Introduction: Extensive evidence has shown that high intensity exercise triggers blood coagulation and improves blood fibrinolysis levels. The purpose of the present study was to investigate the effect of 12 weeks of high intensity interval training (HIIT) on the response of coagulation, anticoagulant and fibrinolytic factors of hypertensive cardiovascular patients to one bout submaximal endurance exercise (OBSEE). Methods: Out of 70 men with high blood pressure, 20 men were selected based on inclusion and exclusion criteria and randomly divided into two equal groups: an experimental group (EG) and a control group (CG). First, both groups performed OBSEE. After that, the EG performed 12 weeks of HIIT. At the end, again, both groups performed OBSEE. Blood sampling was performed just before and immediately after each session of exercise. Dependent variables were categorized into three groups including 1. Coagulation: fibrinogen(FIB), factor VIII(FVIII), prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (aPTT), platelet (PLT), mean platelet volume (MPV) 2. Anticoagulation: protein C (PC), antithrombinIII (ATIII) 3. Fibrinolytic: d-dimer (D-D), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI-I), tPA/PAI-1. To analyze the data, Shapiro- Wilk test, Factorial repeated measures ANOVA, as well as Pearson correlation coefficient were used at significant level (P ≤ 0.05). Results: HIIT caused significant increase in the rate of Vo2max (p = 0.001) and significant decrease in RHR (p = 0.001), SBP (p = 0.001) and DBP (p = 0.001). No significant difference was observed between the two groups in the response of FIB (p = 0.262), FVIII (p = 0.248), PT (p = 0.396), PTA (p = 0.646), INR (p = 0.408), aPTT (p = 0.856), PLT (p = 0.678), MPV (p = 0.223), D-D (p = 0.621), tPA (p = 0.381), PAI-1 (p = 0.353), tPA / PAI-1 (p = 0.069), PC (p = 0.147) and ATIII (p = 0.138) to OBSEE after 12 weeks HIIT. Conclusion: It seems that to observation of significant positive changes in the response of coagulation, anticoagulant, and fibrinolytic factors to one OBSEE, more than 12 weeks HIIT are required. تفاصيل المقالة

Introduction: Hypertension is considered as a major risk factor for thrombotic events. The aim of this study was to investigate the effect of one bout submaximal endurance exercise on blood coagulation and fibrinolytic factors in patients with hypertension. Methods: 20 subjects were randomly selected out of 70 adult males with hypertension (Mean ± SD; age: 60.25±4.59 yr, body mass index (BMI): 29.57± 3.68 kg/m2, body fat percentage (BFP): 20.25± 5.31%, maximal oxygen uptake34.83±2.11ml/kg/min, systolic blood pressure(SBP): 147.20±
6.43 mm Hg,diastolic blood pressure(DBP): 94.40±3.70 mm Hg). The participants carried out one bout submaximal endurance running for 30 minutes within 60 to 65% of maximal heart rate reserve (MHRR). Blood samples were immediately taken before and after exercise. Dependent variables were categorized into three groups including 1.Coagulation: fibrinogen (FIB), factor VIII (FVIII), prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time(aPTT), platelet (PLT), mean platelet volume (MPV) 2. Anticoagulation: protein C (PC), antithrombinIII (ATIII) 3. Fibrinolytic: d-dimer (D-D), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI-I), tPA/PAI-1. For normalizing research data Shapiro- Wilk test was used. Data analysis was done by paired samples t-test at a significant level of (P≤0.05). Testing of the considered assumptions was carried out by SPSS software version 19. Results: Paired sample t-test showed a significant reduction in aPTT (P=0.001), tPA (P=0.001), tPA/PAI-1(P=0.014), PV (P=0.001) and a significant increase in FIB (P=0.001), FVIII (P=0.001), PLT (P==0.001), MPV (P=0.001), PC (P=0.001) and ATIII (P=0.001) levels. There was no significant change in PT (P=0.068), PTA (P=0.156), INR (P=0.060) and D-D (P=0.436)levels. Considering the volume of plasma, no significant changes in FIB were observed (P=0.814). Conclusion: It seems that submaximal endurance exercise activates the anticoagulation system which can overcome thrombotic conditions. تفاصيل المقالة