Evaluation of Kelussia odoratissima Mozaff. extract on serum biochemical parameters and hepatica enzymes in the Persian Shepherd dogs
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)اردلان معینی 1 , سام ترکان 2 , فاطمه ملک پور 3
1 - دانش آموخته دانشکده دامپزشکی دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
2 - گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
3 - گروه گیاهان داروئی،مرکز پژوهش های گیاهان دارویی و دام پزشکی سنتی واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران
Keywords: Extract, Dog, Kelussia Odoratissima Mozaff, Lipid profiles, Hepatica enzyme,
Abstract :
Background & Aim:Nowadays, attention has increasingly been directed toward the treatment of animal’s disease using medicinal herbs. This research was conducted to evaluate the impact of Kelussia odoratissima Mozaff extract on dog serum biochemical parameters and hepatica enzymes over time. Experimental: 32 adult dogs were randomly assigned to four groups. The first (control) group did not receive any pharmaceutical compound. The second group received 150 mg/kg of hydro-alcoholic extract of k.odoratissima. The third and the forth groups received 300 and 450 mg/kg of the extract, respectively. Finally, the blood samples were collected on days 0, 5, 10, and 15 for serum biochemical parameters analysis including the level of blood sugar, cholesterol, triglyceride, LDL and HDL, alanine aminotransferase, aspartate aminotransferases, and alkaline phosphatase. Results: Comparing to the control group, the levels of fast blood sugar, low density lipoprotein, high density lipoprotein, trigliceride, cholesterol, Alanin aminotransferase and aspartate aminotransferase in treated groups were significantly different over time and at various doses of the extract (P<0.05). However, the level of Alkaline-phosphatase (ALP) factor did not change throughout this study (P>0.05). Recommended applications/industries: Considering the results of this study, anti-diabetic, anti-atherosclerotic and antioxidant effects of Kelussia odoratissima can be concluded. Then, the possibility of employing K. odoratissima extract in drugs for the treatment of mentioned diseases can be suggested.
Broadhurst, C.L., Polansky, M.M. and Anderson, R.A. 2000. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. Journal of agricultural and food chemistry, 48(3): 849-852.
Hosseini, A., Bakhtiari, E., Rad, A.K., Shahraki, S., Mousavi, S.H., Havakhah, S. and Amiri, M.S. 2017. The evaluation and comparing of cytotoxic effects of Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima and Artemisia kopetdaghensis extracts on ACHN cell line. Iranian journal of pharmaceutical research, 16(3): 1104-1112.
Jurikova, T., Sochor, J., Rop, O., Mlcek, J., Balla, S., Szekeres, L., Adam, V. and Kizek, R. 2012. Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida Bunge) fruits. Molecules, 17(12): 14490-14509.
Kafeshani, M., Mirhosseini, M., Momeni, A., Rabiei, R. and Rafieian-Kopaei, M. 2017. Impact of Kelussia odoratissima Mozaffarian lipid profile and fasting blood sugar in hyperlipidemia patients. Journal of nephropharmacology, 6(1): 9-12.
Kim, J.D., Kang, S.M., Park, M.Y., Jung, T.Y., Choi, H.Y. and Ku, S.K. 2007. Ameliorative anti-diabetic activity of dangnyosoko, a Chinese herbal medicine, in diabetic rats. Bioscience, biotechnology, and biochemistry, 71(6): 1527-1534.
Kooti, W., Ghasemiboroon, M., Asadi-Samani, M., Ahangarpoor, A., Noori Ahmad Abadi, M., Afrisham, R. and Dashti, N. 2014. The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet. Advances in Environmental Biology, 8(9 SPEC): 325-330.
Mansi, K., Abushoffa, A.M., Disi, A. and Aburjai, T. 2009. Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats. Pharmacognosy magazine, 5(20): 301-305.
Moghadam, M.H., Imenshahidi, M. and Mohajeri, S.A. 2013. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. Journal of medicinal food, 16(6): 558-563.
Momtazi, A.A., Askari-Khorasgani, O., Abdollahi, E., Sadeghi-Aliabadi, H., Mortazaeinezhad, F. and Sahebkar, A. 2017. Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia odoratissima Mozaff. Journal of acupuncture and meridian studies, 10(3): 180-186.
