An Overview of the Biological Effects of Kefir: An Amazing Beverage
الموضوعات : Food and Health
Mohaddeseh Larypoor
1
,
Shahrzad Sadeghi Amjad
2
,
Hoora Dadgostar
3
,
Ali Akhavan Sepahi
4
1 - Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran North Branch, Tehran, Iran
2 - Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran Central Branch, Tehran, Iran.
3 - 3 Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran North Branch, Tehran, Iran.
4 - Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
الکلمات المفتاحية: Kefir, Probiotics, Postbiotics, Prebiotics, Medicinal food supplement,
ملخص المقالة :
The occurrence of global epidemiological changes, such as cardiovascular diseases, cancer, diabetes, etc., has led researchers to examine the significant causal relationship between the disturbance of microbiota balance and the prevalence of these diseases. It has been determined that there is a direct relationship between them. Fermented foods have held a significant place in the human diet for a long time. The development of chemical drugs and their side effects has led people to consume more beneficial foods. Kefir is a natural beverage containing helpful microorganisms and several critical bioactive compounds. The presence of mineral compounds, vitamins, and proteins makes this beverage a particularly unique combination. Kefir is produced in two forms, dairy, and non-dairy, and its sensory and physicochemical characteristics depend on temperature, substrate, microbial consortium, etc. In this article, in addition to examining the general characteristics of kefir and its production method, the valuable properties of kefir, including its antimicrobial, anti-cancer, anti-fat accumulation and obesity, and antiviral effects, as well as its impact on reducing the symptoms of neurological and skin diseases, will be discussed. Additionally, the effects of kefir's probiotic, postbiotic, and prebiotic aspects will be investigated. Finally, kefir can be considered a medicinal food supplement.
1. Peluzio MdCG, Dias MdMe, Martinez JA, Milagro FI. Kefir and intestinal microbiota modulation: implications in human health. Frontiers in nutrition. 2021;8:638740.
2. de Lima Barros SÉ, dos Santos Rocha C, de Moura MSB, Barcelos MP, da Silva Hage-Melim LI. Potential beneficial effects of kefir and its postbiotic, kefiran, on child food allergy. Food & Function. 2021;12(9):3770-86.
3. Apalowo OE, Adegoye GA, Mbogori T, Kandiah J, Obuotor TM. Nutritional Characteristics, Health Impact, and Applications of Kefir. Foods. 2024;13(7):1026.
4. Shams K, Larypoor M, Salimian J. The immunomodulatory effects of Candida albicans isolated from the normal gastrointestinal microbiome of the elderly on colorectal cancer. Medical Oncology. 2021;38(12):140.
5. Bozkir E, Yilmaz B, Sharma H, Esatbeyoglu T, Ozogul F. Challenges in water kefir production and limitations in human consumption: A comprehensive review of current knowledge. Heliyon. 2024.
6. Abolghasemi H, Larypoor M, Hosseini F. Probiotic effects of Metschnikowia isolated from dairy products aquatic environments. International Journal of Molecular and Clinical Microbiology. 2022;12(2):1692-703.
7. Larypoor M. An overview of food synthetic dietary supplements. Food Hygiene. 2021;11(343):1-22.
8. Farag MA, Jomaa SA, Abd El-Wahed A, R. El-Seedi H. The many faces of kefir fermented dairy products: Quality characteristics, flavour chemistry, nutritional value, health benefits, and safety. Nutrients. 2020;12(2):346.
9. Vieira CP, Rosario AIL, Lelis CA, Rekowsky BSS, Carvalho APA, Rosário DKA, et al. Bioactive compounds from kefir and their potential benefits on health: a systematic review and meta‐analysis. Oxidative medicine and cellular longevity. 2021;2021(1):9081738.
10. Guzel-Seydim ZB, Gökırmaklı Ç, Greene AK. A comparison of milk kefir and water kefir: Physical, chemical, microbiological and functional properties. Trends in Food Science & Technology. 2021;113:42-53.
