تأثیر تمرین هوازی و کورکومین بر سطوح آپلین، مقاومت به انسولین و گلوکز در موش‌های صحرایی مبتلا به دیابت نوع 2
الموضوعات :
مرتضی ابراهیم زاده
1
(
گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
)
کمال عزیزبیگی
2
(
گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
)
خالید محمدزاده سلامت
3
(
گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
)
سامان پاشایی
4
(
گروه تربیت بدنی و علوم ورزشی، واحد سقز، دانشگاه آزاد اسلامی، سقز، ایران
)
الکلمات المفتاحية: دیابت, کورکومین, تمرین هوازی, آپلین,
ملخص المقالة :
مقدمه و هدف: پژوهش‌های پیشین تأثیر مثبت تمرین هوازی و کورکومین را بر دیابت نشان داده‌اند. هدف از پژوهش حاضر بررسی اثر تمرین هوازی با و بدون مکمل کورکومین بر سطوح آپلین، مقاومت به انسولین و گلوکز در موش های مبتلا به دیابت نوع 2 بود. مواد و روش ها: 40 سر موش صحرایی نر به‌طور تصادفی به 5 گروه 8 تایی شامل شاهد سالم، شاهد دیابتی، دیابت+کورکومین، دیابت+ تمرین هوازی، دیابت +کورکومین + تمرین هوازی تقسیم شدند. پس از اعمال مداخله بر اساس نام گروه حیوانات قربانی شدند و متغیرهای مورد نظر در نمونه‌های پلاسمایی جمع آوری شده اندازه‌گیری شدند. داده‌ها با استفاده از آزمون آنالیز واریانس یک‌طرفه آنالیز شدند و ارزش P کمتر از 05/0 به‌عنوان تفاوت معنی‌دار در نظر گرفته شد. یافته ها: نتایج نشان داد تمرین هوازی با شدت متوسط باعث افزایش سطوح آپلین (05/0P<) و کاهش مقاومت انسولینی (05/0P<) و گلوکز (05/0P<) پلاسمای موش‌های دیابتی شد. استفاده از کورکومین نیز باعث افزایش سطوح آپلین (05/0P<) و کاهش مقاومت انسولینی (05/0P<) و گلوکز (05/0P<) پلاسمای موش‌های دیابتی شد. بحث و نتیجه گیری: تمرین هوازی با شدت متوسط می‌تواند راه‌حلی مناسب برای کاهش قند خون و جلوگیری از افزایش آن در پی بیماری دیابت شود. همچنین، مصرف کورکومین در محدوده مقادیر سلامت به همراه تمرین هوازی می‌تواند بر حصول نتایج بهتر تأثیر بگذارد.
1. Cremona A, O'Gorman C, Cotter A, Saunders JandDonnelly A. Effect of exercise modality on markers of insulin sensitivity and blood glucose control in pregnancies complicated with gestational diabetes mellitus: a systematic review. Obesity Sci Pract. 2018; 4 (5): 455-67. [DOI:10.1002/osp4.283]
2. Fotovat Sh, Jalali Kh, Taftian F. The effect of eight weeks of aerobic exercise with nano-eugenol supplementation on pancreatic tissue UPC3 gene expression and serum MDA levels in rats with% J diabetes. Res Sports Sci Herbs. 2020; 1 (1): 79- 89. [DOI:10.30495/varzesh.2020.678661]
3. Azimidokht SMA, Mogharnasi M, Kargar shouroki MKandZarezade mehrizi AA. The effect of 8 weeks interval training on insulin resistance and lipid profiles in type 2 diabetic men treated with metformin . J Sport Biosci. 2015; 7 (3): 461- 76. [DOI:10.22059/jsb.2015.56260]
4. 1994. Reviews : Joslin's Diabetes Mellitus, 13th ed, by C. Ronald Kahn and Gordon C. Weir, editors (1994). Lea & Febiger; PO Box 3024, 200 Chesterfield Park- way, Malvern, PA 19355-9725. 1068 pages. 20(6):541-. [DOI:10.1177/014572179402000614]
5. Peterson MC. Circulating transforming growth factor beta-1: a partial molecular explanation for associations between hypertension, diabetes, obesity, smoking and human disease involving fibrosis. Med Sci Monitor. 2005; 11 (7): Ra229- 32. [PMID:15990699]
6. Yamauchi T, Iwabu M, Okada-Iwabu MandKadowaki T. Adiponectin receptors: a review of their structure, function and how they work. Best Practice Rese Clin Endocrin Metabol. 2014; 28 (1): 15-23. [DOI:10.1016/j.beem.2013.09.003]
7. Bełtowski J. Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity? Medical Sci Monit. 2006. 12 (6): Ra112- 9. [PMID:16733497]
