Herbal cosmeceuticals: New opportunities in cosmetology
Subject Areas : Flavor, Perfumes and Cosmetics
Mohd Aqil
1
,
Aiswarya Chaudhuri
2
,
Abdul Qadir
3
1 - Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062 India
2 - Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062 India
3 - Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062 India
Keywords: phytochemicals, Patents, phytotoxicity, nanotechnology, Pharmacological uses, Cosmeceuticals,
Abstract :
Cosmeceuticals are defined as cosmetic products designed to improve and enhance the physical appearance, beauty, health as well as to treat the skin ailments. The main objective of the present review is to document various plants along with their active phytochemicals like alkaloids, flavonoids, saponins, sterols, triterpenes, tannins, etc. responsible for activities like antioxidant, anti-inflammatory, sunlight protection, skin regeneration, de-pigmentation, anti-dandruff, anti-hair fall, anti-lice, etc. This study also provides an overview of geographical distribution, environmental attributes, extraction and isolation procedure of active phytochemicals responsible for biological activity. This review further tries to assess the regulatory scenario of cosmeceuticals as they are placed under the subclass of cosmetics under Europe and Japan regulations , whereas in US regulations, cosmeceuticals are placed under the subclass of drugs. The application of nanotechnology in formulating cosmeceuticals (nano-cosmeceuticals) has also seen the light of the day. It can be viewed as a “new paradigm” in the cosmetic industry.
Adewole, E., Talabi, J.Y., 2015. Estimation of percentage of ascorbic acid contents in selected trophical fruits. Ann. Biol. Sci. 3, 5-7.
Afaq, F., Mukhtar, H., 2006. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp. Dermatol. 15(9), 678-684.
Aloqbi, A., Omar, U., Yousr, M., Grace, M., Lila, M.A., Howell, N., 2016. Antioxidant activity of pomegranate juice and Punicalagin. Nat. Sci. 8, 235-246.
Anitha, T., 2012. Medicinal plants used in skin protection. Asian J. Pharm. Clin. Res. 5(3), 35-38.
Ao, M., Shi, Y., Cui, Y., Guo, W., Wang, J., Yu, L., 2010. Factors influencing glabridin stability. Nat. Prod. Commun. 5(12), 1907-1912.
Azab, A., Nassar, A., Azab, A.N., 2016. Anti-inflammatory activity of natural products. Molecules 21(10), 1321.
Bag, A., Bhattacharyya, S.K., Chattopadhyay, R.R., 2013. Therapeutic potential of Terminalia chebula Retz. (Combretaceae): The Ayurvedic wonder. Asian. Pac. J. Trop. Biomed. 3, 244-252.
Bellad, K.A., Nanjwade, B.K., Kamble, M.S., Srichana, T., Idris, N.F., 2017. Development ofcosmeceuticals. World. J. Pharm. Pharm. Sci. 6(4), 643-691.
Bergs, D., Merz, J., Delp, A., Joehnck, M., Martin, G., Schembecker, G., 2013. A standard procedure for the selection of solvents for natural plant extraction in the early stages of process development. Chem. Eng. Technol. 36(10), 1739-1748.
Bernardi, D.S., Pereira, T.A., Maciel, N.R., Bortoloto, J., Viera, G.S., Oliveira, G.C., Rocha-Filho, P.A., 2011. Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments. J. Nanobiotechnol. 9(1), 44.
Bhandari, S.R., Yoon, M.K., Kwak, J.H., 2014. Contents of phytochemical constituents and antioxidant activity of 19 garlic (Allium sativum L.) parental lines and cultivars. Hortic. Environ. Biote. 55(2), 138-147.
Bijak, M., 2017. Silybin, a major bioactive component of milk thistle (Silybum marianum L. Gaernt.)-Chemistry, bioavailability and metabolism. Molecules 22(11), 1942.
Bose, S., Laha, B., Banerjee, S., 2013. Anti-inflammatory activity of isolated allicin from garlic with post-acoustic waves and microwave radiation. J. Adv. Pharm. Educ. Res. 3(4), 512-515.
Bulduk, I., Sahin, M.D., Sanli, S., 2016. Arbutin analysis in leaves, fruit and branches of Pyrus anatolica, method optimization. Eurasian. J. Anal. Chem. 11, 233-244.