11. Dadgostar H, Sadeghi Amjad S, Larypoor M. A review of the binding properties of kombucha to toxins. Journal of Applied Microbiology in Food Industry. 2024;9(4):72-97.
12. Azizi NF, Kumar MR, Yeap SK, Abdullah JO, Khalid M, Omar AR, et al. Kefir and its biological activities. Foods. 2021;10(6):1210.
13. Aktas DK, Aydin S. Production of new functional coconut milk kefir with blueberry extract and microalgae: the comparison of the prebiotic potentials on lactic acid bacteria of kefir grain and biochemical characteristics. Journal of Food Science and Technology. 2024:1-12.
14. Hamida RS, Shami A, Ali MA, Almohawes ZN, Mohammed AE, Bin-Meferij MM. Kefir: A protective dietary supplementation against viral infection. Biomedicine & Pharmacotherapy. 2021;133:110974.
15. Bengoa AA, Dardis C, Gagliarini N, Garrote GL, Abraham AG. Exopolysaccharides from Lactobacillus paracasei isolated from kefir as potential bioactive compounds for microbiota modulation. Frontiers in Microbiology. 2020;11:583254.
16. Tan LL, Ngiam JJ, Sim ESZ, Conway PL, Loo SCJ. Liquorilactobacillus satsumensis from water kefir yields α-glucan polysaccharides with prebiotic and synbiotic qualities. Carbohydrate Polymers. 2022;290:119515.
17. Hurtado-Romero A, Del Toro-Barbosa M, Gradilla-Hernández MS, Garcia-Amezquita LE, García-Cayuela T. Probiotic properties, prebiotic fermentability, and GABA-producing capacity of microorganisms isolated from Mexican milk kefir grains: a clustering evaluation for functional dairy food applications. Foods. 2021;10(10):2275.
18. Likotrafiti E, Valavani P, Argiriou A, Rhoades J. In vitro evaluation of potential antimicrobial synbiotics using Lactobacillus kefiri isolated from kefir grains. International Dairy Journal. 2015;45:23-30.
19. Koh WY, Utra U, Ahmad R, Rather IA, Park Y-H. Evaluation of probiotic potential and anti-hyperglycemic properties of a novel Lactobacillus strain isolated from water kefir grains. Food Science and Biotechnology. 2018;27:1369-76.
20. Miedel EL, Hankenson FC. Biology and diseases of hamsters. Laboratory animal medicine: Elsevier; 2015. p. 209-45.
21. Romero-Luna HE, Peredo-Lovillo A, Hernández-Mendoza A, Hernández-Sánchez H, Cauich-Sánchez PI, Ribas-Aparicio RM, et al. Probiotic potential of Lactobacillus paracasei CT12 isolated from water kefir grains (Tibicos). Current Microbiology. 2020;77:2584-92.
22. Leite AM, Miguel M, Peixoto R, Ruas-Madiedo P, Paschoalin V, Mayo B, et al. Probiotic potential of selected lactic acid bacteria strains isolated from Brazilian kefir grains. Journal of dairy science. 2015;98(6):3622-32.
23. Maione A, Imparato M, Buonanno A, Salvatore MM, Carraturo F, de Alteriis E, et al. Evaluation of Potential Probiotic Properties and In Vivo Safety of Lactic Acid Bacteria and Yeast Strains Isolated from Traditional Home-Made Kefir. Foods. 2024;13(7):1013.
24. Ravali SD, Bandekar PG. Physicochemical and microbiological analysis of the probiotic Kefir beverage. Emergent Life Sciences Research. 2024;10:97-103.
25. Talib N, Mohamad NE, Yeap SK, Hussin Y, Aziz MNM, Masarudin MJ, et al. Isolation and characterization of Lactobacillus spp. from kefir samples in Malaysia. Molecules. 2019;24(14):2606.
