The effect of Fisetin on the colorectal cancer: a review

Subject Areas :

Navideh Khodadadi ¹ , Behnood Abbasi ²

1 - Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 - Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch. Islamic Azad University, Tehran, Iran.

Received: 2020-02-07 Accepted : 2020-05-09 Published : 2020-06-15

Keywords: inflammation, Colorectal Neoplasms, Antioxidants, Fisetin, Apoptosis,

Abstract :

Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In the present study, we summarized the potential mechanisms of the effect of Fiestin on CRC. Electronic literature searches were conducted on Medline, Web of Science, and Google Scholar until March 2020. Our search was supplemented with the search of publisher databases like Elsevier and Springer. The search was conducted with “Fiestin” in combination with the following keywords: Colorectal Neoplasms, Colon, Rectum, Apoptosis, Inflammation, and “Precancerous Lesions” among humans, animal, and in-vitro studies. 14 articles during 2005 and 2018 assessed the effect of Fiestin on CRC. One was RCT, 3 of them were animal studies and 10 papers were performed on cell culture. Our Findings suggested that Fiestin may have positive effects on cancer cells due to its anti-inflammatory, apoptotic, anti-oxidative, and cell cycle modifying properties. According to the literature, it seems that Fiestin induces cell cycle arrest and suppresses cellular growth by modulating through some signaling pathways like inhibition of CDKs and Fiestin decreases protein levels of cell division cycles like CDC 2 and CDC25C. Fiestin may also induce cell apoptosis cascades such as activation of caspase 3, 7, and cleavage of procaspase 3 and inhibition of caspase 8. Fiestin also may have anti-inflammatory effects by inhibiting PGE2 production and expression of COX2. Additionally, it may have some anti-oxidant effects by reducing some tumor markers and enhancement levels of some anti-oxidants agents.

References:

1. Nahas ARM, Sarriff A, Othman S. Diet and colorectal cancer: knowledge assessment among Malaysian university students. International Journal of Research in Pharmaceutical Sciences. 2013;4(2):194-7.


2. Schnekenburger M, Diederich M. Epigenetics offer new horizons for colorectal cancer prevention. Current Colorectal Cancer Reports. 2012;8(1):66-81.


3. Mirzaeipour A, Salehifar E, Janbabai G, Kouchaki B, Borhani S, Rashidi M. Demographic and Clinical Characteristics of Patients with Colorectal Cancer. Journal of Mazandaran University of Medical Sciences. 2015;24(121):66-73.


4. Suh Y, Afaq F, Johnson JJ, Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis. 2009;30(2):300-7.


5. Farsad-Naeimi A, Alizadeh M, Esfahani A, Darvish Aminabad E. Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food & Function. 2018;9(4):2025-31.


6. Jeng LB, Kumar Velmurugan B, Chen MC, Hsu HH, Ho TJ, Day CH, et al. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo. Journal of Cellular Physiology. 2018;233(9):7134-42.


7. Leu JD, Wang BS, Chiu SJ, Chang CY, Chen CC, Chen FD, et al. Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models. Oncology Letters. 2016;12(6):4975-82.


8. Li X, Pu J, Jiang S, Su J, Kong L, Mao B, et al. Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells. PLoS One. 2013;8(7):e68525-e.


9. Saw CLL, Kong A-NT. Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer. Expert Opinion on Therapeutic Targets. 2011;15(3):281-95.


10. Hall MJ, Morris AM, Sun W. Precision Medicine Versus Population Medicine in Colon Cancer: From Prospects of Prevention, Adjuvant Chemotherapy, and Surveillance. American Society of Clinical Oncology Educational Book. 2018(38):220-30.


11. Lu X, Jung J, Cho HJ, Lim DY, Lee HS, Chun HS, et al. Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. The Journal of Nutrition. 2005;135(12):2884-90.


12. Wu MS, Lien GS, Shen SC, Yang LY, Chen YC. N-acetyl-L-cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells. Molecular Carcinogenesis. 2014;53 Suppl 1:E119-29.


13. Syed DN, Adhami VM, Khan MI, Mukhtar H. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anti-Cancer Agents in Medicinal Chemistry. 2013;13(7):995-1001.


14. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxidants and Redox Signaling. 2013;19(2):151-62.


15. Touil YS, Seguin J, Scherman D, Chabot GG. Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. Cancer Chemotherapy and Pharmacology. 2011;68(2):445-55.


16. Lim DY, Park JHY. Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2009;296(5):G1060-G8.


17. Kunchari Kalaimathi S, Sudhandiran G. Fisetin ameolirates the azoxymethane and dextran sodium sulfate induced colitis associated colorectal cancer. International Journal of Pharmaceutical and Clinical Research. 2016;8:551-60.


18. Kim DH, Lee JT, Lee IK, Ha JH. Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells. Biological & pharmaceutical Bulletin. 2008;31(2):255-9.


19. Youns M, Abdel Halim Hegazy W. The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways. PLoS One. 2017;12(1):e0169335-e.


20. Wu MS, Lien GS, Shen SC, Yang LY, Chen YC. HSP90 inhibitors, geldanamycin and radicicol, enhance fisetin-induced cytotoxicity via induction of apoptosis in human colonic cancer cells. Evidence-Based Complementary and Alternative Medicine. 2013;2013:987612-.


21. Yu SH, Yang PM, Peng C-W, Yu YC, Chiu SJ. Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis. Cancer Letters. 2011;300(1):96-104.


22. Chen WS, Lee YJ, Yu YC, Hsaio CH, Yen JH, Yu SH, et al. Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin. International Journal of Radiation Oncology, Biology, Physics. 2010;77(5):1527-35.


23. Lee SW, Lee JT, Lee MG, Lee HW, Ahn SJ, Lee YJ, et al. In vitro antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells. Journal of Natural Medicines. 2009;63(2):124-9.


24. Hashemi M, Ghavami S. Methods of Studying the Apoptosis. Journal of Rafsanjan University of Medical Sciences. 2008;7(1):71-8.