Butnariu, M.V., Giuchici, C.V., 2011. The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin's protective mechanisms against UVA radiation. J. Nanobiotechnol. 9(1), 3.
Camouse, M.M., Domingo, D.S., Swain, F.R., Conrad, E.P., Matsui, M.S., Maes, D., Declercq, L., Cooper, K.D., Stevens, S.R., Baron, E.D., 2009. Topical application of green and white tea extracts provides protection from solar‐simulated ultraviolet light in human skin. Exp. Dermatol. 18(6), 522-526.
Campa, M., Baron, E., 2018. Anti-aging effects of select Botanicals: scientific evidence and current trends. Cosmetics 5(3), 54.
Chakraborty, A., Sahoo, M., Roy, S.D., Dasgupta, R.K., 2018. Anti-ageing natural herbs: a systemic review. Ind. Res. J. Pharm. Sci. 5(3), 1589-1598.
Cho, S., Lee, S., Lee, M.J., Lee, D.H., Won, C.H., Kim, S.M., Chung, J.H., 2009. Dietary Aloe vera supplementation improves facial wrinkles and elasticity and it increases the type I procollagen gene expression in human skin in vivo. Ann. Dermatol. 21(1), 6-11.
Choi, S., Park, Y.I., Lee, S.K., Kim, J.E., Chung, M.H., 2002. Aloesin inhibits hyperpigmentation induced by UV radiation. Clin. Exp. Dermatol. 27(6), 513-515.
Da Costa, A.S., Arrigoni-Blank, M.D.F., Carvalho Filho, J.L.S.D., de Santana, A.D.D., Santos, D.D.A., Alves, P.B., Blank, A.F., 2015. Chemical diversity in basil (Ocimum sp.) germplasm. Sci. World J. 2015, 1-9.
David, N.B., 2005. Review of the regulation of products at the interface between cosmetics and therapeutic goods. Report prepared for the TGA. 1, 23-85.
Del Bano, M.J., Lorente, J., Castillo, J., Benavente-García, O., Del Rio, J.A., Ortuño, A., Quirin, K.W., Gerard, D., 2003. Phenolic diterpenes, flavones and rosmarinic acid distribution during the development of leaves, flowers, stems and roots of Rosmarinus officinalis. Antioxidant activity. J. Agric. Food Chem. 51(15), 4247-4253.
Del Castillo, M.D., Fernandez-Gomez, B., Martinez-Saez, N., Iriondo-DeHond, A., Martirosyan, D.M., Mesa, M.D., 2016. Coffee silverskin extract for aging and chronic diseases. Funct. Foods Chro. Dis.1, 386-409.
Devi, R., 2005. Cosmeceutical applications of aloe gel. Nat. Prod. Rad. 4(4), 322-327.
Di Campli, E., Di Bartolomeo, S., Pizzi, P.D., Di Giulio, M., Grande, R., Nostro, A., Cellini, L., 2012. Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs. Parasitol. Res. 111(5), 1985-1992.
Duarah, S.A.N.J.U.K.T.A., Pujari, K.U.N.A.L., Durai, R.D., Narayanan, V.H.B., 2016. Nanotechnologybased cosmeceuticals: a review. Int. J. Appl. Pharm. 8, 8-12.
Dureja, H., Kaushik, D., Gupta, M., Kumar, V., Lather, V., 2005. Cosmeceuticals: An emerging concept. Indian J. Pharmacol. 37(3), 155.
Elteraifi, I.E., Hassanali, A., 2011. Oil and Azadirachtin contents of neem (Azadirachta indica A. Juss) seed kernels collected from trees growing in different habitats in Sudan. Int. J. Biol. Chem. Sci. 5(3), 1063-1072.
Ganesan, P., Choi, D.K., 2016. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy. Int. J. Nanomedicine 11, 1987.
Gattuso, G., Barreca, D., Gargiulli, C., Leuzzi, U., Caristi, C., 2007. Flavonoid composition of citrus juices. Molecules 12, 1641-1673.
George, P., 2011. Concerns regarding the safety and toxicity of medicinal plants-An overview. J. Appl. Pharm. Sci. 1(6), 40-44.
Hammer, K.A., Carson, C.F., Riley, T.V., 2004. Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae. J. Antimicrob. Chemoth. 53(6), 1081-1085.
