Effect of Protein Corona Formation on Photonic Response of Upconverting Nanoparticles

Subject Areas : Nano Biophotonics

Nahid Ghazyani ¹ , Mohammad Hossien Majles Ara ²

1 - Faculty of Physics, Kharazmi University, Tehran, Iran
2 - 1. Department of physics, Kharazmi University, Tehran, Iran. 2. Applied Sciences Research Center, Kharazmi University, Karaj, Iran.

Received: 2023-05-06 Accepted : 2023-09-17 Published : 2023-09-22

Keywords: Nonlinear photoresponse, Upconversion Nanoparticles, Protein Corona, Corona Formation, human blood plasma, near infrared,

Abstract :

NaYF4:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at 545 nm and 660 nm under an excitation of 980 nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and characterized and phase transition from organic to aquas by synthesis a SiO2 shell have done successfully. The results show that the nonlinearity response of NaYF4: Yb, Er@SiO2 is same as NaYF4: Yb, Er and SiO2 has no effect on emission peaks it means that these nanoparticles are suitable for biomedical applications. Since it is necessary to know the photoluminescent behavior of UCNPs@SiO2 particles, thereby the fluorescence properties of up-conversion nanoparticles with SiO2 shell have been investigated in PBS, normal and cancerous human blood plasma. The results indicate that UCNP@SiO2 can be applicable in biological medias for therapy and diagnostic.

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