Bibliometric analysis of Murraya koenigii (L.) Spreng research: Trends and hotspots

Subject Areas : Pharmacognosy

Yuvianti Dwi Franyoto ¹ , Arief Nurrochmad ² , Nanang Fakhrudin ^{3 *}

1 - Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
2 - Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Sekip Utara, Yogyakarta, 55281, Indonesia
3 - Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia

Received: 2024-11-15 Accepted : 2025-06-22 Published : 2025-06-22

Keywords: Bibliometric analysis, Herbal medicine, Murraya koenigii, Scientific production, Scopus database, Rstudio, VOSviewer,

Abstract :

This paper aims to establish the significance of its studies within the current research landscape and to investigate their methodologies, conclusions, and trends.  Utilizing the search term “Murraya koenigii,” we examined Scopus to identify bibliometric trends and hotspots. To accomplish this aim, 735 original publications published between 2013 and 2025 were retrieved and analyzed using bibliometric analysis, which was based on the Scopus Dataset results. BibTex and CVS (comma-separated values) files containing the data were exported, and Bibliometrix was implemented for the analysis. Studies on M. koenigii have been steadily increasing; 889 publications were identified in the Scopus database. Research articles accounted for 82.7% of the publications, followed by reviews (10.6%) and book chapters (3.1%). The findings presented here provide a preliminary visual summary of the scientific output of M. koenigii, taking into consideration the authors, study topics, journal citation coupling, and keyword analysis.

References:

Adebajo, A.C., Ayoola, O.F., Iwalewa, E.O., Akindahunsi, A.A., Omisore, N.O.A., Adewunmi, C.O., Adenowo, T.K., 2006. Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria. Phytomedicine 13(4), 246-254.
https://doi.org/10.1016/j.phymed.2004.12.002.
Agbo, F.J., Oyelere, S.S., Suhonen, J., Tukiainen, M., 2021. Scientific production and thematic breakthroughs in smart learning environments: A bibliometric analysis. Smart Learn. Environ. 8(1), 1-25.
https://doi.org/10.1186/s40561-020-00145-4.
Ambreen, G., Siddiq, A., Hussain, K., Hussain, A.S., Naz, Z., 2020. Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii. BMC Complement. Med. Ther. 20(1), 222.
https://doi.org/10.1186/s12906-020-03012-4.
Amna, U., Halimatussakdiah, Wahyuningsih, P., Saidi, N., Nasution, R. 2019. Evaluation of cytotoxic activity from Temurui (Murraya koenigii [Linn.] Spreng) leaf extracts against HeLa cell line using MTT assay. J. Adv. Pharm. Technol. Res. 10(2), 51-55.
https://doi.org/10.4103/japtr.JAPTR_373_18.
Aria, M., Cuccurullo, C. 2017. Bibliometrix: An R-tool for comprehensive science mapping analysis. J. Informetr. 11(4), 959-975.
https://doi.org/10.1016/j.joi.2017.08.007.
Bamel, U.K., Pandey, R., Gupta, A. 2020 . Safety climate: Systematic literature network analysis of 38 years (1980-2018) of research. Accid. Anal. Prev. 135, 105387.
https://doi.org/10.1016/j.aap.2019.105387.
Bhupatiraju, L., Bethala, K., Wen Goh, K., Singh Dhaliwal, J., Ching Siang, T., Menon, S., Menon, B., Anchu, K.B., Yee Chan, S., Chiau Ming, L., Khan, A. 2023. Influence of Murraya koenigii extract on diabetes induced rat brain aging. J. Med. Life. 16(2), 307-316.
https://doi.org/10.25122/jml-2022-0151.
Chen, C. 2004. Searching for intellectual turning points: Progressive knowledge domain visualization. Proc. Natl. Acad. Sci. U.S.A. 101 Suppl(Suppl 1), 5303-5310.
https://doi.org/10.1073/pnas.0307513100.
Desai, S.N., Patel, D.K., Devkar, R.V, Patel, P.V, Ramachandran, A.V. 2012. Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study. Food Chem. Toxicol. 50(2), 310-314.
https://doi.org/10.1016/j.fct.2011.10.063.
Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., Lim, W.M. 2021. How to conduct a bibliometric analysis: An overview and guidelines. J. Bus. Res. 133.
https://doi.org/10.1016/j.jbusres.2021.04.070.
Eljabboury, Z., Bentaib, R., Dajic Stevanovic, Z., Ousaaid, D., Benjelloun, M., Ghadraoui, L. 2023. Ammi visnaga (L.) Lam.: An overview of phytochemistry and biological functionalities. Trends Phytochem. Res. 7, 141-155.
https://doi.org/10.30495/tpr.2023.1987739.1347.
Falagas, M.E., Pitsouni, E.I., Malietzis, G.A., Pappas, G. 2008. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: Strengths and weaknesses. FASEB J. 22(2), 338-342.
https://doi.org/10.1096/fj.07-9492LSF.
Firdaus, S.B., Ghosh, D., Chattyopadhyay, A., Dutta, M., Paul, S., Jana, J., Basu, A., Bose, G., Lahiri, H., Banerjee, B., Pattari, S., Chatterjee, S., Jana, K., Bandyopadhyay, D. 2014. Protective effect of antioxidant rich aqueous curry leaf (Murraya koenigii) extract against gastro-toxic effects of piroxicam in male Wistar rats. Toxicol. Rep. 1, 987-1003.
https://doi.org/10.1016/j.toxrep.2014.06.007.
Franyoto, Y.D., Nurrochmad, A., Fakhrudin, N. 2024. Murraya koenigii L. Spreng.: An updated review of chemical composition, pharmacological effects, and toxicity studies. J. Appl. Pharm. Sci. 14(06), 1-17.
https://doi.org/10.7324/japs.2024.169254.
Gahlawat, D.K., Dheeraj, K., Jakhar, S., Dahiya, P. 2014. Murraya koenigii (L.) Spreng: An ethnobotanical, phytochemical and pharmacological review. J. Pharmacogn. Phytochem. 3, 109-119.
Gupta, S., Gerge, M., Singhal, M., Sharma, G.N., Garg, V. 2010. Leaves extract of Murraya koenigii Linn for anti- inflammatory and analgesic activity in animal models. J. Adv. Pharm. Technol. Res. 1(1), 68-77.
Gupta, S., Prakash, J. 2009. Studies on Indian green leafy vegetables for their antioxidant activity. Plant. Foods Hum. Nutr. 64(1), 39-45.
https://doi.org/10.1007/s11130-008-0096-6.
Kadam, S.H., Dombe, S., Naikwadi, P., Patil, M. 2011. Cardiovascular effects of aqueous extract of Murraya koenigii on isolated perfused frog heart preparation. J. Pharm. Res. 4(2), 462-463.
Kesari, A.N., Kesari, S., Singh, S.K., Gupta, R.K., Watal, G. 2007. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J. Ethnopharmacol. 112(2), 305-311.
https://doi.org/10.1016/j.jep.2007.03.023.
Khurana, A., Sikha, M.S., Ramesh, K., Venkatesh, P., Godugu, C. 2019. Modulation of cerulein-induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii). Phytother. Res. 33(5), 1510-1525.
https://doi.org/10.1002/ptr.6344.
Lawal, H.A., Atiku, M.K., Khelpai, D.G., Wannang, N.N. 2008. Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats. Niger. J. Physiol. Sci. 23(1-2), 37-40.
https://doi.org/10.4314/njps.v23i1-2.54919.
Mahipal, P., Pawar, R.S. 2017. Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats. Asian Pac. J. Trop. Med. 10(8), 808-812.
https://doi.org/10.1016/j.apjtm.2017.08.005.