Hui, L., 2013. ‘Aloe Vera Review’, Iarc Monographs, 1999, 37-71.
Hwang, S.L., Kim, J.C., 2008. In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly (ε-caprolacton) nanocapsules. J. Microencapsul. 25(5), 351-356.
Jager, S., Trojan, H., Kopp, T., Laszczyk, M.N., Scheffler, A., 2009. Pentacyclic triterpene distribution in various plants-rich sources for a new group of multi-potent plant extracts. Molecules 14(6), 2016-2031.
Jamshidi-Kia, F., Lorigooini, Z., Amini-Khoei, H., 2018. Medicinal plants: Past history and future perspective. J. HerbMed. Pharmacol. 7(1).
Jeszka-Skowron, M., Sentkowska, A., Pyrzyńska, K., De Peña, M.P., 2016. Chlorogenic acids, caffeine content and antioxidant properties of green coffee extracts: influence of green coffee bean preparation. Eur. Food. Res. Technol. 242(8), 1403-1409.
Kaladhar, D.S.V.G.K., Geetha, S.M., Varahalarao, V., Nagendra, S.Y., 2013. Anti-dandruff activity of ethanolic extract of Sapindus mukorossi seed coat and Ficus racemosa fruit peel and in silico protein interaction studies. Int. J. Appl. Pharm. Biol. Res. 2(3), 149-155.
Kanlayavattanakul, M., Lourith, N., 2018. Skin hyperpigmentation treatment using herbs: A review of clinical evidences. J. Cosmet. Laser. Ther. 20(2), 123-131.
Kaul, S., Gulati, N., Verma, D., Mukherjee, S., Nagaich, U., 2018. Role of nanotechnology in cosmeceuticals: a review of recent advances. J. Pharm. 2018, 1-19.
Kaur, I.P., Agrawal, R., 2008. Nanotechnology: a new paradigm in cosmeceuticals. Recent. Pat. Drug. Deliv. Formul. 1(2), 171-182.
Kaushik, R., Gupta, D., Yadav, R., 2011. Alopecia: herbal remedies. Int. J. Pharm. Sci. Res. 2(7), 1631.
Khan, S., Tosun, A., Kim, Y.S., 2015. Ginsenosides as Food Supplements and Their Potential Role in Immunological and Neurodegenerative Disorders. In Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease (303-309). Academic Press.
Kidd, P.M., 2009. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea and grape seed extracts. Altern. Med. Rev. 14(3), 226-46.
Kintzios, S., Makri, O., Panagiotopoulos, E., Scapeti, M., 2003. In vitro rosmarinic acid accumulation in sweet basil (Ocimum basilicum L.). Biotechnol. Lett. 25(5), 405-408.
Krishna, A.G., Gaurav, R., Singh, B.A., Kumar, P.P., Preeti, C., 2010. Coconut oil: chemistry, production and its applications-a review. Ind. Coconut. J. 53(3), 15-27.
Kshirsagar, A., Ingawale, D., Ashok, P., Vyawahare, N., 2009. Silymarin: A comprehensive review. Pharmacogn. Rev. 3(5), 126.
Kulkarni, S.S., Bhalke, R.D., Pande, V.V., Kendre, P.N., 2014. Herbal plants in photo protection and sun screening action: An overview. Indo. Am. J. Pharm. 4(2), 1104-1113.
Kumar, N., Pruthi, V., 2014. Potential applications of ferulic acid from natural sources. Biotechnol. Rep. 4, 86-93.
Kumar, N., Tharatha, S., Chaiyasut, C., 2011. Development and validation of simple isocratic high performance liquid chromatography-ultraviolet (HPLC-UV) method for determination of safflower yellow in Carthamus tinctorius L.-loaded nanostructured lipid carriers (NLC). Afr. J. Pharm. Pharmacol. 5(20), 2335-2341.
Kumar, R., 2017. Botanical Cosmeceuticals for skin care. Int. J. Pharm. Biol. Arch. 8(4), 34-39.
Kwak, J.H., Seo, J.M., Kim, N.H., Arasu, M.V., Kim, S., Yoon, M.K., Kim, S.J., 2017. Variation of quercetin glycoside derivatives in three onion (Allium cepa L.) varieties. Saudi J. Biol. Sci. 24(6), 1387-1391.
