فهرس المقالات KRAS

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  1 - Fixed point theorem for non-self mappings and its applications in the modular ‎space
  R. Moradi A. ‎Razani
  ‎In this paper, based on [A. Razani, V. Rako$\check{c}$evi$\acute{c}$ and Z. Goodarzi, Nonself mappings in modular spaces and common fixed point theorems, Cent. Eur. J. Math. 2 (2010) 357-366.] a fixed point theorem for non-self contraction mapping $T$ in the modula أکثر

  ‎In this paper, based on [A. Razani, V. Rako$\check{c}$evi$\acute{c}$ and Z. Goodarzi, Nonself mappings in modular spaces and common fixed point theorems, Cent. Eur. J. Math. 2 (2010) 357-366.] a fixed point theorem for non-self contraction mapping $T$ in the modular space $X_\rho$ is presented. Moreover, we study a new version of Krasnoseleskii's fixed point theorem for $S+T$, where $T$ is a continuous non-self contraction mapping and $S$ is continuous mapping such that $S(C)$ resides in a compact subset of $X_\rho$, where $C$ is a nonempty and complete subset of $X_\rho$, also $C$ is not bounded. Our result extends and improves the result announced by Hajji and Hanebally [A. Hajji and E. Hanebaly, Fixed point theorem and its application to perturbed integral equations in modular function spaces, Electron. J. Differ. Equ. 2005 (2005) 1-11]. As an application, the existence of a solution of a nonlinear integral equation on $C(I, L^\varphi) $ is presented, where $C(I, L^\varphi)$ denotes the space of all continuous function from $I$ to $L^\varphi$, $L^\varphi$ is the Musielak-Orlicz space and $I=[0,b] \subset \mathbb{R}$. In addition, the concept of quasi contraction non-self mapping in modular space is introduced. Then the existence of a fixed point of these kinds of mapping without $\Delta_2$-condition is proved. Finally, a three step iterative sequence for non-self mapping is introduced and the strong convergence of this iterative sequence is studied. Our theorem improves and generalized recent know results in the ‎literature.‎ تفاصيل المقالة
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  2 - Positive solution for boundary value problem of fractional dierential equation
  Haidong Qu
  In this paper, we prove the existence of the solution for boundary value prob-lem(BVP) of fractional dierential equations of order q 2 (2; 3]. The Kras-noselskii's xed point theorem is applied to establish the results. In addition,we give an detailed example to demons أکثر

  In this paper, we prove the existence of the solution for boundary value prob-lem(BVP) of fractional dierential equations of order q 2 (2; 3]. The Kras-noselskii's xed point theorem is applied to establish the results. In addition,we give an detailed example to demonstrate the main result. تفاصيل المقالة
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  3 - Positive Solution for Boundary Value Problem of Fractional Dierential Equation
  H. Qu
  In this paper, we prove the existence of the solution for boundary value prob-lem(BVP) of fractional dierential equations of order q 2 (2; 3]. The Kras-noselskii's xed point theorem is applied to establish the results. In addition,we give an detailed example to demons أکثر

  In this paper, we prove the existence of the solution for boundary value prob-lem(BVP) of fractional dierential equations of order q 2 (2; 3]. The Kras-noselskii's xed point theorem is applied to establish the results. In addition,we give an detailed example to demonstrate the main result. تفاصيل المقالة
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  4 - استخراج و شناسایی یک فلاون برای نخستین بار از عصارۀ گیاه Artemisia turanica Krasch. جمع‌آوری شده از اسفراین در استان خراسان
  سارا صفری محبوبه طاهرخانی
  تاکنون ترکیبات طبیعی متنوعی نظیر مونوترپن ، سزکوئی ترپن ، ترکیبات فلاونوئیدی و غیره با خواص بیولوژیکی و دارویی از جنس Artemisia استخراج و شناسایی شده است. با توجه به اهمیت و ارزش دارویی این جنس، هدف از این تحقیق بررسی فیتوشیمیایی درمنه قرمز (Artemisia turanica Krasch) أکثر