8. Ladeiras-Lopes R, Ferreira-Martins JandLeite-Moreira AF. The apelinergic system: the role played in human physiology and pathology and potential therapeutic applications. Arq Bras Cardiol. 2008; 90 (5): 343- 9. [DOI:10.1590/s0066-782x2008000500012]
9. Ma WY, Yu TY, Wei JN, Hung CS, Lin MS, Liao YJ, et al. Plasma apelin: A novel biomarker for predicting diabetes. Clin Chim Acta. 2014; 435: 18- 23. [DOI:10.1016/j.cca.2014.03.030]
10. Mierzyński R, Poniedziałek-Czajkowska E, Dłuski D, Kamiński M, Mierzyńska AandLeszczyńska-Gorzelak B. The potential role of chemerin, lipocalin 2, and apelin in the diagnosis and pathophysiology of gestational diabetes mellitus. J Diabetes Res. 2021; 2021: 5547228. [DOI:10.1155/2021/5547228]
11. Castan-Laurell I, Dray C, Attané C, Duparc T, Knauf CandValet P. Apelin, diabetes, and obesity. Endocrine. 2011; 40 (1): 1- 9. [DOI:10.1007/s12020-011-9507-9]
12. Krist J, Wieder K, Klöting N, Oberbach A, Kralisch S, Wiesner T, et al. Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity. Obesity Facts. 2013; 6 (1): 57- 69. [DOI:10.1159/000348667]
13. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, Castan-Laurell I, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinol. 2005; 146 (4): 1764- 71. [DOI:10.1210/en.2004-1427]
14. Erdem G, Dogru T, Tasci I, Sonmez AandTapan S. Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus. Experiment Clin Endocrinolo Diabetes. 2008; 116 (5): 289- 92. [DOI:10.1055/s-2007-1004564]
15. Shamsi-Goushki A, Mortazavi Z, Mirshekar MA, Mohammadi M, Moradi-Kor N, Jafari-Maskouni SandShahraki M. Comparative effects of curcumin versus nano- curcumin on insulin resistance, serum levels of apelin and lipid profile in type 2 diabetic rats. Diabetes Metab Syndr Obes. 2020; 13: 2337- 46. [DOI:10.2147/DMSO.S247351]
16. Qatanani MandLazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Develop. 2077; 21 (12): 1443- 55. [DOI:10.1101/gad.1550907]
17. Wang C, Guan YandYang J. Cytokines in the progression of pancreatic β- cell dysfunction. Int J Endocrinol. 2010; 2010: 515136. [DOI:10.1155/2010/515136] [PMC2989452]
18. Arvin Z, Hosseini Sa. The effect of swimming training with coriander extract on glucose indices of rats with diabetes. J Research in sports science and medicinal plants. 2020; 1 (1): 19- 28. [DOI:10.30495 / varzesh.2020.677909]
19. Salehi Ar, Sheikh al-Islami Watani D, author Z, Yarahmadi J. The effect of swimming practice at different temperatures with cinnamon consumption on avoidance memory, spatial memory and aerobic capacity of streptozotocin-induced diabetic rats. Res Sports Sci Med Plants. 2020; 1 (1): 67- 78. [DOI:10.30495/varzesh.2020.678499]
20. Howarth FC, Marzouqi FM, Al Saeedi AM, Hameed RSandAdeghate E. The effect of a heavy exercise program on the distribution of pancreatic hormones in the streptozotocin-induced diabetic rat. JOP. 2009; 10 (5): 485- 91. [PMID:19734622]
21. Pinent M, Castell A, Baiges I, Montagut G, Arola LandArdévol A. Bioactivity of flavonoids on insulin- secreting cells. 2008; 7 (4): 299- 308. [DOI:/10.1111/j.1541-4337.2008.00048.x]
22. Işik H, Cevikbaş A, Gürer US, Kiran B, Uresin Y, Rayaman P, et al. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Principl Pract. 2010; 19 (3): 206- 11. [DOI:10.1159/000285289]
23. Rajaei F, Abedpour N, Salehnia M, Jahanihashemi H. The effect of vitrification on mouse oocyte apoptosis by cryotop method. Iran Biomed J. 2013; 17 (4): 200- 5. [DOI:10.6091/ibj.1184.2013] [PMID:23999716] [PMCID:PMC3882923]
24. Moradi Kelardeh B, Rahmati-Ahmadabad S, Farzanegi P, Helalizadeh MandAzarbayjani MA. Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease. J Bodyw Mov Ther. 2020; 24 (3): 154- 60. [DOI:10.1016/j.jbmt.2020.02.021]
