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      • Open Access Article

        1 - Association among lifestyle status and dyslipidemia in Yasuj
        Masoud Yari Mehrzad Moghadasi Seyed Ali Hosseini Rahim Shirazi-nezhad
        Introduction: Dyslipidemia is caused by genetic and environmental factors that lead to problems with enzyme deficiencies, apolipoproteins, or lipoprotein particles. There are a number of factors that contribute to dyslipidemia; however these factors are not well known. More
        Introduction: Dyslipidemia is caused by genetic and environmental factors that lead to problems with enzyme deficiencies, apolipoproteins, or lipoprotein particles. There are a number of factors that contribute to dyslipidemia; however these factors are not well known. Thus the aim of this study was to determine the association among lifestyle status and dyslipidemia. Material & Methods: One hundred eighty three male (n=102; mean ± SD: 34.9 ± 11.8 years old) and female (n=81; mean ± SD: 32.4 ± 11.2 years old) participated in this study. Each subject’s lifestyle status was assessed by a self-administered questionnaire based on Breslow’s lifestyle index and a composite dietary behavior score obtained from self-reported responses to a 24-item food-frequency. Results: The results demonstrated a positive relationship between age and BMI with dyslipidemia (P<0.05). On the other hand, the results showed that there is a positive relationship between less healthy foods with total cholesterol, triglyceride and LDL-c and a positive relationship between healthy foods and HDL-c levels. General linear regression demonstrated that fast food consumption was independently associated with blood lipid profile in male and female. Conclusions: In conclusion, unhealthy lifestyle, especially having bad food consumption pattern may cause dyslipidemia. Manuscript profile
      • Open Access Article

        2 - Effect of aerobic training intensity on irisin in streptozotocin-induced diabetic rats
        Sahar Heidari Mehrzad Moghadasi
        Aim: Irisin is a recently identified exercise-induced hormone that increases energy expenditure. The effect of chronic aerobic training intensity on irisin concentration is not well known. Thus, we examine the effect of aerobic training intensity on irisin in streptozot More
        Aim: Irisin is a recently identified exercise-induced hormone that increases energy expenditure. The effect of chronic aerobic training intensity on irisin concentration is not well known. Thus, we examine the effect of aerobic training intensity on irisin in streptozotocin (STZ) -induced diabetic Wistar rats. Material & Methods: Diabetes was induced by intraperitoneal injection of STZ. Animals were randomly divided into four groups (n=8 in each group): control group (CON), diabetes group (D), diabetes and moderate-intensity exercise group (D + ME; running speed was set at 10-17 m.min-1), and diabetes and high-intensity exercise group (D + HE; running speed was set at 17-28 m.min-1). The rats in the exercise groups were made to run on the treadmill for 30 min per one day, 3 times a week, during 8 weeks. Results: The results indicated that serum irisin concentration was higher in the D + HE group than CON, D and D + ME groups (P<0.05) and no significant differences were observed between CON group and D + ME group. Conclusions: Our findings suggest that that exercise intensity has an effect on exercise-induced irisin responses. Manuscript profile
      • Open Access Article

        3 - Effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise
        Nooshin Khajeian Mehrzad Moghadasi
        Introduction: Galectin-3 (gal-3) is a member of the lectin family that is associate with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. Although gal-3 increases after high intensity exercise, More
        Introduction: Galectin-3 (gal-3) is a member of the lectin family that is associate with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. Although gal-3 increases after high intensity exercise, regular training may attenuate these conditions. The aim of present study was to investigate the effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise. Material & Methods: Elevenhealthy young men (aged: 20.8 ± 1.8 years; ± SD) volunteered to participate in this study. All the subjects were performed Repeated High-Intensity Endurance Test (RHIET) as a strenuous aerobic exercise. Thereafter, the subjects were performed endurance training 3 days a week for 8 weeks at an intensity corresponding to 60-75% individual heart rate reserve (HRR) for 30-45 min. After the 8 weeks intervention, the RHIET was performed a gain. Blood samples were taken at baseline (1st step), immediately after the RHIET (2nd step), 48h after 8 weeks intervention (3rd step) and immediately after the second RHIET (4th step). Results: The results showed that gal-3 level was increased after the first strenuous aerobic exercise (P<0.05). After 8 weeks exercise training, gal-3 was decreased compared to 2nd step of blood sampling (P<0.05) and no significant change was observed in gal-3 in this step compare to the baseline. The results indicated that gal-3 level was lower after the second strenuous aerobic exercise than compare to the after the first strenuous aerobic exercise (P<0.05). Conclusions: The results suggest regular endurance training with specific intensity and duration utilized in this study, attenuate gal-3 changes after single session of strenuous aerobic exercise. Manuscript profile
      • Open Access Article

