Fabrication, Characterization and Osteoblast Response of Cobalt-Based Alloy/Nano Bioactive Glass Composites

Subject Areas : Finite Element Modeling

Mohammad Reza Bafandeh ¹ (Department of Materials Science and Engineering, Faculty of Engineering, University of Kashan, Kashan, I.R. Iran)
Raziyeh Gharahkhani ² (Department of Materials Engineering, Isfahan University of Technology (IUT), Isfahan 84156-83111, Iran)
Mohammad Hossein Fathi ³ (Department of Materials Engineering, Isfahan University of Technology (IUT), Isfahan 84156-83111, Iran)

Received: 2016-06-09 Accepted : 2016-07-17 Published : 2016-09-01

Keywords: Sintering, Biomaterials, Nano bioactive glass Response Surface, Osteoblast response,

Abstract :

IIn this work, cobalt-based alloy/ nano bioactive glass (NBG) composites with 10, 15 and 20 wt% NBG were prepared and their bioactivity after immersion in simulated body fluid (SBF) for 1 to 4 weeks was studied. The scanning electron microscopy images of two- step sintered composites revealed a relatively dense microstructure the density of which decreased with the increase in the NBG amount. Microstructural analysis as well as energy dispersive X-ray analysis (EDX) revealed that after 1 week of immersion in SBF, a small amount of calcium phosphate phases precipitates on the surface of the composite samples. After 2 weeks of immersion, a considerable amount of cauliflower-like shaped precipitations was observed on the surface of composites. The observed peaks in the Fourier transform infrared (FTIR) spectroscopy of the composite samples in SBF immersed for 4 weeks were assigned to hydroxyapatite. Therefore, a hydroxyapatite layer has been possibly formed on the surface of the composite samples during immersion in SBF. Cell culture results indicate that unlike the Co-based alloy, the Co-based/NBG composites are bioactive and bone cells could be vivid and grow on their surfaces, promising their possibility for implant applications.

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