magnetic core. The prepared composite was characterized by several methods, including FTIR, XRD, SEM, TEM and EDS and its catalytic activity was examined in a facile, green and highly efficient one-pot reaction for the synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amines with o-phenylenediamine, benzaldehyde and cyclohexyl isocyanide in water, under reflux conditions. This heterogeneous catalytic system was separated easily by an external magnet and was reused at least in four runs without pre-activation and appreciable loss in its activity. تفاصيل المقالة -
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19 - Nano-BF3/cellulose as a biodegradable novel catalyst for synthesis of highly functionalized tetrahydropyridines
Seyede Azita Fazeli-Attar Bi Bi Fatemeh MirjaliliNano-cellulose with high amount of free OH groups could be used as supporting agents for boron trifluoride (BF3). Nano-BF3/cellulose is a solid acid and a biodegradable catalyst which was prepared via reaction of nano-cellulose and BF3. The structure of this catalyst wa أکثرNano-cellulose with high amount of free OH groups could be used as supporting agents for boron trifluoride (BF3). Nano-BF3/cellulose is a solid acid and a biodegradable catalyst which was prepared via reaction of nano-cellulose and BF3. The structure of this catalyst was studied by FT-IR, FESEM, TEM, XRD, EDS, TGA, XRF and BET. In this research, the synthesis of highly functionalized tetrahydropyridines has been developed via a five-component reaction of aldehyde, amine and ethyl acetoacetate using nano-BF3/cellulose under solvent-free conditions. The structures of obtained products were identified by FTIR, 1H NMR and 13C NMR. Some advantages of this protocol are high to good yields, environmentally benign procedure, easy work-up of reaction and moderate reusability of the catalyst. تفاصيل المقالة -
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20 - Nano-SiO2/hexamethylenetetramine promoted synthesis of pyrano[2,3-c] pyrazoles under solvent-free conditions
Bi Bi Fatemeh Mirjalili Mina KeihanfarIn this study, the nano-SiO2/hexamethylenetetramine as a new basic heterogeneous nanocatalyst was prepared and used for the synthesis of pyranopyrazole via the four-component reaction. Various aldehydes, hydrazine hydrate, ethyl acetoacetate and malononitrile were react أکثرIn this study, the nano-SiO2/hexamethylenetetramine as a new basic heterogeneous nanocatalyst was prepared and used for the synthesis of pyranopyrazole via the four-component reaction. Various aldehydes, hydrazine hydrate, ethyl acetoacetate and malononitrile were reacted at room temperature under solvent-free and grinding conditions. The morphology and structure of nano-catalyst were investigated by techniques such as FT-IR spectroscopy, FESEM, TEM, XRD, CHNS elemental analyzer and TGA. The structure of pyranopyrazoles was determined by spectroscopic data of FTIR and NMR. The principal affairs of this procedure are easy work-up, high yields, mild conditions and short reaction times. تفاصيل المقالة -
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21 - Eggshell: A green and efficient heterogeneous catalyst for the synthesis of pyrano[3,2-c]quinoline
Leila Youseftabar-Miri Fatemeh Akbari Farshid GhraghsaharEggshell was found to be a versatile heterogeneous catalyst for the synthesis of pyrano[3,2-c]quinoline derivatives in good yields. This protocol has the advantages of environmental friendliness, short reaction time, low cost and convenient operation.Eggshell was found to be a versatile heterogeneous catalyst for the synthesis of pyrano[3,2-c]quinoline derivatives in good yields. This protocol has the advantages of environmental friendliness, short reaction time, low cost and convenient operation. تفاصيل المقالة -
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22 - L-proline: An efficient catalyst for the synthesis of quinoline derivatives in aqueous media
Elham Davoodi Leila Youseftabar-Miri Hamideh Hosseinjani-PirdehiAn efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. The procedure employs a three-component condensation reaction in one-pot using 2H-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence أکثرAn efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. The procedure employs a three-component condensation reaction in one-pot using 2H-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence of catalytic amount of L-prolinein aqueous media. تفاصيل المقالة -
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23 - Multicomponent Reactions Synthesis of Triaryl-1H Imidazoles Using Reductive-oxidative Reactions by MnO2-FeSO4 as a Catalyst
Ali A.Raheem Ali T.SalehThe study's chief purpose is to investigate multicomponent reactions synthesis of triaryl-1h imidazoles using reductive-oxidative reactions by MnO2 - FeSO4 as a catalyst.Some novel substituted imidazoles have been synthesized using MCRs, one-pot synthesis, and MnO2/FeSO أکثرThe study's chief purpose is to investigate multicomponent reactions synthesis of triaryl-1h imidazoles using reductive-oxidative reactions by MnO2 - FeSO4 as a catalyst.Some novel substituted imidazoles have been synthesized using MCRs, one-pot synthesis, and MnO2/FeSO4 as a catalyst; the method involves the reaction of benzil, aromatic aldehyde, and ammonium acetate in the presence of MnO2/FeSO4 as a reductive-oxidative catalyst under mild conditions. the obtained compounds were nontoxic, excellent yields, and environmentally friendly. The compounds were elucidated using IR and 1H-NMR spectra. To satisfy the aim of the study, Reactions have been performed simply by mixing 1,2-diketone with an aldehyde and ammonium acetate in the presence of the catalytic reagent of MnO2/FeSO4. The mixture was prepared by ground them together in a mortar with a pestle at room temperature for several minutes; after that, they purified by column chromatography, 2,4,5-triaryl substituted imidazole derivatives were obtained in excellent yields. تفاصيل المقالة