25. Tehrani M, Azarbayjani MA, Kaka Gh, Hossini SA. Effects of aerobic exercise and curcumin on apoptosis: A review. JMJ. 2018; 16 (2): 58- 66. http://jmj.jums.ac.ir/article-1-1077-fa.html
26. Feizolahi F, Azarbayjani MA, Nasehi M, Peeri M. Comparison the effect of short-term swimming training and curcumin supplementation on damaged spatial memory after binge ethanol drinking in male rats: preliminary report. JMD. 2017; 16 (61) :174- 184. [DOR:20.1001.1.2717204.2017.16.61.26.7]
27. Daniel S, Limson JL, Dairam A, Watkins GMandDaya S. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorganic Biochem. 2004; 98 (2): 266- 75. [DOI:10.1016/j.jinorgbio.2003.10.014]
28. Shirvani H, Ghanbari-Niaki A, Rahmati-Ahmadabad SandSobhani VJIJoAEP. Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression. Int J Apl Exer Physiol. 2017; 6 (1): 72-85. [DOI:10.22631/ijaep.v6i1.118]
29. Rahmati-Ahmadabad S, Azarbayjani MA, Farzanegi P, Moradi L. High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats. Eur J Prev Cardiol. 2015; 2047487319887828. [DOI:10.1177/2047487319887828]
30. Yildirim OandBüyükbingöl Z. Effect of cobalt on the oxidative status in heart and aorta of streptozotocin-induced diabetic rats. Cell Biochem Function. 2003; 21 (1): 27- 33. [DOI:10.1002/cbf.995]
31. Altan MF, Kanter M, Donmez S, Kartal MEandBuyukbas S. Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochemica. 2007; 109 (4): 304-14. [DOI:10.1016/j.acthis.2007.02.006] [PMID:17395251]
32. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346 (6): 393- 403. [DOI:10.1056/NEJMoa012512] [PMC:1370926]
33. Kazemi F, Ebrahim KandZahedi Asl S. Effects of aerobic training on plasma concentration of apelin and insulin resistance in type 2 diabetic rats. Gene. 2014; 36 (3): 62-7. [DOI:10.1016/j.gene.2018.04.003] [PMID:29626513]
34. Kadoglou NPE, Vrabas IS, Kapelouzou A, Lampropoulos S, Sailer N, Kostakis A, et al. The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes. Med Sci Monitor. 2012; 18 (5): CR290- CR5. [DOI:10.12659/msm.882734]
35. Abbassi-Daloii A, Abdi A, Yazdani-Tapesari H, Salehpour M, Rostami-Angasi Z, Yahyaei B. Effect of 8 weeks aerobic training on plasma apelin in male rats treated with L-NAME. J Feyz 2016; 20 (2): 118- 24. http://feyz.kaums.ac.ir/article-1-3027-en.html
36. Zhu S, Sun F, Li W, Cao Y, Wang C, Wang Y, et al. Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes. Mol Cell Biochem. 2011; 353 (1): 305- 13. [DOI:10.1007/s11010-011-0799-0]
37. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003; 42 (5): 861- 8. [DOI:10.1016/S0735-1097(03)00848-9]
38. Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes. 2004; 53 (2): 294- 305. [DOI:10.2337/diabetes.53.2.294]
39. Yue P, Jin H, Aillaud M, Deng AC, Azuma J, Asagami T, et al. Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab. 2010; 298 (1): E59- E67. [DOI:10.1152/ajpendo.00385.2009]
40. Massi-Benedetti M, Herz M, Pfeiffer C. The effects of acute exercise on metabolic control in type II diabetic patients treated with glimepiride or glibenclamide. Hormone Metabol Res Hormon. 1996; 28 (9): 451- 5. [DOI:10.1055/s-2007-979836]
41. Bruce CR, Kriketos AD, Cooney GJ, Hawley JA. Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes. Diabetologia. 2004; 47 (1): 23- 30. [DOI:10.1007/s00125-003-1265-7]
42. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil. 2005; 86 (8):1527- 33. [DOI:10.1016/j.apmr.2005.01.007]
_||_