Hollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery

Subject Areas : Journal of Nanoanalysis

Zohreh Jomeh Farsangi ¹ , Seyed Mehdi Rezayat ² , Ali Beitollahi ³ , Saeed Sarkar ⁴ , Mahmoudreza Jaafari ⁵ , Amir Amani ⁶

1 - School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran
2 - School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran
3 - Center of Excellence for advanced Materials and processing, Iran University of Science and Technology, Narmak, Tehran, Iran
4 - School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran
5 - Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
6 - School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran

Received: 2017-05-31 Accepted : 2017-05-31 Published : 2016-12-01

Keywords: Cisplatin, Drug delivery, Hollow mesoporous silica, Sustained release,

Abstract :

Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make them promising platforms for efficient drug delivery systems. In this study, hollow mesoporous silica nanoparticles (HMSNs) were successfully synthesized by a hard-templating method. Further, the synthesized HMSNs were studied by characterizing their morphology, nanostructure, specific surface area, particle size distribution and chemical composition using FESEM, HRTEM, N2-Sorption and FTIR techniques, respectively. The high specific surface area (1201 m2g-1) of the prepared HMSNs resulted in relatively high loading capacity of cisplatin (35 wt.%). Furthermore, release test performed at pH value of 7.4 showed a sustained release pattern. The cytotoxicity of the formulated drug was also examined in c26 colon carcinoma cell lines by MTT assay. The drug loaded HMSNs showed a lower toxicity than free drug due to the sustained drug release.