Possibilities for Improvement of Humoral Innate Immunity in Turkeys and Hens in Conditions of Thermal Stress by the Immunomodulator Immunobeta®
الموضوعات :ن. بوزاکووا 1 , ل. سوتیرو 2 , س. دنو 3 , ت. کوینارسکی 4
1 - Department of Animal Hygiene, Ethology and Animal Protection, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
2 - Department of Animal Genetics, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
3 - Department of Biochemistry and Microbiology, Faculty of Agriculture, Trakia University, Stara Zagora, Bulgaria
4 - Department of Animal Genetics, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
الکلمات المفتاحية: lysozyme, beta-lysins, complement, hens, immunobeta, turkeys,
ملخص المقالة :
The experiments for evaluation of the effect of Immunobeta® were performed with turkeys and organically reared layer hens. Turkeys received Immunobeta® at a dose of 4 g/kg feed during the beginning of lay (cold period), thermoneutral period and hot summer period. In hens, two dietary levels of Immunobeta® were tested: 2 g/kg and 4 g/kg. Blood serum and egg white lysozyme levels, alternative pathway of complement activation (APCA) and beta-lysins concentrations were determined. It was found out that Immunobeta® had a beneficial effect on serum lysozyme, APCA activity and beta-lysins in turkeys and hens. The lysozyme concentration in egg white was significantly higher in eggs produced by birds treated with both doses of the immunomodulator. Immunobeta®, offered at a dose of 4.0 g/kg feed had a beneficial effect on natural humoral immunity factors. Applied at a dose of 4.0 g/kg, the tested immunomodulator increased significantly egg white lysozyme concentrations in hens, presuming a higher shelf life of eggs and possibly, better protection of chick embryos.
Al-Mansour S., Al-Khalf A., Al-Homidan I. and Fathi M.M. (2011). Feed efficiency and blood hematology of broiler chicks given a diet supplemented with yeast culture. Int. J. Poult. Sci. 10, 603-607.
Bozakova N.A. and Gerzilov V. (2014). Opportunities for the welfare improvement of laying hens under semi-open rearing during the cold period with arginine and vitamin C supplementation. Turkish J. Agric. Nat. Sci. 1, 793-798.
Bozakova N.A., Dimitrov D., Sotirov L., Petrov P., Gerzilov V. and Koynarski T. (2016). Effect of immunomodulator Immunobeta on histological features of intestinal villi and crypts in broiler chickens. Cienc. Tec. Vitivinic. 31, 141-149.
Bozakova N.А., Gerzilov V., Atanasov A. and Chukacheva I. (2013b). Welfare assessment of breeder hens supplemented with zinc and vitamin С during the cold winter period. Bulgarian J. Vet. Med. 16, 170-178.
Bozakova N.A., Girginov D. and Atanasov A. (2013а). Welfare of Barred Plymouth Rock poultry flocks supplemented with zinc, vitamin C and L-arginine during the hot summer period using a mathematical assessment model. Pp. 23-26 in Proc. 16th ISAH Congr. Nanjing, China.
Bozakova N.А., Oblakova M., Stoyanchev K., Yotova I. and Lalev M. (2009). Ethological aspects of improving the welfare of turkey breeders in the hot summer period by dietary L-arginine supplementation. Bulgarian J. Vet. Med. 12, 185-191.
Bozakova N.A., Popova-Ralcheva S., Sredkova V., Gerzilov V., Atanasov A. and Georgieva N. (2012). Mathematical welfare assessment model of chicken breeder flocks. Bulgarian J. Agric. Sci. 18, 278-287.
Bozakova N.A, Sotirov L., Koynarski T. and Gundasheva D. (2017). Effect of immunomodulator immunobeta on humoral innate and acquired immune response in layer hens. Pakistan Vet. J. 38, 438-441.
Buharin O.V., Luda A.P. and Bigeev R.I. (1977). Fotonefelometricheskij metod opredelenia beta-lizinov v sivarotke krovi. Pp 52-53 in Sistema Beta-Lizina I ee Rol v Klinicheskoj I Eksperimentalnoj Medicine. S.P. Karpov, Ed. Izdatelstvo Tomskogo Universiteta, Tomsk, Russia.
Chen C.Y., Chen S.W. and Wang H.T. (2017). Effect of supplementation of yeast with bacteriocin and Lactobacillus culture on growth performance, cecal fermentation, microbiota composition, and blood characteristics in broiler chickens. Asian-Australasian J. Anim. Sci. 30, 211-220.
Czech A., Merska M. and Ognik K. (2014). Blood immunological and biochemical indicators in turkey hens fed diets with a different content of the yeast Yarrowia lipolytica. Ann. Anim. Sci. 14, 935-946.