Lacatusu, I., Badea, N., Murariu, A., Nichita, C., Bojin, D., Meghea, A., 2010. Antioxidant capacity of lipid nanoparticles loaded with rosemary extract. Mol. Cryst. Liq. Cryst. 523(1), 260-832.
Lee, J., Jung, E., Lee, J., Huh, S., Kim, J., Park, M., So, J., Ham, Y., Jung, K., Hyun, C.G., Kim, Y.S., 2007. Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. J. Ethnopharmacol. 109(1), 29-34.
Lee, S.H., Choi, S.Y., Kim, H., Hwang, J.S., Lee, B.G., Gao, J.J., Kim, S.Y., 2002. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol. Pharm. Bull. 25(8), 1045-1048.
Lu, W.C., Chiang, B.H., Huang, D.W., Li, P.H., 2014. Skin permeation of D-limonene-based nanoemulsions as a transdermal carrier prepared by ultrasonic emulsification. Ultrason. Sonochem. 21(2), 826-832.
Mao, Q.Q., Xu, X.Y., Cao, S.Y., Gan, R.Y., Corke, H., Li, H.B., 2019. Bioactive compounds and bioactivities of ginger (Zingiber officinale roscoe). Foods 8(6), 185.
Marwat, S.K., Khan, M.S., Ghulam, S., Anwar, N., Mustafa, G., Usman, K., 2011. Phytochemical constituents and pharmacological activities of sweet Basil-Ocimum basilicum L.(Lamiaceae). Asian J. Chem. 23(9), 3773.
Meer, S., Akhtar, N., Mahmood, T., Igielska-Kalwat, J., 2017. Efficacy of Phoenix dactylifera L.(Date Palm) creams on healthy skin. Cosmetics 4(2), 13.
Mishra, A.K., Mishra, A., Chattopadhyay, P., 2011. Herbal cosmeceuticals for photoprotection from ultraviolet B radiation: A review. Trop. J. Pharm. Res. 10(3), 351-360.
Mishra, V.K., Mishra, N., 2016. Concept of cosmeceuticals in Ayurveda for skin, beauty & body care. World. J. Pharm. Pharm. Sci. 6, 486-493.
Mohammadhosseini, M., 2017. The ethnobotanical, phytochemical and pharmacological properties and medicinal applications of essential oils and extracts of different Ziziphora species. Ind. Crop Prod. 105, 164-192.
Mohammadhosseini, M., Sarker, S.D., Akbarzadeh, A., 2017. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J. Ethnopharmacol. 199, 257-315.
Mphahlele, R.R., Fawole, O.A., Makunga, N.P., Opara, U.L., 2016. Effect of drying on the bioactive compounds, antioxidant, antibacterial and antityrosinase activities of pomegranate peel. BMC Complement. Altern. Med. 16(1), 143.
Musdja, M.Y., Rahman, H.A., Hasan, D., 2018. Antioxidant activity of catechins isolate of uncaria gambier roxb in male rats. LIFE: Int. J. Health Life Sci. 4(2), 34-46.
Muthukumaran, S., Tranchant, C., Shi, J., Ye, X., Xue, S.J., 2017. Ellagic acid in strawberry (Fragaria spp.): Biological, technological, stability and human health aspects. J. Food. Saf. 1(4), 227-252.
Narayanan, C.R., Natu, A.A., 1974. Triterpene acids of Indian clove buds. Phytochemistry 13 (9), 1999-2000.
Ngo, T.V., Scarlett, C.J., Bowyer, M.C., Ngo, P.D., Vuong, Q.V., 2017. Impact of different extraction solvents on bioactive compounds and antioxidant capacity from the root of Salacia chinensis L. J. Food Qual. 2017, 1-8.
Niculae, G., Lacatusu, I., Badea, N., Stan, R., Vasile, B.S., Meghea, A., 2014. Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations. Photochem. Photobiol. Sci. 13(4), 703-716.
Noumi, E., Snoussi, M., Hajlaoui, H., Trabelsi, N., Ksouri, R., Valentin, E., Bakhrouf, A., 2011. Chemical composition, antioxidant and antifungal potential of Melaleuca alternifolia (tea tree) and Eucalyptus globulus essential oils against oral Candida species. J. Med. Plant Res. 5(17), 4147-4156.