26. Alves E, Gregório J, Rijo P, Rosado C, Monteiro Rodrigues L. Kefir and the gut–skin axis. International Journal of Environmental Research and Public Health. 2022;19(21):13791.
27. Rodrigues KL, Caputo LRG, Carvalho JCT, Evangelista J, Schneedorf JM. Antimicrobial and healing activity of kefir and kefiran extract. International journal of antimicrobial agents. 2005;25(5):404-8.
28. Xie N, Zhou T, Li B. Kefir yeasts enhance probiotic potentials of Lactobacillus paracasei H9: the positive effects of coaggregation between the two strains. Food Research International. 2012;45(1):394-401.
29. Seo K-H, Jeong J, Kim H. Synergistic effects of heat-killed kefir paraprobiotics and flavonoid-rich prebiotics on western diet-induced obesity. Nutrients. 2020;12(8):2465.
30. Culpepper T. The effects of kefir and kefir components on immune and metabolic physiology in pre-clinical studies: A narrative review. Cureus. 2022;14(8).
31. Kim H-J, Youn H-Y, Moon J-S, Kim H, Seo K-H. Comparative anti-microbial and anti-biofilm activities of postbiotics derived from kefir and normal raw milk lactic acid bacteria against bovine mastitis pathogens. LWT. 2024;191:115699.
32. da Anunciação TA, Guedes JDS, Tavares PPLG, de Melo Borges FE, Ferreira DD, Costa JAV, et al. Biological Significance of Probiotic Microorganisms from Kefir and Kombucha: A Review. Microorganisms. 2024;12(6):1127.
33. de Souza HF, Monteiro GF, Bogáz LT, Freire ENS, Pereira KN, de Carvalho MV, et al. Bibliometric analysis of water kefir and milk kefir in probiotic foods from 2013 to 2022: A critical review of recent applications and prospects. Food Research International. 2023:113716.
34. John SM, Deeseenthum S. Properties and benefits of kefir-A review. Songklanakarin Journal of Science & Technology. 2015;37(3).
35. Huseini HF, Rahimzadeh G, Fazeli MR, Mehrazma M, Salehi M. Evaluation of wound healing activities of kefir products. Burns. 2012;38(5):719-23.
36. Ebner J, Arslan AA, Fedorova M, Hoffmann R, Küçükçetin A, Pischetsrieder M. Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains. Journal of proteomics. 2015;117:41-57.
37. Friques AG, Arpini CM, Kalil IC, Gava AL, Leal MA, Porto ML, et al. Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats. Journal of Translational Medicine. 2015;13:1-16.
38. Barboza J, Porto M, de Almeida L, Freitas F, Vasquez E. Probiotic Kefir Prevents Renal Ischemia-Reperfusion Injury through Reduced Oxidative Stress and Apoptosis in Wistar Rats. J Urol Ren Dis. 2020;5:1178.
39. Jeong CH, Cheng WN, Kwon HC, Kim D-H, Seo K-H, Choi Y, et al. Effects of kefir on doxorubicin-induced multidrug resistance in human colorectal cancer cells. Journal of Functional Foods. 2021;78:104371.
40. Ghoneum M, Gimzewski J. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. International journal of oncology. 2014;44(3):830-7.
41. Alsha’ar IA, Aloklah B, Al-Deen RB, Aljamali M, Alkadry R, Albiski F. In Vitro AnticancerPropertiesof Kefirand Kefir Products Produced by aNovel Method in Syria. Int J Pharm Sci Invent ISSN. 2017;6:2319-670.
42. Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncology Reports. 2015;34(4):1659-66.
43. Nagira T, Narisawa J, Teruya K, Katakura Y, Shim S-Y, Kusumoto K-i, et al. Suppression of UVC-induced cell damage and enhancement of DNA repair by the fermented milk, Kefir. Cytotechnology. 2002;40:125-37.
