تأثیر چهار هفته مصرف اسانس لیمو و تمرین شنا بر میزان حافظه و درد در موش‌های سوری نر بالغ
محورهای موضوعی : فصلنامه زیست شناسی جانوری
سارا احمدی زاده
1
,
عبدالحسن دولاح
2
,
مریم رفیعی راد
3
1 - گروه تربیت بدنی و علوم ورزشی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران
2 - گروه زیست شناسی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران
3 - گروه زیست شناسی، واحد ایذه، دانشگاه آزاد اسلامی، ایذه، ایران
کلید واژه: حافظه, درد, تمرین شنا, اسانس لیمو, موش سوری نر بالغ,
چکیده مقاله :
با افزایش سن برخی عملکردهای سیستم عصبی از جمله حافظه اجتنابی تضعیف می شود. اثرات مفید ورزش بر نوروژنز، افزایش سیناپس های نورونی، درمان اختلالات روانی، کمک به بهبود جراحات مغزی و پیشگیری از بیماری های نورودژنراتیو به اثبات رسیده است. از گیاهانی که در طب سنتی به اثرات ضد دردی آن اشاره شده لیموترش است؛ بنابراین در تحقیق حاضر تأثیر چهار هفته مصرف اسانس لیمو و تمرین شنا بر میزان حافظه و درد در موش سوری نر بررسی گردید. بدین منظور 40 سر موش سوری نر با وزن 5 ± 40 گرم مورد مطالعه قرار گرفت. موش ها به طور تصادفی به 4 گروه شامل کنترل، گروه شنا، گروه دریافت کننده اسانس لیموترش و گروه تمرین شنا + مصرف اسانس لیموترش تقسیم شدند. تمرین شنا شامل چهار هفته شنا در آب به مدت 30 دقیقه در هر جلسه و پنج جلسه در هفته بود و اسانس لیمو 50 میلی گرم بر کیلوگرم به روش گاواژ تجویز گردید. جهت ارزیابی حافظه اجتنابی از دستگاه شاتل باکس و با استفاده از تست تیل فیلک، میزان آستانه درد مورد سنجش قرار گرفت. نتایج نشان داد اسانس لیموترش و تمرین شنا باعث کاهش معنادار احساس درد شده است (001/0p <). همچنین مصرف توأم اسانس لیمو و تمرین شنا سبب افزایش میزان حافظه در موش سوری نر می شود (001/0p <). تمرین هوازی، به ویژه شنا، اثر مثبت بر تثبیت حافظه و کاهش آستانه درد داشته است. احتمالاً مصرف اسانس لیمو به‌دلیل وجود آنتی اکسیدان های قوی می‌تواند احساس درد را کاهش دهد و حافظه اجتنابی را بهبود ببخشد.
With age, some functions of the nervous system, including avoidance memory, are impaired. The beneficial effects of exercise on neurogenesis, increasing neuronal synapses, the treatment of mental disorders, helping improve brain injuries, and prevention of neurodegenerative diseases have been proven. Citrus limon is one of the plants mentioned in traditional medicine for its analgesic effects. Therefore, in the present study, the effect of four weeks of lemon essential oil consumption and swimming training on memory and pain in male mice was investigated. To this end, 40 male mice with a weight of 40± 5 g were studied. The mice were randomly divided into 4 groups including control, swimming group, group receiving lemon essential oil, and group of swimming training + consuming lemon essential oil. Swimming practice consisted of four weeks of swimming in water for 30 minutes per session and five sessions per week, and 50 mg/kg lemon essential oil was administered by gavage. The pain threshold was measured to evaluate the avoidance memory of the shuttle box using the tail flick test. The results showed that the essential oil of lemon and swimming training has significantly reduced pain (p < 0.001). Moreover, the combined consumption of lemon essential oil and swimming training increased memory in male mice (p < 0.001). Aerobic exercise, especially swimming, has had a positive effect on memory consolidation and reduction of pain threshold. Probably, consuming lemon essential oil due to the presence of strong antioxidants can reduce the feeling of pain and improve avoidance memory.
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