  تاکنون ترکیبات طبیعی متنوعی نظیر مونوترپن ، سزکوئی ترپن ، ترکیبات فلاونوئیدی و غیره با خواص بیولوژیکی و دارویی از جنس Artemisia استخراج و شناسایی شده است. با توجه به اهمیت و ارزش دارویی این جنس، هدف از این تحقیق بررسی فیتوشیمیایی درمنه قرمز (Artemisia turanica Krasch) از نقطه نظر ترکیبات طبیعی موجود در عصاره می باشد. برای انجام این تحقیق، اندام هوایی گیاه مذکور در مرحلۀ گلدهی در سال 1393 از روستای بام بعد از قهرمان آباد در اسفراین جمع‌آوری و به روش خیساندن عصاره گیری شد. سپس جهت جداسازی هیدروکربن ها با زنجیره های بلند، عمل چربی‌گیری صورت گرفت. به منظور آنالیز و جداسازی فراکسیون های مختلف، عصاره بر روی ستون کروماتوگرافی برده شد. تمامی فراکسیون های حاصل از لحاظ وجود ترکیبات طبیعی توسط تکنیک TLC مورد بررسی قرار گرفتند و در نهایت ترکیب طبیعی با استفاده از تکنیک های طیف سنجی IR، 13C-NMR و 1H-NMR شناسایی شد. نتایج حاصل از تکنیک‌های طیف سنجی منجر به شناسایی یک فلاون به نام 3،5،́3 و ́4- تترا هیدروکسی، 7و́5- متوکسی فلاون، برای اولین بار در عصارۀ این گیاه شد. لذا با توجه به وجود فلاونوئید در عصاره این گیاه، پیش‌بینی می گردد که این گیاه دارای اثرات آنتی اکسیدانی بالایی باشد. تفاصيل المقالة
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  5 - Apoptosis induced by Zizyphus jujuba seed essential oil in colorectal cancer cells line HT-29
  زهرا زمانی الهام قدوسی دهنوی رضا حاجی حسینی محمد ارجمند سیما نصری
  10.30495/medherb.2021.686381
  Background & Aim: In traditional medicine, Zizyphus jujuba (jujube) has been used due to its medicinal properties and various physiological functions such as antioxidant, anticancer and anti-inflammatory properties. This study was conducted to study anti-cancer and أکثر

  Background & Aim: In traditional medicine, Zizyphus jujuba (jujube) has been used due to its medicinal properties and various physiological functions such as antioxidant, anticancer and anti-inflammatory properties. This study was conducted to study anti-cancer and apoptotic effects of essential oil from Zizyphus jujuba seeds and to evaluate the effect of essential oils on p53, APC and KRAS genes expression in HT-29 colorectal cell line.Experimental: In this study, the essential oil of jujube seeds collected from orchards in Isfahan was prepared by Clevenger apparatus and then analyzed by GC-MS. The effects of toxicity and cell viability were determined using Trypan Blue, MTT and clonogenic methods. DNA fragmentation and apoptosis techniques were used to evaluate the mechanism of the effects of essential oil on cell death by flow cytometry. Finally, Real-time PCR was used to evaluate the expression of p53, APC and KRAS genes and their role in induction of apoptosis.Results: Essential oil of Zizyphus jujuba seeds reduced the viability of cells by concentration and time-dependent manner as compared to the control group. The essential oil also induced apoptosis by increasing gene expression p53 and suppressing gene expression KRAS.Recommended applications/industries: The present results indicated that essential oil of Zizyphus jujuba seeds induces apoptosis by targeting genes involved in colon carcinogenesis. However, further investigations on signaling pathways are needed to fully confirm the results of this study. تفاصيل المقالة
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  6 - Effect of Spirulina platensis on the immunological and hematological factors in comparison with levamisole in Persian shepherd dogs
  سام ترکان محمد جواد عکاشه
  10.30495/medherb.2021.686382
  Background & Aim: Spirulina microalgae is known to has beneficial effects in the treatment of many animals diseases. Effects of Spirulina platensis microalgae, singly or in comparison with levamisole drug are not still studied in dogs. Thus, the present study was co أکثر