        4 - Effect of 8 weeks regular resistance training on attenuation of sdLDL changes after single session of heavy resistance exercise
        Hamid Reza Nayeri khoob Mehrzad Moghadasi
        Introduction: Although heavy exercise can independently increase free radical production that may enhance the susceptibility of LDL to oxidation and create more atherogenic LDL particles such as sdLDL, regular training may attenuate these atherogenic conditions. The aim More
        Introduction: Although heavy exercise can independently increase free radical production that may enhance the susceptibility of LDL to oxidation and create more atherogenic LDL particles such as sdLDL, regular training may attenuate these atherogenic conditions. The aim of present study was to investigate the effect of 8 weeks regular resistance training on attenuation of sdLDL changes after single session of heavy resistance exercise. Material & Methods: Elevenhealthy young men (aged: 26.6 ± 1.5 years; ± SD) volunteered to participate in this study. One reparation maximum (1-RM) was measured and the subjects were performed a heavy resistance exercise trial consisted of eight exercises (chest press, triceps extension, latissimus pull down, shoulder press, arm curls, leg extension, leg curls, and curl-up) of 8 repetitions with 3 sets at 80% of 1RM. Thereafter, the subjects were performed the same 8 stations resistance training in 3 sets with 6-12 maximal repetitions. This training was performed 3 days a week with 65-80% of 1-RM, for 8 weeks. After the 8 weeks intervention, the heavy resistance exercise trial was performed a gain. Blood samples were taken at baseline (1st step), immediately after the first heavy resistance exercise trial (2nd step), 48h after 8 weeks intervention (3rd step) and immediately after the second heavy resistance exercise trial (4th step). Results: The results showed that sdLDL level was increased after the first heavy resistance exercise trial (P<0.05). After 8 weeks exercise training, sdLDL was decreased compared to 2nd step of blood sampling (P<0.05) and no significant change was observed in sdLDL in this step compare to the baseline. The results indicated that sdLDL level had not significant change after the second heavy resistance exercise trial compare to the 2nd step of blood sampling. Conclusions: The results suggest regular resistance training with specific intensity and duration utilized in this study, attenuate sdLDL changes after single session of heavy resistance exercise. Manuscript profile
      • Open Access Article

        5 - Regular aerobic training improves insulin resistance but not pancreatic β-cells function in female patients with type 2 diabetes
        Mohsen Omidi Mehrzad Moghadasi
        Aim: Pancreatic β-cells function and insulin sensitivity resistance were impaired in type 2 diabetes. Exercise training may improves these impairs, however, this is not well known. The aim of present study was to examine the effect of 8 weeks aerobic training on pa More
        Aim: Pancreatic β-cells function and insulin sensitivity resistance were impaired in type 2 diabetes. Exercise training may improves these impairs, however, this is not well known. The aim of present study was to examine the effect of 8 weeks aerobic training on pancreatic β-cells function and insulin resistance in female patients with type 2 diabetes. Material & Methods: Twenty middle-aged women (age, 40 -50 years) with type 2 diabetes participated as the subject. The subjects were randomly assign to control group (n=10) or the training group (n=10). The subjects in the training group performed 30 to 45 min aerobic training on the treadmill with 60-75% of their maximum heart rate, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Results: The results indicated that fasting blood sugar, fasting insulin and insulin resistance index decrease in the training group compare to the control group (P<0.05); however, pancreatic β-cells function has no significant change after the intervention. Conclusion: In summary, it seems that aerobic training utilized in this study improves glucose entry into cells but it had not effective on pancreatic β-cells function. Manuscript profile