44. Ostadrahimi A, Taghizadeh A, Mobasseri M, Farrin N, Payahoo L, Gheshlaghi ZB, et al. Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Iranian journal of public health. 2015;44(2):228.
45. Carasi P, Díaz M, Racedo SM, De Antoni G, Urdaci MC, Serradell MdlÁ. Safety characterization and antimicrobial properties of kefir‐isolated Lactobacillus kefiri. BioMed Research International. 2014;2014(1):208974.
46. Jeong D, Kim D-H, Kang I-B, Kim H, Song K-Y, Kim H-S, et al. Characterization and antibacterial activity of a novel exopolysaccharide produced by Lactobacillus kefiranofaciens DN1 isolated from kefir. Food Control. 2017;78:436-42.
47. Zanirati DF, Abatemarco Jr M, de Cicco Sandes SH, Nicoli JR, Nunes ÁC, Neumann E. Selection of lactic acid bacteria from Brazilian kefir grains for potential use as starter or probiotic cultures. Anaerobe. 2015;32:70-6.
48. Lucena MdA, Ramos IFdS, Geronço MS, de Araújo R, da Silva Filho FL, da Silva LMLR, et al. Biopolymer from water kefir as a potential clean-label ingredient for health applications: evaluation of new properties. Molecules. 2022;27(12):3895.
49. Talib N, Mohamad NE, Yeap SK, Ho CL, Masarudin MJ, Abd-Aziz S, et al. Anti-Diabetic Effect of Lactobacillus Paracasei Isolated from Malaysian Water Kefir Grains. Probiotics and Antimicrobial Proteins. 2023:1-20.
50. Shehata MG, Abd El-Aziz NM, Mehany T, Simal-Gandara J. Taro leaves extract and probiotic lactic acid bacteria: A synergistic approach to improve antioxidant capacity and bioaccessibility in fermented milk beverages. LWT. 2023;187:115280.
51. Tiss M, Souiy Z, Ben Abdeljelil N, Njima M, Achour L, Hamden K. Fermented soy milk prepared using kefir grains prevents and ameliorates obesity, type 2 diabetes, hyperlipidemia and Liver-Kidney toxicities in HFFD-rats. Journal of Functional Foods. 2020;67:103869.
52. Calatayud M, Börner RA, Ghyselinck J, Verstrepen L, Medts JD, Abbeele PVd, et al. Water kefir and derived pasteurized beverages modulate gut microbiota, intestinal permeability and cytokine production in vitro. Nutrients. 2021;13(11):3897.
53. Esener OBB, Balkan B, Armutak E, Uvez A, Yildiz G, Hafizoglu M, et al. Donkey milk kefir induces apoptosis and suppresses proliferation of Ehrlich ascites carcinoma by decreasing iNOS in mice. Biotechnic & Histochemistry. 2018;93(6):424-31.
54. Bourrie BC, Ju T, Fouhse JM, Forgie AJ, Sergi C, Cotter PD, et al. Kefir microbial composition is a deciding factor in the physiological impact of kefir in a mouse model of obesity. British Journal of Nutrition. 2021;125(2):129-38.
55. Malta SM, Batista LL, Silva HCG, Franco RR, Silva MH, Rodrigues TS, et al. Identification of bioactive peptides from a Brazilian kefir sample, and their anti-Alzheimer potential in Drosophila melanogaster. Scientific Reports. 2022;12(1):11065.
56. Tu M-Y, Han K-Y, Chang GR-L, Lai G-D, Chang K-Y, Chen C-F, et al. Kefir peptides prevent estrogen deficiency-induced bone loss and modulate the structure of the gut microbiota in ovariectomized mice. Nutrients. 2020;12(11):3432.
57. van de Wouw M, Walsh AM, Crispie F, van Leuven L, Lyte JM, Boehme M, et al. Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse. Microbiome. 2020;8:1-20.