  Background & Aim: Spirulina microalgae is known to has beneficial effects in the treatment of many animals diseases. Effects of Spirulina platensis microalgae, singly or in comparison with levamisole drug are not still studied in dogs. Thus, the present study was conducted to investigate the effects of this microalgae on hematological and immunological parameters in dogs.Experimental: In this research, 24 native breed dogs were used for 30 days. The dogs were divided into three groups of eight randomly, including a control group, treatment group (received 2 g Spirulina orally) and the third group received 5 mg/kg Levamisole. At the end of mentioned period, hematocrit percent, Hb, RBC, WBC, Neutrophil, Lymphocyte, Eosinophil, monocyte, basophil levels and immunological factors including IgM, total protein and phagocytic precent were measured.Results: Hematocrit in levamisole receiving group increased significantly (P<0.05). Results showed that RBC and Hb levels in Spirulina receiving group were significantly higher than the control and levamisole groups. Alb and Neutrophil levels in Spirulina receiving group were lower than the other two groups. In addition, Eosinophil and WBC levels in control group were significantly lower than the other two groups, but monocyte and Lymphocyte levels in control group increased significantly (P<0.001). Also, on the 30th day, total protein and phagocytic percent in Spirulina receiving group were significantly higher than others groups. In addition, in Spirulina and levamisole groups a significant increase in IgM level was observed (P<0.001).Recommended applications/industries: It can be concluded that the use of Spirulina in dogs for a short time could improve hematological and immunological factors and the effects of Spirulina alga in the most factors is comparable to levamisole drug. تفاصيل المقالة
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  7 - Vitexin modifying the expression of APC, p53, KRAS genes with metabolome profile changes in HT-29 colorectal cancer cell line
  الهام قدوسی دهنوی رضا حاجی حسینی محمد ارجمند سیما نصری زهرا زمانی
  10.30495/medherb.2023.703711
  Background & Aim: Colorectal canceris a clinically heterogeneous disease resulting from metabolome pattern alterations of many metabolites and their genetic factor interactions in man. Chemotherapy in colorectal cancer is generally followed by multiple side effects, أکثر

  Background & Aim: Colorectal canceris a clinically heterogeneous disease resulting from metabolome pattern alterations of many metabolites and their genetic factor interactions in man. Chemotherapy in colorectal cancer is generally followed by multiple side effects, including drug resistance; It is well established that herbal medicines are gaining worldwide interest in treating many cancers. Vitexin is an apigenin flavone glycoside present in hawthorn has exhibited therapeutic properties. This study was performed to assess the antitumor properties of Vitexin on the expression of p53, KRAS, and APC genes and the metabolome profile alterations associated with these genetic modifications.Experimental: Cells were treated with different concentrations of Vitexin, and toxicity and cell growth inhibition were ascertained in vitro using the MTT assay method. Cells were treated with Vitexin, and gene expression was determined. Following metabolome 1HNMR spectroscopy with 1D NOESY protocol and the resulting spectra scrutinized to classify differentiated metabolites and their biochemical pathways. Integrative systems biology analysis software examined the metabolites and the genes, and the main pathways modulated by gene expression were identified.Results: Our finding revealed that a 50% inhibitory concentration for Vitexin was 16.32 μM, while the relative expression of tumor suppressor genes APC and p53 in treated cells enhanced and the expression of the KRAS oncogene gene decreased significantly compared to the control group. The crucial changes in convergent metabolic phenotype with genes were identified in this investigation.Recommended applications/industries: Our findings revealed that Vitexin exhibits antitumor properties by targeting a specific biochemical pathway in the cell's metabolome profile due to changes in genes involved in colon cancer. تفاصيل المقالة