Denev S.A. (1996). Probiotics-past, present and future. Bulgarian J. Agric. Sci. 2, 445-474.
Denev S.A. (2006). Role of Lactobacilli in gastrointestinal ecosystem. Bulgarian J. Agric. Sci. 12, 63-114.
Denev S.A. (2008). Ecological alternatives of antibiotic growth promoters in the animal husbandry and aquaculture. D Sc. Thesis. Trakia Univ., Stara Zagora, Bulgaria.
Denev S.A. (2006a). Effect of different growth promoters on the cecal microflora and performance of broiler chickens. Bulgarian J. Agric. Sci. 12, 461-474.
Denev S.A., Dinev I., Nikiforov I. and Koinarski V. (2006b). Effect of mananoligosaccharides on composition of the cecal microflora and performance of broiler chickens. Bulgarian J. Ecol. Sci. 5, 10-16.
Denev S.A., Staykov Y., Moutafchieva R. and Beev R.G. (2009). Microbial ecology of the gastrointestinal tract of fish and the potential application of probiotics and prebiotics in finfish aquaculture. Int. Aquat. Res. 1, 1-29.
Denev S.A., Suzuki I. and Kimoto H. (2000). Role of Lactobacilli in human and animal health. Anim. Sci. J. 71, 549-562.
Fathi M.M., Al-Mansour S., Al-Homidan A., Al-Khalaf A. and Al-Damegh M. (2012). Effect of yeast culture supplementation on carcass yield and humoral immune response of broiler chicks. Vet. World. 5, 651-657.
Gao J., Zhang H.J., Yu S.H., Wu S.G., Yoon I., Quigley J., Gao Y.P. and Qi G.H. (2008). Effects of yeast culture in broiler diets on performance and immuno-modulatory functions. Poult. Sci. 87, 1377-1384.
Gospodinova K., Rumen K., Sotirov L., Bonovska M. and Angelov A. (2013). Quantitative assessment of interferon in blood serum of layer hens following treatment with polybacterial immunomodulator. Pp. 89 in Proc. 8th Balkan Congr. Microbiol. Veliko Tarnovo, Bulgaria.
Huff G.R., Huff W.E. and Jalukar S. (2013). The effects of yeast feed supplementation on turkey performance and pathogen colonization in a transport stress / Escherichia coli challenge. Poult. Sci. 92, 655-662.
Huyghebaert G. and Ducatelle Van Immerseel R.F. (2011). An update on alternatives to antimicrobial growth promoters for broilers. Vet. J. 187, 182-188.
Iacono V.J., Mackay B.J., DiRienzo S.H. and Pollock J.J. (1980). Selective antibacterial properties of lysozyme for oral microorganisms. Infect. Immun. 29, 623-632.
Karakolev R., Sotirov L. and Bonovska M. (2013a). Quantitative assessment of lysozyme and complement in blood serum of layer hens treated with polybacterial immunomodulator. Pp. 89 in Proc. 8th Balkan Congr. Microbiol. Veliko Tarnovo, Bulgaria.
Karakolev R., Sotirov L., Bonovska M., Gospodinova K., Nikolov D., Angelov A., Koynarski T. and Petkov P. (2013b). Influence of age, technologies of growing and polybacterial immunomodulator on serum lysozyme concentrations and complement activity in laying hens. Pp. 90 in Proc. 8th Balkan Congr. Microbiol. Veliko Tarnovo, Bulgaria.
Kovitvadhi A., Chundang P., Tirawattanawanich C., Prathumpai W., Methacanon P. and Chokpipatpol K. (2019). Effects of dietary supplementation with different level and molecular weight of fungal β-glucan on performances, health and meat quality in broilers. Asian-Australasian J. Anim. Sci. 32(10), 1548-1557.
Leitch E.C. and Willcox M.D.P. (1999). Elucidation of the antistaphylococcal action of lactoferrin and lysozyme. J. Med. Microbiol. 48, 867-871.
Lie O., Solbu H. and Sued M. (1985). Markers for resistance to infection in dairy cattle. Ph D. Thesis. National Veterinary Institute, Oslo, Norway.
Pangburn M.K. and Müller-Eberhard H.J. (1984). The alternative pathway of complement. Springer Semin. Immunopathol. 7, 163-192.
Pournazari M., Qotbi A.A.A., Seidavi A.R. and Corazzin M. (2017). Prebiotics, probiotics and thyme (Thymus vulgaris) for broilers: Performance, carcass traits and blood variables. Rev. Colomb. Cienc. Pec. 30, 3-10.