Mosallanejad, B., Jalali, M.R., Avizeh, R. and Pourmohammad, N. 2018. Comparative evaluation of the effects of chitosan and atorvastatin on serum lipid profile changes in dogs. Journal of Veterinary Research, 73(1): 101-109.
Palsamy, P. and Subramanian, S. 2009. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin–nicotinamide-induced diabetic rats. Chemico-biological interactions, 179(2-3): 356-362.
Pirbalouti, A.G. 2009. Medicinal plants used in Chaharmahal and Bakhtyari districts of Iran. Herba Polonica, 55(2): 69-77.
Rabbani, M., Sajjadi, S.E. and Sadeghi, M. 2011. Chemical composition of the essential oil from Kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice. Clinics, 66(5): 843-848.
Rafieian-Kopaei, M., Shahrani, M., Pilehvarian, A.A., Kheyri, S., Rabiei, R., Momeni, A., Asgari, A. and Parvin, N. 2009. Effect of Kelussia odoratissima Mozaffarian (KOM) on hyperlipidemia: a clinical trial study. Shahrekord University of Medical Sciences Journal, 10(41).
Renault, S., De Lucca, A.J., Boue, S., Bland, J.M., Vigo, C.B. and Selitrennikoff, C.P. 2003. CAY-I, a novel antifungal compound from Cayenne pepper. Medical mycology, 41(1): 75-82.
Shahrani, M., Pilehvarian, A.A., Kheyri, S., Asgari, A., Farokhi, E., Parvin, N. and Rafieian-Kopaei, M. 2009. Effects of Kelussia odoratissima Mozaffarian (KOM) extract on blood lipid in Balb/c mice. Journal of Shahrekord Uuniversity of Medical Sciences, 10(4): 50-56.
Shahreza, F.D. 2017. Kelussia odoratissima Mozaffarian and dyslipidemia. Journal of nephropharmacology, 6(1): 13-14.
Shakerian, A., Sohrabi, M.J. and Ghasemi Pirbalouti, A. 2012. Effect of Bakhtiari celery (Kelussia odoratissma Mozaff) on sensory properties and shelf life of set yogurt. Journal of Herbal Drugs (An International Journal on Medicinal Herbs), 3(1): 41-48.
Soleymanifard, S., Bahreyni Toossi, M.T., Mohebbi, S., Sazgarnia, A. and Mohajeri, S.A. 2014. An investigation of the effects of raw Garlicon radiation-induced bystander effects in MCF7 cells. Iranian Journal of Medical Physics, 11(4): 350-357.
Talebanpour, B.Z., Aghababa, H. and Shojaei, F.M. 2015. Protective effects of hydro-alcoholic extract of Apium graveolenson carbon tetrachloride induced hepatotoxicity in Sprague-Dawley male rats. 5(1): 102-110.
Tashakori-Sabzevar, F., Ramezani, M., Hosseinzadeh, H., Parizadeh, S.M.R., Movassaghi, A.R., Ghorbani, A. and Mohajeri, S.A. 2016. Protective and hypoglycemic effects of celery seed on streptozotocin-induced diabetic rats: experimental and histopathological evaluation. Acta diabetologica, 53(4): 609-619.
Vahid Dastjerdi, A., Jafarian Dehkordi, M. and Torkan, S. 2017. Possible allergic effects and haematological changes induced by oral intake of sumac (Rhus coriaria L.) compared to levamisole in dogs. Journal of Herbal Drugs (An International Journal on Medicinal Herbs), 8(3): 149-157.
Yusni, Y., Zufry, H., Meutia, F. and Sucipto, K.W. 2018. The effects of celery leaf (Apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics. Saudi medical journal, 39(2): 154.
Yahooi, S.M., Sadoughi, S.D. and Rahbarian, R. 2017. The Effect of Aqueous Extract of Launaea acanthodes on Liver Enzymes and Histopathology in Male Type 1 Diabetic Rats. Journal of Rafsanjan University of Medical Sciences, 15(9): 861-874.
Xenoulis, P.G. and Steiner, J.M. 2010. Lipid metabolism and hyperlipidemia in dogs. The Veterinary Journal, 183(1): 12-21.