In this research, various polycyclic fused acridines were synthesized via the highly efficient and green one-step four-component reaction between isatins, dimedone, various amines, and dimethylacetylenedicarboxylates (DMAD/DEAD) in the presence of n-octyl-3-methylpipyridinium bromide ([OMePPy]+Br-) as a newly prepared ionic liquid, in absolute green situations at room temperature under solvent-free conditions. The ionic liquid characterized by 1H NMR, 13C NMR, GC-MASS, TGA/ DTG, EDX, and FESEM techniques. Utilizing an eco-friendly and simply synthesized ionic liquid, green and economic reaction media, and preparing a wide range of polycyclic fused acridines in good yields are some highlighted aspects of the reported protocol. تفاصيل المقالة

In this paper, a new nano-size ionic liquid (nIL) has been synthesized from D-phenylalanine and oxalic acid (D-Phe-OX) via a simple procedure. The obtained nIL has been characterized by the fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDAX), thermogravimetric analysis (TGA), nuclear magnetic resonance spectroscopy (1H NMR), and field emission scanning electron microscopy (FESEM), techniques. The synthesized nanocatalyst has been used for the three-component one-step synthesis of functionalized spirolactones via the condensation reaction of arylamines, DMAD and isatins. The stereoselective preparation of dispirodihydrofuranyl oxindoles has also been examined successfully through the one-step pseudo-four component condensation of isatins, amines and DMAD, respectively. تفاصيل المقالة

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined. تفاصيل المقالة

Nano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. To explore the high efficacy of the catalytic system the four-component cyclization of benzil, aryl aldehydes, ammonium acetate and anilines has also been accomplished successfully to obtain their 1,2-diaryl-4,5-diphenyl-1H-imidazole adducts. A plausible mechanism has also been expressed. The catalyst has been recovered and its reusability confirmed in 4 runs. High yields, simple operation, easy-work procedure, mild reaction conditions in addition with reusability are some advantages of this protocol. تفاصيل المقالة