Nwiloh, B.I., Uwakwe, A.A., Akaninwor, J.O., 2016. Phytochemical screening and GC-FID analysis of ethanolic extract of root bark of Salacia nitida L. Benth. J. Med. Plants Stud. 4(6), 283-287.
Ong, E.S., 2004. Extraction methods and chemical standardization of botanicals and herbal preparations. J. Chromatogr. B 812(1-2), 23-33.
Pal, R.S., Pal, Y., Rai, A.K., Wal, P., Wal, A., 2018. Synthesis and evaluation of herbal based hair dye. Open. Dermatol. J. 12(1), 90-98.
Patel, M., Naik, S.N., 2004. Gamma-oryzanol from rice bran oil-A review. J. Sci. Ind. Res. 63, 569-578.
Penugonda, K., Lindshield, B.L., 2013. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nut 5(9), 3617-3633.
Pereira, F., Baptista, R., Ladeiras, D., Madureira, A.M., Teixeira, G., Rosado, C., Fernandes, A.S., Ascensão, L., Silva, C.O., Reis, C.P., Rijo, P., 2015. Production and characterization of nanoparticles containing methanol extracts of Portuguese lavenders. J. Meas. 74, 170-177.
Poomanee, W., Chaiyana, W., Wickett, R.R., Leelapornpisid, P., 2017. Stability and solubility improvement of Sompoi (Acacia concinna Linn.) pod extract by topical microemulsion. Asian J. Pharm. Sci. 12(4), 386-393.
Potluri, A., Shaheda, S.K., Rallapally, N., Durrivel, S., Harish, G., 2013. A review on herbs used in anti-dandruff shampoo and its evaluation parameters. J. Topical Cosmetic Sci. 4(1), 5-13.
Prashant, D.K., Sandip, M.H., 2017. Neem (Azadirachta indica), Reetha (Sapindus mukorossi), Shikakai (Acacia concinna), Hibiscus flower (Hibiscus sabdariffa) oil and Lemon: A natural antidandruff formula. Int. J. Agric. Sci. Res. 2(3), 27-29.
Pritwani, R., Mathur, P., 2017. β-Carotene content of some commonly consumed vegetables and fruits available in Delhi, India. J. Nutr. Food. Sci. 7(625), 1-2.
Pushpakumari, K.N., Varghese, N., Kottol, K., 2015. Enhancing the absorption of curcuminoids from formulated turmeric extracts. Int. J. Pharm. Sci. Res. 6(6), 2468.
Rahaiee, S., Moini, S., Hashemi, M., Shojaosadati, S.A., 2015. Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review. J. Food. Sci. Tech. 52(4), 1881-1888.
Rahman, M.S., 2007. Allicin and other functional active components in garlic: health benefits and bioavailability. Int. J. Food Prop. 10(2), 245-268.
Raj, R.K., Chandrul, K.K., 2016. Regulatory requirements for cosmetics in relation with regulatory authorities in India against US, Europe, Australia and Asean countries. Int. J. Pharma. Res. Health. Sci. 4(5), 1332-1341.
Rath, S., Olempska-Beer, Z., Kuznesof, P.M., 2009. Lycopene extract from tomato. Chemical and Technical Assessment (CTA). Lycored Natural Products Industries Ltd, 1-9.
Rezaee, R., Hosseinzadeh, H., 2013. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran. J. Basic. Med. Sci. 16(1), 12.
Sabale, P., Modi, A., Sabale, V., 2013. Curcuma longa Linn. A phytochemical and phytopharmacological review. J. Pharmacogn. Phytochem. 5(2), 59-68.
Sahatpure, N.S., Hills, S., 2018. Anti-ageing herbs-a review. Int. J. Sci. Res. 3, 51-61.
Sasidharan, S., Chen, Y., Saravanan, D., Sundram, K.M., Latha, L.Y., 2011. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr. J. Tradit. Complement. Altern. Med. 8(1):1-10.
Setyowati, H., 2017. Gambir (Uncaria gambir Roxb.) as natural cosmeceutical agent. CDK, 250(44), 1-3.
Shekarchi, M., Hajimehdipoor, H., Saeidnia, S., Gohari, A.R., Hamedani, M.P., 2012. Comparative study of rosmarinic acid content in some plants of Labiatae family. Pharmacogn. Mag. 8(29), 37.
