A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst has been used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. تفاصيل المقالة

The expeditious synthesis of 2-aryl-benzothia/(oxa)zoles was carried out by the condensation of 2-aminothiophenol/2-aminophenol and diverse aryl aldehydes in presence of Acacia concinna as a biocatalyst under microwave irradiation. The catalytic process is associated with excellent yields, greener reaction conditions and the environmentally friendly microwave technique which are the striking features of the present protocol. تفاصيل المقالة