Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces

Subject Areas : meso/micro/nano fabrication

Alireza  Alaghemand ¹ (Electrical Engineering Department, Shahrood University of Technology, Shahrood, Iran)
Ali  Fattah ² (Electrical Engineering Department, Shahrood University of Technology, Shahrood, Iran)

Received: 2022-04-23 Accepted : 2022-08-07 Published : 2022-09-01

Keywords: Microfluidics, Cancer cells, Dielectrophoresis, COMSOL, separation,

Abstract :

A microchannel device was designed and utilized to separate Michigan Cancer Foundation-7 cells from white blood cells using both wall-induced lift and di-electrophoresis forces. Using COMSOL Multiphysics simulator, the label-free separation process is performed based on the radius size of the particles. The best performance of the structure is obtained with the efficiency of 100% and 99% for cancer and white blood cells separation processes, respectively. For the proposed microfluidic structure, in addition to the highest available efficiency and high separation speed of 12 um/s, the low DC voltage of 6 V is applied, which causes negligible damage to the blood cells.

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