Mandal, C., Roy, S., Dutta, D., Satyavarapu, E.M., Yadav, P.K., Mandal, C., Kar, S. 2017. Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis. Sci. Rep. 7(1), 1-16.
https://doi.org/10.1038/s41598-017-03943-y.
Mandal, Nayak, A., Kar, M., Banerjee, S.K., Das, A., Upadhyay, S.N., Singh, R.K., Banerji, A., Banerji, J. 2010. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia 81(1), 72-74.
https://doi.org/10.1016/j.fitote.2009.08.016.
Mohammadhosseini, M., Jeszka-Skowron, M. 2023. A systematic review on the ethnobotany, essential oils, bioactive compounds, and biological activities of Tanacetum species. Trends Phytochem. Res. 7(1), 1-29.
https://doi.org/10.30495/tpr.2023.700612.
Mohammadhosseini, M., Venditti, A., Flamini, G., Sarker, S., Kalaee, M. 2022. The genus Micromeria Benth.: An overview on ethnobotany, chemotaxonomy and phytochemistry. Trends Phytochem. Res. 6(3), 155-186.
https://doi.org/10.30495/tpr.2022.694114.
Mondal, P., Natesh, J., Penta, D., Meeran, S.M. 2022. Extract of Murraya koenigii selectively causes genomic instability by altering redox-status via targeting PI3K/AKT/Nrf2/caspase-3 signaling pathway in human non-small cell lung cancer. Phytomedicine 104, 154272.
https://doi.org/10.1016/j.phymed.2022.154272.
Mongeon, P., Paul-Hus, A. 2016. The journal coverage of Web of Science and Scopus: A comparative analysis. Scientometrics 106(1), 213-228.
https://doi.org/10.1007/s11192-015-1765-5.
Nagappan, T., Segaran, T.C., Wahid, M.E.A., Ramasamy, P., Vairappan, C.S. 2012. Efficacy of carbazole alkaloids, essential oil and extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules 17(12), 14449-14463.
https://doi.org/10.3390/molecules171214449.
Paul, S., Bandyopadhyay, T.K., Bhattacharyya, A. 2011. Immunomodulatory effect of leaf extract of Murraya koenigii in diabetic mice. Immunopharmacol. Immunotoxicol. 33(4), 691-699.
https://doi.org/10.3109/08923973.2011.561354.
Phatak, R.S., Khanwelkar, C.C., Matule, S.M., Hendre, A.S., Datkhile, K.D., 2021. Antioxidant activity of Murraya koenigii leaves methanolic and aqueous extracts on oxidative stress in high fat-fructose fed rats. Pravara Med. Rev. 13(3), 13-20.
https://doi.org/10.36848/PMR/2020/44100.51005.
Pokala, N., Sayeli, V.T.J. 2019. Evaluation of antipyretic activity of alcoholic extract of Murraya koenigii leaves in rabbits. Int. J. Basic Clin. Pharmacol. 8(7), 1577.
https://doi.org/10.18203/2319-2003.ijbcp20192653.
Rajendran, M.P., Pallaiyan, B.B., Selvaraj, N. 2014. Chemical composition, antibacterial and antioxidant profile of essential oil from Murraya koenigii (L.) leaves. Avicenna J. Phytomed. 4(3), 200-214.
Shah, A.S., Wakade, A.S., Juvekar, A.R. 2008. Immunomodulatory activity of methanolic extract of Murraya koenigii (L) Spreng. leaves. Indian J. Exp. Biol. 46(7), 505-509.
Sharif, N., Jabeen, H. 2024. Natural sources for coumarins and their derivatives with relevance to health-promoting properties: A systematic review. Trends Phytochem. Res. 8(3), 1-16.
https://doi.org/10.71596/tpr.2024.1103148.
Singh, D., Mittal, N., Siddiqui, M.H. 2023. A review on pharmacological potentials of phenolic diterpenes carnosic acid and carnosol obtained from Rosmarinus officinalis L. and modern extraction methods implicated in their recovery. Trends Phytochem. Res. 7(3), 156-169.
https://doi.org/10.30495/tpr.2023.1990761.1365.
Singh, S. 2014. Curry leaves (Murraya koenigii Linn. Sprengal)- A mircale plant. Indian J. Sci. Res. 4, 46-52.
Singh, S., Ahuja, A., Murti, Y., Khaliq, A. 2023. Phyto-pharmacological review on Murraya koenigii (L.) Spreng: As an Indigenous plant of India with high medicinal potential. Chem. Biodivers. 20(7), e202300483.
https://doi.org/10.1002/cbdv.202300483.
Tembhurne, S.V, Sakarkar, D.M. 2012. Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats. Asian Pac. J. Trop. Dis. 2, S166-S168.
https://doi.org/10.1016/S2222-1808(12)60145-5.
Thi Nguyen, T.T., The Diep, T., Hoang, V., Mai Vo, T.H., Duus, F., Ngoc Le, T. 2012. Investigation of curry leaf essential oils of Murraya koenigii Spreng. growing in the south of Vietnam. J. Essent. Oil Bear. Plants. 15(6), 1021-1029.
https://doi.org/10.1080/0972060X.2012.10662607.
Tripathi, Y., Anjum, N., Rana, A. 2018. Chemical composition and in vitro antifungal and antioxidant activities of essential oil from Murraya koenigii (L.) Spreng. Leaves. Asian J. Biomed. Pharm. Sci. 8(65), 6-13.
https://doi.org/10.4066/2249-622x.65.18-729.
Xie, Chang, W.T., Wang, C.Z., Mehendale, S.R., Li, J., Ambihaipahar, R., Ambihaipahar, U., Fong, H.H., Yuan, C.S. 2006. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am. J. Chin. Med. 34(02), 279-284.
https://doi.org/10.1142/S0192415X06003825.
Xie, H., Zhang, Y., Wu, Z., Lv, T. 2020. A bibliometric analysis on land degradation: Current status, development, and future directions. Land 9(1), 28.
https://doi.org/10.3390/land9010028.
Yankuzo, H., Ahmed, Q.U., Santosa, R.I., Akter, S.F.U., Talib, N.A., 2011. Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo. J. Ethnopharmacol. 135(1), 88-94.
https://doi.org/10.1016/j.jep.2011.02.020.