List of Articles احمد عبدی

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  1 - Synergistic Effects of Aerobic Training and Capsaicin on Visceral Adipose Tissue SIRT1 Gene Expression and Insulin Resistance in Rat Fed a High-Fat Diet.
  Elham Heydarzadeh Ahmad Abdi Masoomeh Alsadat Mirshafaei Rostam Abdi
  10.30486/epp.2022.1966179.1001
  Background: Metabolic dysregulation may cause tissue damage in obesity-related diseases. The effects of SIRT1 on metabolism may provide a therapeutic target for treating obesity-related diseases. This study aimed to investigate the effects of aerobic training and Capsai More

  Background: Metabolic dysregulation may cause tissue damage in obesity-related diseases. The effects of SIRT1 on metabolism may provide a therapeutic target for treating obesity-related diseases. This study aimed to investigate the effects of aerobic training and Capsaicin (Cap) on visceral adipose tissue SIRT1 gene expression and insulin resistance in rats fed a high-fat diet (HFD).Methods: 40 male Wistar rats were fed a normal diet (ND, n = 8) or HFD (n = 32) for 8 weeks. After 8 weeks, all rats were divided into five groups: ND, HFD, high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), and high-fat diet-training-capsaicin (HFDTCap). Training groups performed a progressive aerobic running program (at 15-25 m/min, 30-60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day.Results: This study showed that SIRT1 expression decreased and HOMA-IR increased in the HFD group compared to the ND group. Also, the expression of SIRT1 in HFDT, HFDCap, and HFDTCap groups significantly increased compared to HFD. The expression of SIRT1 in HFDTCap also significantly increased compared to HFDT and HFDCap groups. There was a significant decrease in HOMA-IR levels in all experimental groups.Conclusion: Possibly, eight weeks of progressive training combined with capsaicin administration has an effect on the glucose homeostasis of HFD rats by increasing the expression of SIRT1 and decreasing HOMA-IR. Manuscript profile
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  2 - Protective Effect of aerobic exercise training along with hydroalcoholic cinnamon extract on inflammatory indicators and oxidative stress in rats fed a high-fructose drink
  Fatemeh Hosseini Rostam Abdi Fatemeh Noori Ghasem  Torabi Pelet Kale Ahmad Abdi
  Background: Inflammatory indicators and oxidative stress play an important role in insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on inflammatory indicators and oxidative stress in rats fed a high-fructo More

  Background: Inflammatory indicators and oxidative stress play an important role in insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on inflammatory indicators and oxidative stress in rats fed a high-fructose drink. Methods: Thirty-six Wistar male rats divided into groups: control (n=9), aerobic exercise (n=9), cinnamon extract (n=9), and aerobic exercise –cinnamon extract (n=9). Insulin-resistance status induced by %10 fructose solutions. Exercise groups subjected to a 5-day per week aerobic exercise program (with 75-80% VO2max) for 8 weeks. Extract groups subjected was Injected 200 mg/kgBW/day cinnamon extract. Data were analyzed using one-way ANOVA and statistical significance was set at p<0/05. Results: The results showed that aerobic training with or without extract caused to a significant decrease in serum TNF-α, IL-6 and CRP (p<0/05). Indeed, in all three experimental groups, SOD and GPX increased significantly compared to control (P<0.05). MDA levels also decreased significantly in experimental groups compared to control group (P<0.05). Conclusion: Results of this study indicated that aerobic exercise and cinnamon reduced inflammatory indicators and oxidative stress in rats fed a high-fructose drink. Also, cinnamon extract with aerobic exercise has a greater effect on these indicators. Manuscript profile