Sadeghı A.A., Mohamma A., Shawrang P. and Amınafshar M. (2013). Immune responses to dietary inclusion of prebiotic-based mannan-oligosaccharide and β-glucan in broiler chicks challenged with Salmonella enteritidis. Turkish J. Vet. Anim. Sci. 37, 206-213.
Shanmugasundaram R., Sifri M. and Selvaraj R.K. (2013). Effect of yeast cell product (CitriStim) supplementation on broiler performance and intestinal immune cell parameters during an experimental coccidial infection. Poult. Sci. 92, 358-363.
Shao Y., Guo Y. and Wang Z. (2013). β-1,3/1,6-glucan alleviated intestinal mucosal barrier impairment of broiler chickens challenged with Salmonella enterica serovar Typhimurium. Poult. Sci. 92, 1764-1773.
Silva V.K., Della Torre da Silva J., Torres K.A.A., de Faria Filho D.E., Hirota Hada H. and Barbosa de Moraes V.M. (2009). Humoral immune response of broilers fed diets containing yeast extract and prebiotics in the prestart phase and raised at different temperatures. J. Appl. Poult. Res. 18, 530-540.
Sotirov L. (1986). Method for determination of the alternative pathway of complement activation in some animals and man. Pр. 1-10 in 4th Sci. Conf. Agric. Stara Zagora, Bulgaria.
Sotirov L., Denev S., Tsachev I., Lalev M., Oblakova M. and Porfirova Z. (2001). Effect of different growth promoters on lysozyme and complement activity. II. Studing in turkeys. Rev. Med. Vet. 152, 67-70.
Sotirov L., Denev S.A. and Georgieva V.K. (2000). Effect of different growth promoters on lysozyme and complement activity of broiler chicks. Bulgarian J. Agric. Sci. 6, 75-82.
Sotirov L., Goundasheva D., Andonova M., Denev S., Dimitrov M. and Vassilev N. (2007). Sel-Plex®and sodium selenite dietary supplements with resulting serum lysozyme and complement activities in sows and progeny during post-partum periods. Trakia J. Sci. 5, 20-27.
Staykov Y., Spring P., Denev S. and Sweetman J. (2007). Effect of a mannan oligosaccharide on the growth performance and immune status of rainbow trout (Oncorhynchus mykiss). Aquac. Int. 15, 153-161.
Tayeri V., Seidavi A.R., Asadpour L. and Phillips C.J.C. (2018). A comparison of the effects of antibiotics, probiotics, synbiotics and prebiotics on the performance and carcass characteristics of broilers. Vet. Res. Commun. 42, 195-207.
Vahabi-Asil O., Bouyeh M., Qotbi A., Kadim I.T., Seidavi A., Centoducati G., Laudadio V. and Tufarelli V. (2017). Effects of a prebiotic on growth performance, blood parameters and immunity response of turkeys fed low protein diets. European Poult. Sci. 81, 1-12.
Valtchev I., Koynarski T., Sotirov L., Nikolov Y. and Petkov P. (2015). Effect of aflatoxin B1 on Moulard duck’s natural immunity. Pakistan Vet. J. 35, 67-70.
Yin Y.L., Tang Z.R., Sun Z.H., Liu Z.Q., Li T.J., Huang R.L., Ruan Z., Deng Z.Y., Gao B., Chen L.X., Wu C.Y. and Kim S.W. (2008). Effect of galacto-mannan-oligosaccharides or chitosan supplementation on cytoimmunity and humoral immunity in early-weaned piglets. Asian-Australasian J. Anim. Sci. 21(5), 723-731.
Zhang R., Wu L., Eckert T., Burg-Roderfeld M., Rojas-Macias M.A., Lütteke T., Krylov V.B., Argunov D.A., Datta A., Markart P., Guenther A., Norden B., Schauer R., Bhunia A., Enani M.A., Billeter M., Scheidig A.J., Nifantiev N.E. and Siebert H.C. (2017). Lysozyme’s lectin-like characteristics facilitates its immune defense function. Q. Rev. Biophys. 50, 1-12.
Zhang S., Liao B., Li X., Li L., Ma L. and Yan X. (2012). Effects of yeast cell walls on performance and immune responses of cyclosporine A-treated, immunosuppressed broiler chickens. Brittish J. Nutr. 10, 858-866.
Zhang Z.F. and Kim I.H. (2014). Effects of multistrain probiotics on growth performance, apparent ileal nutrient digestibility, blood characteristics, cecal microbial shedding, and excreta odor contents in broilers. Poult. Sci. 93, 364-370.
