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        1 - The effect of eight weeks aerobic exercise on troponin T and metallothionein levels of cardiac tissue in healthy male rats
        Saeedeh Shadmehri Maryam Shabani Farhad Daryanoosh Mohammad Sherafati Moghadam
        Introduction: Cardiac Troponin T (cTnT) is currently considered as an ideal biomarker for the diagnosis of cardiac injury and Metallothionein has a protective effect against oxidative species damage. The aim of the present study is to investigate the effect of 8 weeks o More
        Introduction: Cardiac Troponin T (cTnT) is currently considered as an ideal biomarker for the diagnosis of cardiac injury and Metallothionein has a protective effect against oxidative species damage. The aim of the present study is to investigate the effect of 8 weeks of aerobic activity on Troponin T levels and Metallothionein of cardiac tissue in healthy male rats. Material & Methods: In this study, 20 Wistar male rats, aged 2 months with the weighted average of 180 ± 20 g, were selected and randomly divided into 2 groups: aerobic exercise (10) and control (10). The exercise group performed physical exercise 5 days a week according to the training program for 8 weeks. During this period, the control group did not exercise at all. After 8 weeks of training, independent t- test was used to analyze the data. Results: The results demonstrated there was no significant difference between the average Troponin T (P=0.77) in the exercise and control groups. No significant difference was also observed between Metallothionein in the training and control groups (P=0.15). Conclusions: It was revealed that the aerobic program used in the present study did not lead to increased cTnT which is indicative of cardiac injury. However, it increased Metallothionein levels (though insignificant) that can be helpful in preventing cardiac injury. Manuscript profile
      • Open Access Article

        2 - The effect of eight weeks high intensity interval training (HIIT) and continuous training on apelin levels of cardiac tissue in healthy male rats
        Saeedeh Shadmehri Maryam Shabani Farhad Daryanoosh Mohammad Sherafati Moghadam Neda Aghaei
        Introduction:Pathway apelin/APJ is one of the positive powerful inotropic substances which is an important regulator of cardiovascular operation and a significant factor in cardiovascular tissue. The aim of the present study is to investigate the effect of eight weeks h More
        Introduction:Pathway apelin/APJ is one of the positive powerful inotropic substances which is an important regulator of cardiovascular operation and a significant factor in cardiovascular tissue. The aim of the present study is to investigate the effect of eight weeks high intensity interval training (HIIT) and continuous Training on apelin levels of cardiac tissue in healthy male rats. Material & Methods: In this research, 30 Wistar 2-month male rats were chosen with average weight 180 ± 20 gr and randomly divided into 3 groups: continuous training (n=10), HIIT (n=10) or control group (n=10). Continuous training and HIIT groups have been engaged in exercising according training program in five days a week for 8 weeks. For the comparison among the groups, one-way analysis of variance (ANOVA) was performed. Results: No significant differences were observed in apelin levels between continuous training, HIIT and control group (P=0.29). Conclusion: According the results of this study, both exercises increased the apelin levels in heart; however this increase was not significant. It seems that the response of this hormone is different in organs so that it has more limitation in heart tissue than other organs. Therefore, it has been assumed that making noticeable changes in apelin levels of heart required much more time. Manuscript profile