Shimogaki, H., Tanaka, Y., Tamai, H., Masuda, M., 2000. In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition. Int. J. Cosmet. Sci. 22(4), 291-303.
Silver, K.S., Du, Y., Nomura, Y., Oliveira, E.E., Salgado, V.L., Zhorov, B.S., Dong, K., 2014. Voltage-gated sodium channels as insecticide targets. Adv. Insect. Physiol. 46, 389-433.
Soonwera, M., Wongnet, O., Sittichok, S., 2018. Ovicidal effect of essential oils from Zingiberaceae plants and Eucalytus globulus on eggs of head lice, Pediculus humanus capitis De Geer. Phytomedicine 47, 93-104.
Sumit, K., Vivek, S., Sujata, S., Ashish, B., 2012. Herbal cosmetics: used for skin and hair. Inven. J. 2012, 1-7.
Takahashi, M., Kitamoto, D., Asikin, Y., Takara, K., Wada, K., 2009. Liposomes encapsulating Aloe vera leaf gel extract significantly enhance proliferation and collagen synthesis in human skin cell lines. J. Oleo Sci. 58(12), 643-650.
Taofiq, O., González-Paramás, A.M., Martins, A., Barreiro, M.F., Ferreira, I.C., 2016. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-A review. Ind. Crop Prod. 90, 38-48.
Teng, H., Seuseu, K.T., Lee, W.Y., Chen, L., 2019. Comparing the effects of microwave radiation on 6-gingerol and 6-shogaol from ginger rhizomes (Zingiber officinale Rosc). PloS One. 14(6).1-16.
Thakur, A., 2011. Juglone: a therapeutic phytochemical from Juglans regia L. J. Med. Plants. Res. 5, 5324-5330.
Thornfeldt, C., 2005. Cosmeceuticals containing herbs: fact, fiction and future. Dermatol. Surg. 31, 873-881.
Tovar, R.T., Petzel, R.M., 2009. Herbal toxicity. Disease-a-month: DM, 55(10), 592.
Tripathy, S. Dhull, K., Dureja, H., 2015. Cosmetics: Regulatory Scenario in USA, EU and India. J. Pharm. Technol. Res. Manag. 3(2), 127-139.
Ujvary, I., 2010. Pest Control Agents from Natural Products. In Hayes' Handbook of Pesticide Toxicology (119-229), Academic Press.
Upadhyay, A., Singh, D.K., 2012. Efeitos farmacológicos do Sapindus mukorossi. Rev. Inst. Med. Trop. Sp. 54(5), 273-280.
Venditti, A., Frezza, C., Serafini, I., Pulone, S., Scardelletti, G., Sciubba, F., Bianco, A., Serafini, M., 2018. Chemical profiling of the fruits of Styrax officinalis L. from Monti Lucretili (Latium region, Central Italy): Chemotaxonomy and nutraceutical potential. Trends Phytochem. Res. 2(1), 1-12.
Vergara-Jimenez, M., Almatrafi, M.M., Fernandez, M.L., 2017. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants 6(4), 91.
Wansi, J.D., Sewald, N., Nahar, L., Martin, C., Sarker, S.D., 2019. Bioactive essential oils from the Cameroonian rain forest: A review-Part II. Trends Phytochem. Res. 3(1), 3-52.
Wansi, J.D., Sewald, N., Nahar, L., Martin, C., Sarker, S.D., 2018. Bioactive essential oils from the Cameroonian rain forest: A review-Part I. Trends. Phytochem. Res. 2(4), 187-234.
Wikandari, P.R., Yuanita, L., Herdyastuti, N., Juniariani, R.E., Cahyaningtyas, F.D., 2020. Antioxidant Properties of Single Garlic (Allium sativum) Pickle. Digital Press Life Sciences, 2, 1-5.
Yadav, R.D., Jain, S.K., Alok, S., Prajapati, S.K., Verma, A., 2011. Pongamia pinnata: an overview. Int. J. Pharm. Sci. Res. 2(3), 494.
Zhang, Q.W., Lin, L.G., Ye, W.C., 2018. Techniques for extraction and isolation of natural products: a comprehensive review. Chin. Med. 13(1), 20.
Zhu, W., Gao, J., 2008, April. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders. J. Invest. Derm. Symp. P. 13(1), 20-24.