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حرية الوصول المقاله
1 - A Green and Efficient One-pot Synthesis of Propanamides by a Three-component Reaction of 2-(2-oxopropyl) isoindoline-1,3-dione, Alkyl isocyanide and an E-cinnamic acid under Catalyst-free Conditions in Water
Ali Ramazani Ali Jafari Sang Woo Joo Yavar Ahmadi Fariba Sadri Pegah Azimzadeh AsiabiA green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in w أکثرA green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side product and the products were obtained without any purification. The structures of the products were deduced from their 1 H NMR, 13C NMR and IR spectra. The present methodology offers several advantages such as a simple procedure, catalyst-free, mild reaction conditions, high yields, and the absence of any volatile and hazardous organic solvents. تفاصيل المقالة -
حرية الوصول المقاله
2 - Condensationtion of 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes
Mahsa Mahpeyma Bita MohtatThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields.The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields. تفاصيل المقالة -
حرية الوصول المقاله
3 - Reaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes
Mahsa Mahpeyma Bita MohtatThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yieldsThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields تفاصيل المقالة -
حرية الوصول المقاله
4 - Reaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes
Mahsa Mahpeyma Bita MohtatThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields.The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields. تفاصيل المقالة -
حرية الوصول المقاله
5 - Mechanistic Investigation of the [1+4] Cycloaddition Reaction Between Alkyl Isocyanides and 3-benzylidene-2,4-pentanedione: A Theoretical Study
Mohammad Zakarianezhad Batoul Makiabadi Atefeh AbbaslouThe stepwise reaction mechanism of the [1+4] cycloaddition reaction between alkyl isocyanides (contains methyl benzene isocyanide, tert-butyl isocyanide, cyclohexyl isocyanide) with 3-Benzylidene-2,4-pentanedione both in the gas phase and in solvent was studied theoreti أکثرThe stepwise reaction mechanism of the [1+4] cycloaddition reaction between alkyl isocyanides (contains methyl benzene isocyanide, tert-butyl isocyanide, cyclohexyl isocyanide) with 3-Benzylidene-2,4-pentanedione both in the gas phase and in solvent was studied theoretically with B3LYP method using 6-311++G(d,p) basis set. The potential energy of all structures participated in the reaction path has been evaluated. The quantum mechanical calculation was performed to gain a better understanding of the most important geometrical parameters, determine the solvent effect, and the effect of different substituted groups on the potential energy surfaces. Unexpectedly, the second step of all reactions was recognized as the rate-determining step. The best product configuration was recognized based upon the quantum mechanical calculations. The natural bond orbital method (NBO) applied for a better understanding of molecular interaction. The final rate equation shows that the overal reaction rate is second order which depends on the R1 and R2 concentration. The order of reaction with respect to each reactant is one. تفاصيل المقالة