اثر 12 هفته تمرین HIIT بر بیان GLUT4 در عضله دوقلوی رت های دیابتی
الموضوعات : Role of Genes in Health
هانیه اقبالی
1
,
فاطمه غفاری
2
,
مسلم شریفی
3
,
ایمان قنبری
4
1 - دانشگاه ازاد اسلامی
2 - دانشگاه ازاد اسلامی واحد قائمشهر
3 - گروه تربیت بدنی ،دانشکده مهارت و کارافرینی،دانشگاه ازاد واحد بابل،بابل، ایران
4 - هیات علمی دانشگاه
الکلمات المفتاحية: دیابت نوع 2, تمرین HIIT , بیان ژن GLUT4, عضله اسکلتی, مقاومت انسولین,
ملخص المقالة :
هدف: این مطالعه با هدف تعیین اثر 12 هفته تمرین HIIT بر بیان ژن GLUT4 در عضله دوقلو، گلوکز و مقاومت انسولین در رت های دیابتی نوع 2 انجام گرفت.
روش کار: جامعه آماری را همه رت های نر ویستار انستیتو پاستور ایران تشکیل می دهند که از بین آنها 14 رت 10 هفته ای در دامنه وزن 20 ± 220 گرم انتخاب شدند و توسط تزریق درون صفاقی نیکوتین آمید + STZ دیابتی نوع 2 شدند. سپس به شیوه تصادفی به گروه های HIIT (12 هفته، 5 جلسه در هفته، 7 = n) و کنترل (7 = n) تقسیم شدند. سطوح ناشتایی گلوکز، انسولین، مقاومت انسولین و بیان ژن GLUT4 در عضله دوقلو دو گروه بعد از آخرین جلسه تمرینی اندازه گیری و توسط آزمون تی مستقل بین دو گروه مقایسه شدند.
نتایج: تمرین HIIT به کاهش معنی دار گلوکز ناشتا و افزایش بیان GLUT4 در عضله دوقلو در مقایسه با گروه کنترل منجر شد. در مقایسه با گروه کنترل، شاخص مقاومت انسولین تغییر معنی داری پیدا نکرد.
نتیجه گیری: اجرای تمرینات HIIT مستقل از مقاومت انسولین، سطوح گلوکز رت های دیابتی نوع 2 را بواسطه افزایش بیان GLUT4 در عضلات اسکلتی متاثر می کند. با این وجود، اجرای مطالعات بیشتر با هدف شناخت دیگر مکانیسم های عهده دار هموستاز گلوکز پیشنهاد می شود.
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